One example is https://github.com/mwageringel/fgb_sage, which is a small wrapper for an external C binary and which uses sage_sample as a template. The relevant part is the setup.py file, which downloads the external files and makes them available for compiling the Cython code. It does not use pipx (which I do not know about), but is implemented in a somewhat ad-hoc fashion, so probably this is not the optimal way to achieve this but could be streamlined a bit.
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