Dear relax users:
I have a couple of questions regarding the relax program.
First, the example scripts for model-free selection and optimization
described in the relax manual utilize 15N relaxation data recorded at
two or three fields. Does anyone have advice/experience in using relax
to fit T1, T2 and NOE data recorded at only one field, particularly to
models that include anisotropic global motion?
Idealy, I would like to follow a local t_m approach to model-free model
selection and optimization, as recently described [d'Auvergne and Gooley
(2008) J. Biomol. NMR 40, 107-119; /ibid./, 121-133], rather than a
"diffusion seeded" approach. With data at one field, this analysis would
be limted to models /tm0/ through /tm3,/ and /tm9/. Are there relax
scripts available for this type of an analysis with data at one field?
Also, again using data from only one field, could one readily discern
from the results of a local t_m analysis if isotropic diffusion models
are adequate? If adequate, this would allow fitting the data to models
/m0/ through /m5/, and /m9/.
A final question - have any facilites been added to relax (or planned)
for fitting methyl ^2 H relaxation data?
Thank you very much for your consideration. Any suggestions would be
greatly appreciated.
Keith Constantine
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