Re: Low cal for long life?
At 03:42 PM 4/20/2004, you wrote: I won't be trying this: http://www.msnbc.msn.com/id/4783035/ Tom Beck (PBS show about low cal diets and long life) http://tinyurl.com/2vvvq Doctor featured on the show. He was born June 29, 1924 and I assume still going strong: http://www.walford.com/ There was a report last week, a mouse was given a normal die for 3/4 of it's life, was showing signs of aging. Then they started his restricted diet and now is at 120% of life span and is vigerous. Kevin T. - VRWC But yeah, not thinking about doing that myself. Yet. ___ http://www.mccmedia.com/mailman/listinfo/brin-l
Re: Low cal for long life?
On Tue, Apr 20, 2004 at 10:16:08PM -0500, The Fool wrote: They are called telomeres. They are on the ends of chromosomes. Every time a cell divides they shorten. For that to link with what I was suggesting, there needs to be a correlation between faster metabolic rate and cell division / telomere shortening rate. Is there? Do cells divide more quickly when your metabolism speeds up, or more slowly when it slows down due to, for example, restricted calorie intake? -- Erik Reuter http://www.erikreuter.net/ ___ http://www.mccmedia.com/mailman/listinfo/brin-l
Re: Low cal for long life?
-- From: Erik Reuter [EMAIL PROTECTED] On Tue, Apr 20, 2004 at 10:16:08PM -0500, The Fool wrote: They are called telomeres. They are on the ends of chromosomes. Every time a cell divides they shorten. For that to link with what I was suggesting, there needs to be a correlation between faster metabolic rate and cell division / telomere shortening rate. In either case telomere length is the determining factor for how long the individual cell lives. Is there? Do cells divide more quickly when your metabolism speeds up, or more slowly when it slows down due to, for example, restricted calorie intake? It's likely that increases in metabolism also increase the production of waste products / free radicals which damage cells. But there are also some systemic effects. Scientists have created a Methuselah mouse, that has lived more than four years (normal mice die by 2) in is healthy. They engineered changes to limit the production of insulin. The mouse is smaller than normal and cold, but otherwise still healthy. Therefore there seems to be correlation with insulin production and longevity (which is what these new diets attempt--Atkins, southbeach, Zone--that all try to limit production of insulin, consumption of simple-carbs). Insulin certainly affects the growth rate of fat cells. ___ http://www.mccmedia.com/mailman/listinfo/brin-l
Re: Low cal for long life?
-- From: Erik Reuter [EMAIL PROTECTED] On Wed, Apr 21, 2004 at 06:06:23PM -0500, The Fool wrote: Erik wrote: For that to link with what I was suggesting, there needs to be a correlation between faster metabolic rate and cell division / telomere shortening rate. Is there? In either case telomere length is the determining factor for how long the individual cell lives. That does not answer the question. Insulin certainly affects the growth rate of fat cells. Huh? What do you mean exactly by growth rate, and what does that have to do with whether a faster metabolic rate results in increased rate of telomere shortening? --- When you eat food it is converted into glucose, raising the amount of glucose in the blood. The Body uses that glucose or raises the amount of Insulin in the blood which converts the glucose into fat. Cells have receptors for insulin, which allows them to regulate how fat is stored. Metabolic rate is the rate that you burn calories, which is directly related to blood sugar / insulin levels. Muscle / fat mass affects the metabolic rate. Caloric-restriction directly effects the blood-sugar / insulin system. The Methuselah mouse longevity is also affected by insulin levels. ___ http://www.mccmedia.com/mailman/listinfo/brin-l
Low cal for long life?
I won't be trying this: http://www.msnbc.msn.com/id/4783035/ -- Tom Beck my LiveJournal: http://www.livejournal.com/users/tomfodw/ I always knew I'd see the first man on the Moon. I never thought I'd see the last. - Dr. Jerry Pournelle -- ___ http://www.mccmedia.com/mailman/listinfo/brin-l
Re: Low cal for long life?
On 20 Apr 2004, at 8:42 pm, Thomas Beck wrote: I won't be trying this: http://www.msnbc.msn.com/id/4783035/ So I just need to work out how to combine that with Atkins and I could live forever! -- William T Goodall Mail : [EMAIL PROTECTED] Web : http://www.wtgab.demon.co.uk Blog : http://radio.weblogs.com/0111221/ Misuse of IMPs leads to strange, difficult-to-diagnose bugs. - Anguish et al. Cocoa Programming ___ http://www.mccmedia.com/mailman/listinfo/brin-l
Re: Low cal for long life?
So I just need to work out how to combine that with Atkins and I could live forever! Reminds me of the old joke, Wanna live longer? Give up rich food, alcohol, desserts, sex, and fun. You won't live longer, it'll just FEEL longer. -- Tom Beck my LiveJournal: http://www.livejournal.com/users/tomfodw/ I always knew I'd see the first man on the Moon. I never thought I'd see the last. - Dr. Jerry Pournelle -- ___ http://www.mccmedia.com/mailman/listinfo/brin-l
Re: Low cal for long life?
Jeez, they said one guy went from 3000 Kcal to 1900 Kcal for this diet. Is that all??? Lessee...what could I cut from my diet to reach thatoh yeah...soda... Damon. ___ http://www.mccmedia.com/mailman/listinfo/brin-l
Re: Low cal for long life?
I wonder if their might be a built in mechanism in the body something like a metabolic clock ticking along. You only get X ticks of the metabolic clock. If you slow your metabolism down, your metabolic clock ticks more slowly and you live longer (all on average, of course). -- Erik Reuter http://www.erikreuter.net/ ___ http://www.mccmedia.com/mailman/listinfo/brin-l
Re: Low cal for long life?
-- From: Erik Reuter [EMAIL PROTECTED] I wonder if their might be a built in mechanism in the body something like a metabolic clock ticking along. You only get X ticks of the metabolic clock. If you slow your metabolism down, your metabolic clock ticks more slowly and you live longer (all on average, of course). --- They are called telomeres. They are on the ends of chromosomes. Every time a cell divides they shorten. When they get very short, the cell dies. The probable reason for this is because of cancer (really old cells that have divided a lot are more prone to chromosome damage, and have collected a lot more toxins / chemicals that can't be broken down or eliminated by the cell which will tend to lead to cancer). Also there is a certain amount of redundancy in all your various organs. Over time this redundancy gets used as damage accumulates until organ failure occurs. Also their is a limited supply of adult stem cells that repair damage in various ways. They are limited by telomeres, and when they are used up damage accrues. I posted a link last month that showed a link between adult stem cells and heart disease. So the idea is to not deplete the stores of adult stem cells, and to not cause unnecessary damage to cells from free radicals. ___ http://www.mccmedia.com/mailman/listinfo/brin-l
