I remember hearing in the early 1990s that some people had a natural resistance to AIDS. They would get the HIV virus. It would be detectable. But even without treatment, they never acquired full-blown AIDS.
On Jul 10, 2010, at 1:38 AM, "Mr. Worf" <[email protected]> wrote: > That would make sense that some folks in Africa would have a natural immunity > to it. Like folks in Europe that are naturally immune to the black plague. > > > On Fri, Jul 9, 2010 at 4:23 PM, Kelwyn <[email protected]> wrote: > I saw this in the Wall Street Journal (and posted it practically everywhere > but here). The HIV antibodies were discovered in the cells of a 60-year-old > African-American gay man, known in the scientific literature as Donor 45, > whose body made the antibodies naturally. That is absolutely wild to me! > > ~rave! > > --- In [email protected], "Mr. Worf" <hellomahog...@...> wrote: > > > > Scientists discover antibodies that neutralize over 91 percent of HIV > > strains > > > > By Darren Quick <http://www.gizmag.com/author/darren-quick/> > > > > *19:58 July 8, 2010* > > > > 1 > > Picture<http://www.gizmag.com/antibodies-neutralize-over-90-percent-of-hiv-strains/15662/picture/117491/> > > [image: The atomic structure of the antibody VRC01 (blue and green) > > binding to HIV (grey and red) > > ...]<http://www.gizmag.com/antibodies-neutralize-over-90-percent-of-hiv-strains/15662/picture/117491/> > > > > The atomic structure of the antibody VRC01 (blue and green) binding to HIV > > (grey and red) (Image: NIAID VRC) > > Find an ASO Near > > You<http://googleads.g.doubleclick.net/aclk?sa=l&ai=BxH1kZow3TMjfF4jSjQTH-a30A-q3m2_mq6r1DcCNtwGg-IkBEAEYASCz3PoBKAQ4AFDj7KDL-v____8BYMmO8IbIo6AZsgEOd3d3Lmdpem1hZy5jb226AQozMDB4MjUwX2pzyAEB2gGlAWh0dHA6Ly93d3cuZ2l6bWFnLmNvbS9hbnRpYm9kaWVzLW5ldXRyYWxpemUtb3Zlci05MC1wZXJjZW50LW9mLWhpdi1zdHJhaW5zLzE1NjYyLz91dG1fc291cmNlPUdpem1hZytTdWJzY3JpYmVycyZ1dG1fY2FtcGFpZ249OTE5MjY5NTRhZC1VQS0yMjM1MzYwLTQmdXRtX21lZGl1bT1lbWFpbMgC1rnhEqgDAegD8QToA7gD6AMt6APvCegD-AT1AwAAAET1AwACAAA&num=1&sig=AGiWqtyp3A5Yq3HMU1O2krjMxJ78-3Y7sA&client=ca-pub-1607124478120364&adurl=http://www.HIVTreatmentIsPower.com%3Fs_kwcid%3DTC%7C6887%7Csupport%2520for%2520hiv%7Cwww.gizmag.com%7CC%7Cb%7C3646087206>- > > www.HIVTreatmentIsPower.com<http://googleads.g.doubleclick.net/aclk?sa=l&ai=BxH1kZow3TMjfF4jSjQTH-a30A-q3m2_mq6r1DcCNtwGg-IkBEAEYASCz3PoBKAQ4AFDj7KDL-v____8BYMmO8IbIo6AZsgEOd3d3Lmdpem1hZy5jb226AQozMDB4MjUwX2pzyAEB2gGlAWh0dHA6Ly93d3cuZ2l6bWFnLmNvbS9hbnRpYm9kaWVzLW5ldXRyYWxpemUtb3Zlci05MC1wZXJjZW50LW9mLWhpdi1zdHJhaW5zLzE1NjYyLz91dG1fc291cmNlPUdpem1hZytTdWJzY3JpYmVycyZ1dG1fY2FtcGFpZ249OTE5MjY5NTRhZC1VQS0yMjM1MzYwLTQmdXRtX21lZGl1bT1lbWFpbMgC1rnhEqgDAegD8QToA7gD6AMt6APvCegD-AT1AwAAAET1AwACAAA&num=1&sig=AGiWqtyp3A5Yq3HMU1O2krjMxJ78-3Y7sA&client=ca-pub-1607124478120364&adurl=http://www.HIVTreatmentIsPower.com%3Fs_kwcid%3DTC%7C6887%7Csupport%2520for%2520hiv%7Cwww.gizmag.com%7CC%7Cb%7C3646087206> > > An ASO can provide HIV/AIDS support in many areas. 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As a consequence > > of these changes, an enormous number of HIV variants exist worldwide. > > However, there are a few surface areas that remain nearly constant across > > all variants of HIV and scientists have now discovered two potent human > > antibodies that attach to one of these sites and can stop more than 90 > > percent of known global HIV strains from infecting human cells in the > > laboratory. > > > > Led by a team from the National Institute of Allergy and Infectious > > Diseases<http://www.niaid.nih.gov/>(NIAID) Vaccine Research Center > > (VRC), the scientists found two naturally > > occurring, powerful antibodies called VRC01 and VRC02 in an HIV infected > > individual's blood using a novel molecular device they developed that hones > > in on the specific cells that make antibodies against HIV. The device is an > > HIV protein that the scientists modified so it would react only with > > antibodies specific to the site where the virus binds to cells it infects. > > > > The scientists found that VRC01 and VRC02 neutralize more HIV strains with > > greater overall strength than previously known antibodies to the virus. > > According to the scientists, these antibodies could be used to design > > improved HIV vaccines, or could be further developed to prevent or treat HIV > > infection. The method used to find these antibodies could be applied to > > isolate therapeutic antibodies for other infectious diseases as well. > > > > The researchers also determined the atomic-level structure of VRC01 when it > > is attaching to HIV. This has enabled the team to define how the antibody > > works and to precisely locate where it attaches to the virus. With this > > knowledge, they have begun to design components of a candidate vaccine that > > could teach the human immune system to make antibodies similar to VRC01 that > > might prevent infection by the vast majority of HIV strains worldwide. > > > > One of the few identified areas on the HIV’s surface that remains constant > > across all variants is called CD4 binding site. It is located on the surface > > spikes used by HIV to attach to immune system cells and infect them. The > > VRC01 and VRC02 antibodies found by the scientists block HIV infection by > > attaching to the CD4 binding site, preventing the virus from latching onto > > immune cells. > > > > “The antibodies attach to a virtually unchanging part of the virus, and > > this > > explains why they can neutralize such an extraordinary range of HIV > > strains,†says Dr. Mascola, the deputy director of the VRC. > > > > With these antibodies in hand, a team led by Dr. Kwong, chief of the > > structural biology section at the VRC, determined the atomic-level molecular > > structure of VRC01 when attached to the CD4 binding site. They then examined > > this structure in light of natural antibody development to ascertain the > > steps that would be needed to elicit a VRC01-like antibody through > > vaccination. > > > > Antibody development begins with the mixing of genes into new combinations > > within the immune cells that make antibodies. Examination of the structure > > of VRC01 attached to HIV suggested that, from a genetic standpoint, the > > immune system likely could produce VRC01 precursors readily. The researchers > > also confirmed that VRC01 does not bind to human cells â€" a characteristic > > that might otherwise lead to its elimination during immune development, a > > natural mechanism the body employs to prevent autoimmune disease. > > > > In the final stage of antibody development, antibody-producing B cells > > recognize specific parts of a pathogen and then mutate, or mature, so the > > antibody can bind to the pathogen more firmly. VRC01 precursors do not bind > > tightly to HIV, but rather mature extensively into more powerfully > > neutralizing forms. This extensive antibody maturation presents a challenge > > for vaccine design. In their paper, Dr. Kwong and colleagues explore how > > this challenge might be addressed by designing vaccine components that could > > guide the immune system through this stepwise maturation process and > > facilitate the generation of a VRC01-like antibody from its precursors. The > > scientists currently are performing research to identify these components. > > > > “The discoveries we have made may overcome the limitations that have long > > stymied antibody-based HIV vaccine design,†says Dr. Kwong. > > > > A pair of articles about these findings appear in the online edition of * > > Science <http://www.sciencemag.org/>*. > > > > > > -- > > Celebrating 10 years of bringing diversity to perversity! > > Mahogany at: http://groups.yahoo.com/group/mahogany_pleasures_of_darkness/ > > > > > > > ------------------------------------ > > Post your SciFiNoir Profile at > http://groups.yahoo.com/group/scifinoir2/app/peoplemap2/entry/add?fmvn=mapYahoo! > Groups Links > > > > > > > -- > Celebrating 10 years of bringing diversity to perversity! > Mahogany at: http://groups.yahoo.com/group/mahogany_pleasures_of_darkness/ >
