http://mail.python.org/pipermail/distutils-sig/2001-January/001807.html

I think your answer is in there

L

2008/12/19 James Yoo <james....@gmail.com>:
> yes, I have R in the path... the hang up is that the rpy2 binary installer
> expects to find python in the registry... hoping someone on this list might
> have had success installing rpy2 on windows (python not registered) with the
> binary installer
>
>
> On Fri, Dec 19, 2008 at 3:09 PM, Peter <rpy-l...@maubp.freeserve.co.uk>
> wrote:
>>
>> On Fri, Dec 19, 2008 at 8:53 PM, James Yoo <james....@gmail.com> wrote:
>> > I have a binary install of python2.5 and R-2.8.0, both in non-standard
>> > locations and not in the registry.  Is there a way to get the rpy2
>> > installer
>> > to see my python install without inspecting the registry?
>>
>> If you were compiling R from source, I would advise you make sure R is
>> on the path, or (assuming you have a recent rpy2) set the R_HOME
>> environment variable.  There have been a couple of threads on the
>> mailing list recently about this.
>>
>> For the setup installer, these are still worth trying, but I don't
>> know if they will work or not.
>>
>> Peter
>>
>>
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