Hi, Long story short, I'm using rdChiral to extract reaction templates from Reaction SMILES.
I've found an issue with substructure matching when using a large molecule, a large pattern, having lots of chiral centers and the HasSubstructMatch & GetSubstructMatches have useChirality set to True, the process hangs. Here is a notebook showing the issue https://nbviewer.jupyter.org/gist/CKannas/d54bb5ab0fa3c964086c75f18250ddac Is there any workaround for this? Looking for a solution to stop the computation in a graceful manner. Thanks, Christos Christos Kannas Research Software Engineer (Cheminformatics) [image: View Christos Kannas's profile on LinkedIn] <http://cy.linkedin.com/in/christoskannas>
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