[ccp4bb] Senior Research Scientist position (Membrane Protein Biochemistry and Structural Biology)

2021-10-01 Thread Juan Du 
A Senior Research Scientist position (Membrane Protein Biochemistry and 
Structural Biology) is available in the laboratories of Drs. Juan Du and Wei Lü 
at Van Andel Institute. The ideal candidate will be involved in exciting and 
highly integrated multi-disciplinary research projects understanding the 
molecular mechanism and pharmacology of ion channels.

The Du Lab and the Lü Lab (dululabs.com) are interested in understanding the 
molecular mechanisms of how the body perceives sensory information (e.g. taste, 
smell, vision, and temperature), transmits signals to the brain, and generates 
responses. We focus on ion channels involved in the basic senses. We employ a 
range of structural and biophysical approaches, including single-particle 
cryo-EM, patch-clamp electrophysiology, and other biochemical methods. 

Qualifications
The candidate should hold a PhD degree with 3+ years’ experience in membrane 
protein biochemistry and/or structural biology. The candidate must have a 
proven track record in cloning, mammalian cell culture, membrane protein 
expression and purification. Experience in structural biology (cryo-EM or x-ray 
crystallography) is a plus but not required. 

How to Apply
•   Online Application: 
•   CV 
•   Cover Letter 
Send the CV, Cover Letter and contact information of three referees to Juan Du 
(juan...@vai.org) or Wei Lü, wei...@vai.org 



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[ccp4bb] Rigaku X-ray diffractometer open for bidding

2021-10-01 Thread Palm, Gottfried 
Dear all, 

  our previous Rigaku X-ray diffractometer is being offered by the
VEBEG (auctions of used stuff from federal institutions in Germany)
for the highest bid. It is only in German, but open to all bidders. 

https://www.vebeg.de/de/verkauf/suchen.htm?DO_SUCHE=1_MATGRUPPE=1170_AUS=2142260_LOS=2

The machine as a whole is not functioning. It doesn't power up and we
don't know, which part(s) are responsible. We expect problems in (one
of) the generator boards. Several parts should work, though:

anode: one in the machine, which worked until the end of operation; a
second one, which can be refurbished
osmic mirror
goniometer AFC12
detector: Saturn 92 CCD camera
Cryotiger (cooling the CCD camera to -30°C)
control unit for the CCD camera and goniometer, supplies the data to
the frame grabber via glas fiber cable
TMP, Part No 906116, Rebuilt, TMP, Varian, V81
TMP adapter, Part No 902123, Adapter, TMP-TV81
TRAFO for the high voltage generator

Possibly defunct parts: 
TMP driver, Part No 1014563, Driver, TMP, PCB, Agilent, V81 (this
board could be one of the parts which lead to failure of the system)
2 computers (frame grabber and data collection control) (as a set they
don't boot properly anymore)

Not part of the offer:
Cryosystem
Crystal camera
Oil pump
Chiller for anode

Feel free to get in contact with us, jens.hop...@uni-greifswald.de,
michael.lamm...@uni-greifswald.de, p...@uni-greifswald.de, we will be
back in office on Oct 11th and might not answer the emails before. 
Greetings
  Gottfried 

Gottfried Palm
Synthetic and Structural Biochemistry
Institute for Biochemistry 
University of Greifswald
Felix-Hausdorff-Str. 4
17489 Greifswald
Germany



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[ccp4bb] Postdoc position in peptide-based PROTACs

2021-10-01 Thread Marcus Hartmann 
Dear BB,

we have a Postdoc opening in our group at the Interfaculty Institute of 
Biochemistry and the Max Planck Institute for Developmental Biology in 
Tübingen, Germany.

We are looking for someone who can't wait to develop peptide-based PROTACs as 
next-generation therapeutics with us. The candidate does not need to be an 
expert in crystallography but have a solid understanding of structural biology 
in general.

Please find more details here:
http://eb.mpg.de/fileadmin/uploads/PostDoc_peptidic_PROTACs.pdf

Best wishes,
Marcus


--
Dr. Marcus Hartmann
Max Planck Institute for Developmental Biology
Max-Planck-Ring 5, 72076 Tübingen, Germany. Phone: +49 (0)7071 601 323
http://www.eb.mpg.de/protein-evolution/marcus-hartmann/



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[ccp4bb] XChem proposals: NEXT WEDS (Oct 6)

2021-10-01 Thread Frank von Delft 

Hello all -

Reminder of the deadline *NEXT WEEK WEDNESDAY Oct 6 (5pm UK)* to apply 
for access to Diamond's XChem facility for April-Oct 2022.


(Same deadline as other Diamond access, in case you're wondering - it's 
2x per year.)


NOTE:  Diamond greatly welcomes BAG proposals, it makes everybody's 
lives massively simpler.
So if you are aware of colleagues that are close (whether 
geographically, organisationally or even scientifically), that also want 
to do XChem, please do reach out to them, and read the proposal 
instructions carefully.



The XChem webpage is here:
https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/ 



How to apply is here:
https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/XChem-Applications.html 




Looking forward to your applications!
Frank


Prof. Frank von Delft
Professor for Structural Chemical Biology
Principal Beamline Scientist: I04-1/XChem
Diamond Light Source
+44 1235 778997 (o)
+44 7471 026103 (m)




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[ccp4bb] LAST CHANCE TO APPLY: DLS/CCP4 data analysis workshop 2021

2021-10-01 Thread David Waterman 
Hi folks,

The application deadline for this year's online DLS/CCP4 workshop is today,
17:00 UK time. If you haven't yet applied but want a chance to come you
still have a few hours to submit your application!

Cheers
-- David


On Fri, 24 Sept 2021 at 13:23, David Waterman  wrote:

> Hi folks,
>
> A reminder: there is one week left to apply for this year's DLS/CCP4
> workshop. Please see below for details.
>
> Best wishes
> -- David
>
>
> On Tue, 14 Sept 2021 at 16:12, David Waterman 
> wrote:
>
>> We are pleased to announce that the 8th joint Diamond-CCP4 Workshop on MX
>> data collection and structure solution is now open for applications.
>>
>> Bringing together leading experts in the field of MX to teach best
>> practice in data collection and analysis, this course is aimed at PhD
>> students, postdocs and early career scientists who have a focus on
>> structural biology.
>>
>> The workshop will take place online via Zoom over the course of two full
>> weeks, plus a preparation day in advance of the workshop. It is essential
>> that applicants commit to attending the workshop in its entirety. Please
>> note below the workshop days and timings involved:
>>
>> - Preparation day: Tuesday 23 November 2021
>> - Week 1: Monday 29 November to Friday 3 December 2021
>> - Week 2: Monday 6 December to Friday 10 December 2021
>> - The days will generally begin at 08:45 and will finish at 17:15 (UK
>> time)
>>
>> There is no fee to attend this online workshop, however attendance will
>> be subject to an application process and a letter of support from the
>> attendee's supervisor will be required. Both the application form and
>> supervisor's letter of support will need to be submitted by 17:00 (UK time)
>> on Friday 1 October 2021 (though see disclaimer below).
>>
>> Some prior experience of crystallography and data collection is expected,
>> and those who already have an interesting project (crystals and possibly
>> previously collected datasets) will be given priority in selection.
>>
>> - The course homepage: https://www.ccp4.ac.uk/schools/DLS-2021/
>> - Apply at the Diamond website:
>> https://www.diamond.ac.uk/Home/Events/2021/Diamond-CCP4-Data-Collection-and-Structure-Solution-Workshop-2021.html
>>
>> *Disclaimer* Depending on the number of submissions we receive, we may
>> need to close applications earlier than the stated deadline to allow the
>> organisers time to process them. Applicants are therefore encouraged to
>> apply as soon as possible with all the required details requested,
>> including the letter of support. Incomplete applications will not be
>> processed.
>>
>> -- David (on behalf of the organisers)
>>
>



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