The build finally worked on the downloaded source when adding to the 
./configure command as proposed bu Rob and making use of the macport additional 
libraries (likely from XZ).

I could build and install htslib, samtools , and bcftools v1.6 and have now 
running samtools, bcftools and htsfile executables in my bin folder (and more 
;-))

> ./configure CPPFLAGS='-I /opt/local/include’

Thanks to all for your help.

Stephane

 <http://www.nucleomics.be/>            Stephane Plaisance, Ph.D

Address: Herestraat 49, O&N4, Post Box 816, Room nr. 404-24 / 08.428, 3000 
Leuven - Belgium
Tel: +32 (0)16 37 31 26
Lync: +32 (0)16 32 00 60
Fax: +32 (0)16 37 31 29
Web: www.nucleomics.be <http://www.nucleomics.be/>

> On 21 Nov 2017, at 13:03, samtools-help-requ...@lists.sourceforge.net wrote:
> 
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> Today's Topics:
> 
>   1. Re: Issue Building htslib and samtools 1.6 on HighSierra OSX
>      10.13.1 (John Marshall)
>   2. Re: Issue Building htslib and samtools 1.6 on HighSierra OSX
>      10.13.1 (Robert Davies)
> 
> 
> ----------------------------------------------------------------------
> 
> Message: 1
> Date: Mon, 20 Nov 2017 17:08:24 +0000
> From: John Marshall <john.w.marsh...@glasgow.ac.uk>
> To: VIB | Stephane Plaisance <stephane.plaisa...@vib.be>
> Cc: "samtools-help@lists.sourceforge.net"
>       <samtools-help@lists.sourceforge.net>
> Subject: Re: [Samtools-help] Issue Building htslib and samtools 1.6 on
>       HighSierra OSX 10.13.1
> Message-ID: <c7433d8c-9685-4986-81a0-059e1df06...@glasgow.ac.uk>
> Content-Type: text/plain; charset="us-ascii"
> 
> On 17 Nov 2017, at 15:00, VIB | Stephane Plaisance 
> <stephane.plaisa...@vib.be<mailto:stephane.plaisa...@vib.be>> wrote:
> I did install before but after upgrading to high Sierra I am lacking some dev 
> dependencies (Xcode is installed)
> I tried installing xz using macport and got the error below (there is no port 
> with -dev)
> [...]
> checking for BZ2_bzBuffToBuffCompress in -lbz2... yes
> checking for lzma.h... no
> checking for lzma_easy_buffer_encode in -llzma... yes
> 
> As the second "yes" here indicates, macOS does in fact natively include a 
> liblzma shared library and in principle you should be able to use it without 
> needing to install another XZ via Brew or MacPorts. However it does not 
> provide the header files needed to compile code (like HTSlib) that uses the 
> XZ functions. You might like to try applying this pull request:
> 
> https://github.com/samtools/htslib/pull/628
> 
> which adds the bare minimum to HTSlib to enable building against macOS's 
> native liblzma.
> 
>    John
> -------------- next part --------------
> An HTML attachment was scrubbed...
> 
> ------------------------------
> 
> Message: 2
> Date: Mon, 20 Nov 2017 17:20:35 +0000 (GMT)
> From: Robert Davies <r...@sanger.ac.uk>
> To: VIB | Stephane Plaisance <stephane.plaisa...@vib.be>
> Cc: samtools-help@lists.sourceforge.net
> Subject: Re: [Samtools-help] Issue Building htslib and samtools 1.6 on
>       HighSierra OSX 10.13.1
> Message-ID:
>       <alpine.deb.2.10.1711201717540.3...@deskpro109045.internal.sanger.ac.uk>
>       
> Content-Type: TEXT/PLAIN; charset=US-ASCII; format=flowed
> 
> On Fri, 17 Nov 2017, VIB | Stephane Plaisance wrote:
> 
>> Thanks Robert for the rapid feedback, I tried but it die not fix it.
>> I seem to have an issue with gcc
> 
> Ah, sorry.  My instructions were wrong.  It should have been:
> 
> ./configure CPPFLAGS='-I /opt/local/include'
> 
> 
> This is what happens when you can't type it in first to check that it 
> works...
> 
> 
> Rob Davies              r...@sanger.ac.uk
> The Sanger Institute    http://www.sanger.ac.uk/
> Hinxton, Cambs.,        Tel. +44 (1223) 834244
> CB10 1SA, U.K.          Fax. +44 (1223) 494919
> 
> 
> -- 
> The Wellcome Trust Sanger Institute is operated by Genome Research 
> Limited, a charity registered in England with number 1021457 and a 
> company registered in England with number 2742969, whose registered 
> office is 215 Euston Road, London, NW1 2BE. 
> 
> 
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