[ccp4bb] Open-rank, tenure-line faculty position

[Hasan, Syed Saif]

Dear Colleagues,

The Institute for Bioscience & Biotechnology Research (IBBR) and the University 
of Maryland, College Park Department of Chemistry & Biochemistry invite 
applications for an open-rank, tenure-line faculty position in structural 
biology, with an emphasis in the area of biomolecular cryo-electron microscopy 
(cryoEM), starting August 2021. The faculty member will base their research 
program on the IBBR campus in Rockville, Maryland, and hold joint appointments 
with IBBR and the Department of Chemistry & Biochemistry at College Park. The 
criteria for selection will be proven excellence and potential for impact 
through original research, scholarship, and teaching. Successful candidates 
will be expected to develop a vigorous externally funded research program and 
have a demonstrated commitment to teaching and mentorship at the undergraduate 
and graduate levels.

IBBR is a joint research institute of the University of Maryland and the 
National Institute of Standards and Technology (NIST), centrally located in 
Maryland’s biotechnology corridor. The Institute’s mission is to conduct 
groundbreaking research in the field of biotechnology that generates innovative 
solutions to major scientific and engineering challenges. The Institute has a 
long history of excellence in biomolecular structure-function relationships. 
Current research programs center on the biomolecular engineering of vaccines, 
biotherapeutics, and diagnostics; biomolecular measurement science; and disease 
pathways and biomolecular targets. The available instrumentation at IBBR 
includes a 200 kV Talos Arctica cryoEM with a Falcon 3EC direct electron 
detector and a 200 kV Glacios cryoEM with a Gatan K3 direct electron detector 
and a Volta phase plate. The University of Maryland College Park has a Zeiss EM 
10 CA TEM equipped with a tilt stage and a JEOL 100CX II TEM. IBBR 
instrumentation for sample preparation was recently upgraded with a Thermo 
Fisher Scientific Vitrobot Mark IV and a Gatan cryoplunge 3. IBBR also 
maintains a high-performance computing cluster with a dedicated 750 TB parallel 
file system, and two dedicated 8-GPU nodes. These cryo-EM facilities complement 
other state-of-the-art instrumentation and expertise at IBBR, including NMR, 
X-ray crystallography, mass spectrometry, and solution X-ray scattering.

For details, please see this advertisement: https://ejobs.umd.edu/postings/80583

Best wishes,

Saif

S. Saif Hasan, PhD
Assistant Professor
Department of Biochemistry and Molecular Biology, University of Maryland School 
of Medicine
108 N. Greene Street, Baltimore MD 21201
https://www.medschool.umaryland.edu/profiles/Hasan-S-Saif-Hasan-Syed-Saif/

Associate Member
Program in Oncology, University of Maryland Marlene and Stewart Greenebaum 
Comprehensive Cancer Center (UMGCCC)
22 S. Greene Street, Baltimore MD 21201

Office and Laboratory Address:
Center for Biomolecular Therapeutics, Institute for Bioscience and 
Biotechnology Research (IBBR)
9600 Gudelsky Drive, Rockville MD 20850
https://www.ibbr.umd.edu/profiles/s-saif-hasan
Phone: 240-314-6396
Fax: 240-314-6225



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[ccp4bb] ideal ligands

[Bernhard Rupp]

Hi Fellows,

 

PDBeChem under 'ideal' coordinates returns a small molecule uranium atom
solution for BCR, LUT, and possibly other xanthophylls, eg.

ftp://ftp.ebi.ac.uk/pub/databases/msd/pdbechem_v2/B/BCR/BCR_ideal.pdb

while the representative files are ok.

 

Is this intended?

 

Thx, BR

--

Bernhard Rupp

  http://www.hofkristallamt.org/

b...@hofkristallamt.org  

+1 925 209 7429

+43 676 571 0536

--

Many plausible ideas vanish 

at the presence of thought

--

 




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[ccp4bb] Fwd: [ccp4bb] Postdoc position, Plant Hormone Transporting Membrane Proteins (Denmark)

[Mark J van Raaij]

in case it might be of interest for someone @CNB:


> Begin forwarded message:
> 
> From: Bjørn Panyella Pedersen 
> Subject: [ccp4bb] Postdoc position, Plant Hormone Transporting Membrane 
> Proteins (Denmark)
> Date: 5 February 2021 at 17:20:38 GMT+1
> To: CCP4BB@JISCMAIL.AC.UK
> Reply-To: Bjørn Panyella Pedersen 
> 
> Dear colleagues,
> I have an open postdoc position funded by the ERC (details below).
> Please pass this along to anyone who might be interested. Thanks!
> /Bjørn
> 
> Postdoctoral position in Structure of Plant Hormone Transporting Membrane 
> Proteins at Aarhus University, Denmark.
> 
> online posting:
> https://tinyurl.com/MBGpostdoc 
> 
> We are looking for a highly skilled and motivated postdoc with an interest in 
> working on plant hormone transporting membrane transporters and preferably 
> with a proven track record in the area of structural and/or functional 
> analysis of membrane proteins and an interest for plant biology.
> 
> Starting date is negotiable. Funding is available through an ERC grant for at 
> least 2 years of employment. An extension is possible for up to a total 
> maximum of 4 years of employment as a postdoc.
> 
> The position:
> The position seeks to strengthen ongoing activities in the laboratory of 
> Bjørn P. Pedersen on structure, related to the function and mechanism of 
> plant hormone-transporting membrane proteins as defined by the ERC project 
> MUM-GROW (pedersenlab.dk ). Exact project will be 
> shaped out in dialogue with top runners. The laboratory's interest is the 
> interplay between structure and function of transmembrane transport processes 
> with a focus on metabolite uptake systems, and the methods uses are primarily 
> crystallography and cryo-EM. The group is part of the Section of Structural 
> Biology at Aarhus University.
> 
> The candidate:
> A successful candidate has a relevant Ph.D. degree and a solid and documented 
> background in structural biology, biochemistry and/or biophysics. Experience 
> with membrane protein expression and purification is favored, and the 
> candidate must demonstrate an ability and interest to work with membrane 
> proteins with a structural aim. Applicants should be ambitious, show strong 
> collaborative skills, and be able to take initiatives and responsibility 
> within the work environment.
> 
> The successful candidate is offered:
> - access to a well-developed research infrastructure.
> - a research climate inviting lively, open and critical discussion within and 
> across different fields of research.
> - a working environment with teamwork, close working relations, network 
> activities among young scientists and social activities.
> - a workplace characterized by professionalism, equality and a healthy 
> work-life balance.
> 
> The city:
> In Aarhus you have easy access to beautiful nature, an exciting culture and 
> city life as well as a safe environment for children - a great place for the 
> whole family. The city of Aarhus has everything you need: exciting national 
> and international jobs, delightful residential areas, a rich cultural life, 
> and beautiful surrounding landscape of woods and coastline that make Aarhus a 
> wonderful place to live and work. See https://international.au.dk/life/ 
>  for details. Aarhus University offers 
> relocation service to international researchers. You can read more about it 
> at https://international.au.dk/life/researcherscomingtoau/ 
> .
> 
> Deadline:
> All applications must be made online (https://tinyurl.com/MBGpostdoc 
> ) and received by March 1st 2021.
> 
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 
> 



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[ccp4bb] Postdoc position, Plant Hormone Transporting Membrane Proteins (Denmark)

[Bjørn Panyella Pedersen]

Dear colleagues,
I have an open postdoc position funded by the ERC (details below).
Please pass this along to anyone who might be interested. Thanks!
/Bjørn

Postdoctoral position in Structure of Plant Hormone Transporting Membrane 
Proteins at Aarhus University, Denmark.

online posting:
https://tinyurl.com/MBGpostdoc

We are looking for a highly skilled and motivated postdoc with an interest in 
working on plant hormone transporting membrane transporters and preferably with 
a proven track record in the area of structural and/or functional analysis of 
membrane proteins and an interest for plant biology.

Starting date is negotiable. Funding is available through an ERC grant for at 
least 2 years of employment. An extension is possible for up to a total maximum 
of 4 years of employment as a postdoc.

The position:
The position seeks to strengthen ongoing activities in the laboratory of Bjørn 
P. Pedersen on structure, related to the function and mechanism of plant 
hormone-transporting membrane proteins as defined by the ERC project MUM-GROW 
(pedersenlab.dk). Exact project will be shaped out in dialogue with top 
runners. The laboratory's interest is the interplay between structure and 
function of transmembrane transport processes with a focus on metabolite uptake 
systems, and the methods uses are primarily crystallography and cryo-EM. The 
group is part of the Section of Structural Biology at Aarhus University.

The candidate:
A successful candidate has a relevant Ph.D. degree and a solid and documented 
background in structural biology, biochemistry and/or biophysics. Experience 
with membrane protein expression and purification is favored, and the candidate 
must demonstrate an ability and interest to work with membrane proteins with a 
structural aim. Applicants should be ambitious, show strong collaborative 
skills, and be able to take initiatives and responsibility within the work 
environment.

The successful candidate is offered:
- access to a well-developed research infrastructure.
- a research climate inviting lively, open and critical discussion within and 
across different fields of research.
- a working environment with teamwork, close working relations, network 
activities among young scientists and social activities.
- a workplace characterized by professionalism, equality and a healthy 
work-life balance.

The city:
In Aarhus you have easy access to beautiful nature, an exciting culture and 
city life as well as a safe environment for children - a great place for the 
whole family. The city of Aarhus has everything you need: exciting national and 
international jobs, delightful residential areas, a rich cultural life, and 
beautiful surrounding landscape of woods and coastline that make Aarhus a 
wonderful place to live and work. See https://international.au.dk/life/ for 
details. Aarhus University offers relocation service to international 
researchers. You can read more about it at 
https://international.au.dk/life/researcherscomingtoau/.

Deadline:
All applications must be made online (https://tinyurl.com/MBGpostdoc) and 
received by March 1st 2021.



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[ccp4bb] Structural Biology Postdoc in Targeted Protein Degradation at St. Jude

[Marcus Fischer]

*STRUCTURAL BIOLOGY postdoc project:*

*Small Molecule Degraders for Targeting Transcription Factor Drivers in
Childhood Cancers*



We are recruiting a postdoc for a multidisciplinary, collaborative project
that exploits targeted protein degradation (TPD) of pediatric cancer
targets using Molecular Glues (MG). TPD is an exciting and rapidly evolving
drug discovery paradigm that shows great promise for drugging currently
undruggable targets. In this recently funded 5-year project we are
developing novel MG approaches to target key transcription factor
dependencies in high-risk childhood acute leukemia and medulloblastoma.



We are looking for highly motivated, brilliant minds with curiosity and
skills to contribute structural biology insights that shed light on MG
interactions with ternary complexes of neosubstrates such as oncogenic
transcription factors. Such insights will aid target characterization, MG
hit optimization, structure-guided molecular design, all the way to
preclinical validation and subsequent clinical translation. These
structural biology efforts are integrated into a highly collaborative
environment comprised of chemists and pathologists, as well as
computational biologists, systems biologists and experimental in vitro/ in
vivo biologists that work closely together toward the common goal of
improving childhood cancer outcomes.



The project is housed in the Department of Chemical Biology and Therapeutics
,
and Structural Biology

at
St. Jude Children’s Research Hospital. It builds on strong investments into
a world-class infrastructure in structural and chemical biology. This is an
exciting time to join us and build a career while living in an affordable
city. This postdoc position is funded for 5 years.



Essential requirements:

-   PhD in structural biology

-   Independence in gene-to-structure workflow

o   Demonstrated proficiency in molecular biology, construct design,
protein biochemistry, expression (including insect cells), purification,
reconstitution and structural determination of ternary complexes

-   Strong background in X-ray crystallography

o   automation, optimization, crystallization robotics; synchrotron data
collection

o   structural analyses, representation and integration with other
biophysical data



Optional requirements:

-   Experience in cryoEM, xFEL or microED

-   Experience with computational approaches and *in silico* modelling
is desired



Please direct your questions and application package including a cover
letter, current CV, and 3 letters of reference to: Dr. Marcus Fischer (
marcus.fisc...@stjude.org).



https://www.stjude.org/fischer



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