Brian, I just saw your post from April to the scrypt mailing list. (I signed up and was browsing the archives.) You've probably found it on your own by now, but FYI there are Python bindings in the py-scrypt package: http://pypi.python.org/pypi/scrypt/ (source here: https://bitbucket.org/mhallin/py-scrypt)
That module exposes `encrypt`, `decrypt`, and `hash` functions which call, respectively, `scryptenc_buf`, `scryptdec_buf`, and `crypto_scrypt`. Cheers, Kevin
