A discusssion of mutating versions of GMP (etc) is emphasized  in
material here
http://www.mail-archive.com/sage-devel@googlegroups.com/msg27570.html

Note that converting (in applications of these Lisp programs) to gmp
integers and back is not something
you do very often. After all, if you are doing gmp arithmetic, about
the only
time you need conversion is (maybe) to set up the problem and (maybe)
to print the results. I would guess the same holds for Sage.

Writing the conversion code in lisp is not difficult. I don't know why
it should
be difficult in Python, unless you have only fixed-precision
integers.
Feel free to adopt it.

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