There are plenty in the the list archive, one of which is to switch to a run
64-bit R on a 64-bit platform with lots of physical RAM.  Such hardware is
quite affordable these days (certainly cheaper than most commercial software
that you'd have to buy if you didn't have R).

Andy

From: r user
> 
> I am using R 2.2.1 in a Windowes XP environment.
> 
> I work with very large datasets, and occassionally run
> out of memory.
> 
> I have modified my boot.ini file to use the "/3gb
> switch".
> 
> I also run the following line after I launch R ( I am
> unsure if it is helpful).
> 
> "memory.limit(size = 4095)"
> 
> Please point me to useful references on how to better
> manage memory, or suggestother actions.
> 
> ______________________________________________
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> PLEASE do read the posting guide! 
> http://www.R-project.org/posting-guide.html
> 
>

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