Dear all,

Just to make sure this thread contains the relevant info:

The same problem also affects conda installs on Windows, at least with
python v2.7.
The solution is to downgrade your conda version to v4.3.25
I've confirmed that the current RDKit distributions work with v4.3.25 of
conda and the python 2.7 version it installs (2.7.13).


On Mon, Oct 2, 2017 at 3:38 PM, Greg Landrum <> wrote:

> Dear all,
> I've noticed a problem with anaconda python on the Mac. This may also be a
> problem on linux, but I haven't tested that yet.
> Due to some changes in the way the anaconda team is doing python builds,
> the most recent conda python builds seem to no longer work with the RDKit.
> The symptom is an error message like "Fatal Python error:
> PyThreadState_Get: no current thread" when you try to import the rdkit.
> I've observed this for the newest 3.5 (3.5.4-hf91e954_15) and 3.6
> (3.6.2-hd0bf7f1_15) builds. A workaround is to downgrade to 3.5.3 (conda
> install python=3.5.3) or 3.6.1 (conda install python=3.6.1).
> I haven't yet figured out how to handle this "correctly" - and based on
> some preliminary email conversation with Riccardo it looks non-trivial - so
> please be sure you're using the earlier python versions with the RDKit
> builds.
> Apologies for this,
> -greg
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