[ccp4bb] 47th Annual Mid-Atlantic Macromolecular Crystallography Meeting, June 7th-9th, University of Maryland , Baltimore

[Pazgier, Marzena]

Registration site is still open for 47th Annual Mid-Atlantic Macromolecular 
Crystallography Meeting, June 7th-9th, University of Maryland , Baltimore.
Registration and abstract submission can be done through meeting website:

https://www.eventbrite.com/e/47th-mid-atlantic-crystallography-meeting-university-of-maryland-june7-9th-2017-tickets-30935125794

[ccp4bb] Opportunities at Schrödinger: Senior Scientist, Cryo-EM Model Fitting

[Frank Pagliaro]

Schrödinger, a computational chemistry company funded in part by Bill
Gates, has over 300 engineers, computational chemists, medicinal chemists,
structural biologists, biochemists, biologists and support staff, all
dedicated to revolutionizing drug discovery through the development and use
of breakthrough computational methods. Through significant long-term
investments in basic research, we have made scientific advancements across
many areas of drug discovery and have contributed hundreds of peer-reviewed
scientific publications, which are frequently among the most heavily cited
in their fields. These advancements have been instrumental in the success
of our structure-based drug discovery efforts (
https://www.schrodinger.com/publications,  https://www.schrodinger.com/news).


We are seeking an expert in developing and applying methods to create and
refine structural models created from near-atomic-resolution
single-particle cryo-EM experiments of proteins. This expert will work from
our New York office. The ideal candidate will have a demonstrated ability
to develop and validate algorithms to locally refine protein models using a
combination of experimental data and statistical or physical potentials.

*Responsibilities:*

- Work as part of a collaborative team to create and validate new
technologies designed to produce high-confidence structural models from
near-atomic-resolution cryo-EM of proteins

- Work with the drug discovery group to deploy these new technologies to
active projects

*Requirements:*

- Ph.D. in computational chemistry, biochemistry, biophysics, or a related
field with peer-reviewed publications in the field

- Experience working with and/or extending existing protein structure
prediction or homology modeling packages such as Rosetta, Modeller, Prime,
etc.

- Experience working with data from single-particle cryo-electron microscopy

- Experience with scripted or compiled programming languages

- Excellent communication skills and a demonstrated ability to work as part
of a team

*Preferred Skills:*

- Experience working with pharmaceutically relevant systems such as
kinases, GPCRs, transferases, etc

- Broad knowledge of computational chemistry techniques and their
applications to the drug discovery process

- Object oriented software development experience following good
engineering practices

Benefits include medical, dental, 401(k), flexible spending account,
vacation, tuition reimbursement, and a flexible work schedule.


*Schrödinger is an equal opportunity employer.*

If interested, please apply through our website:
https://www.schrodinger.com/careers/scientists/senior-scientist-cryo-em-model-fitting

-- 
Frank Pagliaro
Schrödinger, Inc.
120 W 45th St
New York, NY 10036
(774) 212-2478
frank.pagli...@schrodinger.com

[ccp4bb] Opportunities at Schrödinger: Cryo-EM Refinement Specialist

[Frank Pagliaro]

Schrödinger, a computational chemistry company funded in part by BIll
Gates, has over 300 engineers, computational chemists, medicinal chemists,
structural biologists, biochemists, biologists and support staff, all
dedicated to revolutionizing drug discovery through the development and use
of breakthrough computational methods.  Through significant long-term
investments in basic research, we have made scientific advancements across
many areas of drug discovery and have contributed hundreds of peer-reviewed
scientific publications, which are frequently among the most heavily cited
in their fields.  These advancements have been instrumental in the success
of our structure-based drug discovery efforts, with three of our programs
already in clinical trials and a fourth expected later this year. (
https://www.schrodinger.com/publications, https://www.schrodinger.com/news)

We are now seeking a cryo-electron microscopy refinement specialist to join
this interdisciplinary team in New York. This specialist will help us to
combine our expertise in structure-based drug discovery with current
breakthroughs in structural biology to further accelerate the drug
discovery process.

*Responsibilities:*

-Refine and evaluate high resolution single particle cryo-EM data sets

-Actively participate in internal and collaborative structure-based drug
discovery projects

-Work with the internal software development team to improve Schrödinger’s
structure-based drug discovery technologies

*Requirements:*

-Ph.D. in structural biology, chemistry, biophysics, or a related field

-Hands-on experience working with single particle cryo-EM data collection
for biological specimens

-Experience working with single particle cryo-EM refinement packages (EMAN,
FreeAign, Relion, CryoSPARC, etc.), to refine high resolution data sets
from biological specimens

-Strong communication skills

*Preferred Skills:*

-Experience with methods to account for global and local structural
heterogeneity in single particle cryo-EM data

-Knowledge of molecular modeling theory and applications

-Experience with pharmaceutical or biotechnology problems

-Python programming experience


Benefits include medical, dental, 401(k), flexible spending account,
vacation, tuition reimbursement, and a flexible work schedule.

*Schrödinger is an equal opportunity employer.*

If interested, please apply through our website:
https://www.schrodinger.com/careers/other-positions/cryo-em-refinement-specialist

-- 
Frank Pagliaro
Schrödinger, Inc.
120 W 45th St
New York, NY 10036
(774) 212-2478
frank.pagli...@schrodinger.com

[ccp4bb] Postdoctoral Associate opportunity

[Estrada, D. Fernando]

Dear Colleagues,

I'd like to announce that the application window for the postdoctoral associate 
opening in my lab will soon close. Our principle interest is the structural and 
function of vitamin D related cytochromes P450.
Applicants with a background in protein crystallography or membrane protein 
production are especially encouraged to apply.  More details on the position 
can be found here: https://www.ubjobs.buffalo.edu/postings/6006, or by 
searching job posting #R171.

Sincerely,
DF Estrada

D. Fernando 
Estrada,
 PhD
Assistant Professor
Department of Biochemistry
Jacobs School of Medicine and Biomedical Sciences
University at Buffalo
Buffalo, NY 14214-3000
716-829-2767 (Office)
dfest...@buffalo.edu

[ccp4bb] AIC Cryo-EM international School 2017 - Deadlines approaching!

[Federico Forneris]

Dear all,

this is the second announcement of the International School "Bridging the
Gap between Cryo-EM and Crystallography" that will be held in Pavia, 3-7
September 2017. http://www.cristallografia.org/aicschool2017 

 

This school will offer the opportunity to young researchers in biochemistry
or structural biology at the PhD/postdoctoral level to approach the
fundamental questions arising from the cryo-EM experiment setup. Central
topics will include evaluation sample suitability for analysis and its
preparation, choice of appropriate instrumentation for single particle,
tomography or electron diffraction approaches, data processing and
interpretation of results. A showcase of recent results will contour the
tutorial sessions.

 

The school program is almost finalized and, given the enthusiastic reply
from speakers, tutors and the applicants who already registered until now,
we are confident this event will be an excellent opportunity for many
scientists who want to approach and learn the basics of cryo-electron
microscopy. We have received official sponsorship from the International
Union for Crystallography (IUCr) which allows us to offer travel bursaries
and awards to outstanding participants based on their CV and motivation
letters. DEADLINE FOR BURSARY APPLICATIONS: May 15th, 2017.

 

For information, program and registration details please visit
http://www.cristallografia.org/aicschool2017. More specific enquiries can be
discussed via e-mail to my address or to aicsch...@cristallografia.org 

 

We look forward to hosting you in Pavia and discuss about Cryo-EM in
September.

On behalf of all school organizers,

Very best wishes,

F.

 

Federico Forneris, PhD


The Armenise-Harvard Laboratory of Structural Biology

Dept. Biology and Biotechnology
University of Pavia

Via Ferrata, 9

I-27100 Pavia - ITALY
  http://fornerislab.unipv.it

 

 

 

 

[ccp4bb] Research Technician Position in Structural Biology at CNIO (Spanish National Cancer Research Centre, Madrid, Spain)

[Munoz.Ines]

Dear CCP4bb members,
I would really appreciate if you could share the following info regarding an 
available position in my lab with any potential candidates.
Best wishes,
Inés.

Research Technician Position in Structural Biology at CNIO (Spanish National 
Cancer Research Centre, Madrid, Spain)
A 3 years NIH-funded research technician position is immediately available for 
a highly motivated structural biologist in the Crystallography and Protein 
Engineering Unit at the CNIO’s Structural Biology and Biocomputing Programme.
The Unit provides state-of-the-art infrastructures for protein production and 
posterior structural studies, which includes high-throughput protein 
crystallization instrumentation.
The successful applicant will be involved in a number of drug discovery 
projects that involves all the stages that lead to the determination of protein 
structures in the presence of inhibitors for further development. The candidate 
must have a strong background in molecular biology, protein 
expression/purification, X-ray crystallography and SAXS. Interested candidates 
should email perso...@cnio.es (Reference TSCPE) with a 
cover letter describing the candidate's previous work experience and research 
interests, CV, and contact details of three referees.
Further details on how to apply can be found here:
http://www.cnio.es/ing/empleo/ofertas-amp.asp?codigo=1895


Inés G. Muñoz, Ph.D.
Head of Crystallography and Protein Engineering Unit
Spanish National Cancer Research Centre (CNIO)
Structural Biology and Biocomputing Programme
Melchor Fernández Almagro 3
28029 Madrid. SPAIN.
Tel: +34 912246900 ext 3020
Email: imu...@cnio.es
https://www.cnio.es/es/grupos/plantillas/presentacion.asp?grupo=50009748







Hazte Amigo del CNIO / Become a Friend of CNIO
www.cnio.es/es/colaborar/comocolaborar.asp

Facebook: Hazte Amigo del CNIO
@HazteAmigoCNIO |  
@CNIO_Cancer

[http://www.cnio.es/img/signature/hadc.gif] 


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[ccp4bb] ccp4 release 7.0 update 037

[Charles Ballard]

Dear All

new update containing

* DIALS 1.5.1

* XIA2 0.5.277

All the best

CCP4 Core team.

[ccp4bb] Research technician post (initially 4y) available in the Berger laboratory, University of Bristol UK

[kapil gupta]

Dear CCP4bb and CCPEM members,

One Research technician position is immediately available in the Berger
laboratory, University of Bristol UK.

The Berger laboratory researches the structure and mechanism of key
multiprotein complexes in human gene expression and develops enabling
methods for their study.

We are seeking a Research Technician to actively participate in the
ambitious research projects in our laboratory. The successful candidate
will engage in designing and preparing DNA constructs, and will express,
purify and characterize proteins and their complexes for high-resolution
structural and functional study. Showing a high level of organization and
independence, the successful candidate will manage the molecular biology
and protein purification platforms including ordering of consumables, and
assist in operating the eukaryotic expression facility in the Berger lab.

The role holder will work under the supervision of the PI and will actively
embrace the responsibility of managing technology platforms underpinning
all research in the Berger lab.

For further information follow link: http://www.jobs.ac.uk/
job/BBD342/research-technician

For informal enquiries, please contact: Prof. Imre Berger, Tel: 0117 394
1857, imre.ber...@bristol.ac.uk,

or
Dr. Kapil Gupta, kg16...@bristol.ac.uk
.

Dr Kapil Gupta on behalf of
Prof. Imre Berger PhD HDR FRSB
Chair of Biochemistry
Wellcome Trust Senior Investigator
Deputy Director, BrisSynBio Centre

School of Biochemistry
Biomedical Sciences Building
University of Bristol
University Walk
Bristol
BS8 1TD
Tel: 0044 (0) 117 39 41857
Mobile: 0044 (0) 79 0720 8697
imre.ber...@bristol.ac.uk 
http://www.bris.ac.uk/biomedical-sciences/ 

A top 5 UK university with leading employers (2015)
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