I had a large SaddleSack that I tried. I found that its attachment to the bike a detriment for commuting. I had to put a bag inside the bag to get my stuff into the building where I have access to a shower. What I really like about the pannier and the Synapse are their ability to easily come inside with me. I also hated the idea of leaving my laptop in the bag if I had to run an errand on the way home.
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