Could it be that you need to update your Homebrew (?) python3 package?
What version do you have now?
E.g. on a box where the latest Sage builds I have

% brew info python3

python@3.9: stable 3.9.1 (bottled)
Interpreted, interactive, object-oriented programming language
https://www.python.org/
/usr/local/Cellar/python@3.9/3.9.1_8 (4,057 files, 67.8MB) *
  Poured from bottle on 2021-02-06 at 10:13:24
From: https://github.com/Homebrew/homebrew-core/blob/HEAD/Formula/pyt...@3.9.rb


On Mon, Feb 8, 2021 at 1:53 PM Trevor Karn <trevor.k.k...@gmail.com> wrote:
>
> Ah I see, thanks for explaining.
>
> Here is my top-level config.log.
>
> Best Regards,
>
> Trevor Karn
>
>
> On Mon, Feb 8, 2021 at 7:09 AM Dima Pasechnik <dimp...@gmail.com> wrote:
>>
>>
>>
>> On Mon, 8 Feb 2021, 13:02 Trevor Karn, <trevor.k.k...@gmail.com> wrote:
>>>
>>> Thanks for sending that link. I am confused though, because it says a fix 
>>> was issued. Does that mean it should work now?
>>
>>
>> sorry, I was not clear. What I meant to say that it appears to be a 
>> well-known issue in the Python@macOS universe,
>> and lately all seems to be OK with Sage.
>>
>> To figure out exactly goes wrong in your case, we need to know where Python3 
>> used in Sage is coming from.
>> Please post the top-level config.log
>>
>>
>>>
>>> And yes, I am on the most recent develop branch
>>>
>>> On Mon, Feb 8, 2021 at 5:42 AM Dima Pasechnik <dimp...@gmail.com> wrote:
>>>>
>>>> This seems to be well-known issue, see e.g
>>>> https://github.com/pypa/virtualenv/issues/2027
>>>>
>>>> Are you on the most recent develop branch (9.3.beta7)?
>>>>
>>>> On Mon, Feb 8, 2021 at 9:20 AM Trevor Karn <trevor.k.k...@gmail.com> wrote:
>>>> >
>>>> > Hi,
>>>> >
>>>> > I'm trying to build Sage from the source code. I cloned it from git, and 
>>>> > tried to build from the develop branch using make from the sage 
>>>> > directory. I ran into trouble building cython. The error message 
>>>> > suggested that I email this group. Does anyone have any advice on how to 
>>>> > proceed?
>>>> >
>>>> > I am using macOS Big Sur 11.2 on a MacBook Air.
>>>> >
>>>> > The log file is attached, this is from a second run - it failed once, 
>>>> > and I tried running make a second time without any changes and this is 
>>>> > the log from the second run, which returns the same error just without 
>>>> > all of the info before it (eg. the flint installation).
>>>> >
>>>> > Thanks so much.
>>>> >
>>>> > Best,
>>>> > Trevor
>>>> >
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>>>
>>> --
>>> Best,
>>>
>>> Trevor
>>>
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