[ccp4bb] Postdoc positions in structural analysis of trypanosome kinetochores, University of Oxford

2021-03-01 Thread Bungo Akiyoshi 
Dear Colleagues,

Two postdoc positions are available in my group at the Department of 
Biochemistry, University of Oxford.

We are seeking to appoint two outstanding individuals with PhD training in 
structural biology to reveal the structure and function of unconventional 
kinetoplastid kinetochore proteins. Although it was widely believed that all 
eukaryotes would have a conserved set of kinetochore proteins, we identified 
more than 20 uncharacterized kinetochore proteins (named KKT1–25) in 
Trypanosoma brucei and discovered that they constitute unconventional 
kinetochores specific to kinetoplastids, a group of evolutionarily-divergent 
eukaryotes (Akiyoshi and Gull, Cell 2014, Nerusheva and Akiyoshi Open Biol 
2016, Nerusheva et al., Open Biol 2019, Tromer et al., bioRxiv 2021). We are 
currently characterizing these KKT proteins using various techniques including 
cell biology, bioinformatics, super-resolution microscopy, biochemistry, 
biophysics, and structural biology (X-ray crystallography, NMR, electron 
tomography, and cryoEM/ET).

For more information, please click on the link below:
https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.jobspec?p_id=149534

Please contact me if you have any question.

Best wishes,
Bungo

--
Bungo Akiyoshi, PhD
Wellcome Trust Senior Research Fellow, EMBO YIP
Department of Biochemistry, University of Oxford
https://bungoakiyoshi.com/




To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1

This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list 
hosted by www.jiscmail.ac.uk, terms & conditions are available at 
https://www.jiscmail.ac.uk/policyandsecurity/

[ccp4bb] Computational Crystallography Newsletter – Jan. 2021

2021-03-01 Thread Nigel Moriarty 
Folks

The latest issue of the CCN is available on the website. Please consider
contributing to future issues.

The Computational Crystallography Newsletter (CCN) is an electronic
newsletter for structural biologists, and is published online every 6
months. Feature articles, meeting announcements and reports can be
submitted to me at any time for consideration. Submission of text by
email or word-processing files using the CCN templates is requested.
Past newsletters and a Microsoft Word template are available at
www.phenix-online.org/newsletter.

January 2021 

Articles
- HKLviewer, a new 3D reflection data viewer for CCTBX

- Running CCTBX and PyMOL in the same Jupyter Notebook


Short Communications
- PDB50: Celebrating 50 Years of the Protein Data Bank in 2021

- Lessons from using the Cambridge Structure Database: II – Element
specification X/Z

- The Importance of Being Positive: Charged ligands that bind nucleic acids


Fitting tips #20 - In-plane or out-of-plane H atom placement on the edges
of aromatic rings

Cheers

Nigel

---
Nigel W. Moriarty
Building 33R0349, Molecular Biophysics and Integrated Bioimaging
Lawrence Berkeley National Laboratory
Berkeley, CA 94720-8235
Phone : 510-486-5709 Email : nwmoria...@lbl.gov
Fax   : 510-486-5909  Web  : CCI.LBL.gov
ORCID : orcid.org/-0001-8857-9464



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1

This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list 
hosted by www.jiscmail.ac.uk, terms & conditions are available at 
https://www.jiscmail.ac.uk/policyandsecurity/

[ccp4bb] Correction - Postdoctoral position at ICTER in Warsaw, Poland (MCBO/34/2021)

2021-03-01 Thread Humberto Fernandes 


Dear all 



Small correction on the information bellow. 

To apply, please send the requested documents to [ 
mailto:icter_j...@ichf.edu.pl | icter_j...@ichf.edu.pl ] . 



Thank you and have a great day, 



Humberto 


[ http://www.icter.pl/ | www.icter.pl ] 
The controller of your personal data is the International Centre for 
Translational Eye Research with its registered office in Warsaw, NIP: 
108002 (ICTER). ICTER will process your data for the purpose of carrying 
out scientific and research activities, providing services and contact with the 
Institute, on the basis of a contract (in connection with the performance of 
the contract or in order to take action on your request before the contract is 
concluded – Article 6, paragraph 1, letter b) of GDPR), the legitimate interest 
of the Institute (Article 6, paragraph 1, letter f) of the GDPR) and legal 
provisions (Article 6, paragraph 1, letter c) of the GDPR) - depending on the 
circumstances. 
You have the right to: request access to your data, receive a copy of it; 
rectify (correct) it; delete it; limit its processing; transfer it; lodge a 
complaint to the supervisory body; withdraw your consent for processing at any 
time (withdrawal of consent does not affect the lawfulness of the processing 
carried out prior to its withdrawal) or to lodge an objection to data 
processing. More information is available on the Institute's website. [ 
https://www.icter.pl/blob/ICTER_GICR.pdf | 
https://www.icter.pl/blob/ICTER_GICR.pdf ] 


From: "Humberto Fernandes"  
To: "ccp4bb"  
Sent: Monday, March 1, 2021 1:55:35 PM 
Subject: [ccp4bb] Postdoctoral position at ICTER in Warsaw, Poland 
(MCBO/34/2021) 





Dear all 



In the Integrated Structural Biology laboratory at The International Center for 
Translational Eye Research (ICTER) in Warsaw, Poland, one postdoctoral position 
is available for highly motivated biologists, biochemists, or structural 
biologists, for 33 months (maximum planned period of contract: 31/12/2023). The 
position involves cloning, protein production, purification, characterization, 
and structural elucidation of proteins from the visual cycle. 



For details and how to apply until 21st March, see: 

[ https://ichf.edu.pl/en/job/mcbo-34-2021-mab-2019-12 | 
https://ichf.edu.pl/en/job/mcbo-34-2021-mab-2019-12 ] 



Feel free to spread this information at your institutes and to interested 
colleagues. And please do not hesitate to contact me if you have any questions. 
To apply, please send the requested documents to [ 
mailto:rekruta...@ichf.edu.pl | rekruta...@ichf.edu.pl ] with the title 
MCBO/34/2021. 



Thank you and have a great day, 



Humberto 


[ http://www.icter.pl/ | www.icter.pl ] 
The controller of your personal data is the International Centre for 
Translational Eye Research with its registered office in Warsaw, NIP: 
108002 (ICTER). ICTER will process your data for the purpose of carrying 
out scientific and research activities, providing services and contact with the 
Institute, on the basis of a contract (in connection with the performance of 
the contract or in order to take action on your request before the contract is 
concluded – Article 6, paragraph 1, letter b) of GDPR), the legitimate interest 
of the Institute (Article 6, paragraph 1, letter f) of the GDPR) and legal 
provisions (Article 6, paragraph 1, letter c) of the GDPR) - depending on the 
circumstances. 
You have the right to: request access to your data, receive a copy of it; 
rectify (correct) it; delete it; limit its processing; transfer it; lodge a 
complaint to the supervisory body; withdraw your consent for processing at any 
time (withdrawal of consent does not affect the lawfulness of the processing 
carried out prior to its withdrawal) or to lodge an objection to data 
processing. More information is available on the Institute's website. [ 
https://www.icter.pl/blob/ICTER_GICR.pdf | 
https://www.icter.pl/blob/ICTER_GICR.pdf ] 




To unsubscribe from the CCP4BB list, click the following link: 
[ https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 | 
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 ] 



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1

This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list 
hosted by www.jiscmail.ac.uk, terms & conditions are available at 
https://www.jiscmail.ac.uk/policyandsecurity/

[ccp4bb] Postdoctoral position at ICTER in Warsaw, Poland (MCBO/34/2021)

2021-03-01 Thread Humberto Fernandes 




Dear all 



In the Integrated Structural Biology laboratory at The International Center for 
Translational Eye Research (ICTER) in Warsaw, Poland, one postdoctoral position 
is available for highly motivated biologists, biochemists, or structural 
biologists, for 33 months (maximum planned period of contract: 31/12/2023). The 
position involves cloning, protein production, purification, characterization, 
and structural elucidation of proteins from the visual cycle. 



For details and how to apply until 21st March, see: 

[ https://ichf.edu.pl/en/job/mcbo-34-2021-mab-2019-12 | 
https://ichf.edu.pl/en/job/mcbo-34-2021-mab-2019-12 ] 



Feel free to spread this information at your institutes and to interested 
colleagues. And please do not hesitate to contact me if you have any questions. 
To apply, please send the requested documents to [ 
mailto:rekruta...@ichf.edu.pl | rekruta...@ichf.edu.pl ] with the title 
MCBO/34/2021. 



Thank you and have a great day, 



Humberto 


[ http://www.icter.pl/ | www.icter.pl ] 
The controller of your personal data is the International Centre for 
Translational Eye Research with its registered office in Warsaw, NIP: 
108002 (ICTER). ICTER will process your data for the purpose of carrying 
out scientific and research activities, providing services and contact with the 
Institute, on the basis of a contract (in connection with the performance of 
the contract or in order to take action on your request before the contract is 
concluded – Article 6, paragraph 1, letter b) of GDPR), the legitimate interest 
of the Institute (Article 6, paragraph 1, letter f) of the GDPR) and legal 
provisions (Article 6, paragraph 1, letter c) of the GDPR) - depending on the 
circumstances. 
You have the right to: request access to your data, receive a copy of it; 
rectify (correct) it; delete it; limit its processing; transfer it; lodge a 
complaint to the supervisory body; withdraw your consent for processing at any 
time (withdrawal of consent does not affect the lawfulness of the processing 
carried out prior to its withdrawal) or to lodge an objection to data 
processing. More information is available on the Institute's website. [ 
https://www.icter.pl/blob/ICTER_GICR.pdf | 
https://www.icter.pl/blob/ICTER_GICR.pdf ] 



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1

This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list 
hosted by www.jiscmail.ac.uk, terms & conditions are available at 
https://www.jiscmail.ac.uk/policyandsecurity/

[ccp4bb] Post-Doctoral position in Porto, Portugal - Reminder

2021-03-01 Thread Pedro Pereira 



We are looking for a highly motivated post-doc to join the 
Macromolecular Structure group of i3S - Instituto de Investigação e 
Inovação em Saúde (https://www.i3s.up.pt/research-group?x=113) in Porto, 
Portugal. The position, funded for 3 years, is expected to start in 
April 2021.


Building on our recent work (1-5), the project aims to develop direct 
anticoagulants against alternative targets in the blood coagulation 
cascade that have not been clinically exploited to date or represent a 
completely unexplored mechanism of intervention. The successful 
candidate will investigate the inhibition potency and anticoagulant 
activities /in vitro/ of potential inhibitors screened by Random 
nonstandard Peptide Integrated Discovery (RaPID). The candidate will 
also study the molecular determinants of inhibition, using X-ray 
crystallography, and perform SAR studies. Finally, the efficacy of lead 
compounds will be investigated /in vivo/.


The ideal candidate should hold a PhD in Biochemistry, Structural 
Biology or in a related field, with a good publication record (at least 
2 publications as first author in peer-reviewed journals).


Informal enquiries can be addressed to Jorge Ripoll-Rozada 
(jorge.roz...@ibmc.up.pt ) or Pedro J.B. 
Pereira (ppere...@ibmc.up.pt) .


Please note that applications will be considered ONLY if submitted 
(together with all accompanying documentation) before 2021/03/07, using 
the online tool at https://www.i3s.up.pt/job-opportunities.php#positions 
(Position reference: Researcher/FCT_PROJ2020/i3S/1202/2021).


Direct application link: 
https://dozer.i3s.up.pt/applicationmanagement/#/addapplications/ResearcherFCT_PROJ2020i3S12022021


Further information: 
https://dozer.i3s.up.pt:8443/fileupload/downloadfile/viewpdfnewtab/50f244dcc6f8b1ecb55beb7ceff2a57 
(in Portuguese) or 
https://dozer.i3s.up.pt:8443/fileupload/downloadfile/viewpdfnewtab/33258f72eae84e385ca4ea1abeb764 
(in English).


1- Thompson, R.E.; Liu, X.; Ripoll-Rozada, J.; Alonso-García, N.; 
Parker, B.L.; Pereira, P.J.B.; Payne, R.J. (2017) Tyrosine sulfation 
modulates activity of tick-derived thrombin inhibitors. /Nature 
Chemistry/ *9*, 909-917. DOI: 10.1038/nchem.2744


2 - Watson, E.; Liu, X.; Thompson, R.; Ripoll-Rozada, J.; Wu, M.; Alwis, 
I.; Gori, A.; Loh, C.-T.; Parker, B.; Otting, G.; Jackson, S.; Pereira, 
P.J.B.; Payne, R. (2018) Mosquito-derived anophelin sulfoproteins are 
potent anti-thrombotics. /ACS Central Science/ *4*, 468-476. DOI: 
10.1021/acscentsci.7b00612


3 - Watson, E.E.; Ripoll-Rozada, J.; Lee, A.C.; Wu. M.C.L.; Franck, C.; 
Pasch, T.; Premdjee, B.; Sayers, J.; Pinto, M.F.; Martins, P.M.; 
Jackson, S.P.; Pereira, P.J.B.; Payne, R.J. (2019) Rapid Assembly and 
Profiling of an Anticoagulant Sulfoprotein Library. /Proceedings of the 
National Academy of Sciences of the USA/ *116*, 13873-13878. DOI: 
10.1073/pnas.1905177116


4 - Calisto, B.M.; Ripoll-Rozada, J.; Dowman, L.J.; Franck, C.; Agten, 
S.M.; Parker, B.L.; Veloso, R.C.; Vale, N.; Gomes, P.; de Sanctis, D.; 
Payne, R.J.; Pereira, P.J.B. (2021) Sulfotyrosine-Mediated Recognition 
of Human Thrombin by a Tsetse Fly Anticoagulant Mimics Physiological 
Substrates. /Cell Chemical Biology/ *28*, 26-33. DOI: 
10.1016/j.chembiol.2020.10.002


5 - Agten, S.M.; Watson, E.E.; Ripoll-Rozada, J.; Dowman, L.J.; Wu, M.; 
Alwis, I.; Jackson, S.; Pereira, P.J.B.; Payne, R.J. (2021) Potent 
trivalent inhibitors of thrombin through hybridization of salivary 
sulfopeptides from hematophagous arthropods. /Angewandte Chemie 
International Edition/, in press. DOI: 10.1002/anie.202015127


--
Pedro J. B. Pereira, PhD
IBMC - Biomolecular Structure Group
i3S - Macromolecular Structure Group
Rua Alfredo Allen 208
4200-135 Porto
Portugal
Tel.  +351 226 074 954
E-mail:ppere...@ibmc.up.pt

--
Pedro J. B. Pereira, PhD
IBMC - Biomolecular Structure Group
i3S - Macromolecular Structure Group
Rua Alfredo Allen 208
4200-135 Porto
Portugal
Tel.  +351 226 074 954
E-mail:ppere...@ibmc.up.pt

--
Pedro J. B. Pereira, PhD
IBMC - Biomolecular Structure Group
i3S - Macromolecular Structure Group
Rua Alfredo Allen 208
4200-135 Porto
Portugal
Tel.  +351 226 074 954
E-mail: ppere...@ibmc.up.pt




To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1

This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list 
hosted by www.jiscmail.ac.uk, terms & conditions are available at 
https://www.jiscmail.ac.uk/policyandsecurity/