[ccp4bb] Postdoc position at the National Cancer Institute in computational structural biology

[Philippe Youkharibache]

A A post-doctoral position is available in the Cancer Data Science Lab in 
computational structural biology to study the structure and function of cell 
surface proteins and engineer optimized chimeric antigen receptor constructs, 
integrating structural, biophysical and biological constraints.  It is a key 
position in an interdisciplinary project bridging structural biology (cryoEM, 
NMR, Xray), computational biology, cell biology and clinical trials.

https://ccr.cancer.gov/careers/post-doctoral-fellow-molecular-modeling-computational-biology/25047
 
 
Chimeric Antigen Receptors (CAR) are the backbone of CAR-T cell therapies 
(https://www.cancer.gov/about-cancer/treatment/research/car-t-cells). They are 
the focus of over 700 clinical studies being conducted worldwide.  Many teams 
throughout the world are focusing on the optimization of CAR-Ts for the 
treatment of patients with relapsed/refractory cancers but the vast majority of 
studies are performed by an empirical trial and error approach.  This project 
brings together expertise in CAR-T cell biology, structural biology, 
computational structural modeling and machine learning to develop a rational 
design approach.
 
Qualifications:
The candidates should hold a Ph.D. degree, have at least one first author 
publication and have a strong knowledge of protein structure.  Experience in 
protein modeling, molecular dynamics simulations (Amber, NAMD, CHARMM, Gromacs 
etc.), and biophysics methods is needed. Artificial Intelligence (Machine 
learning) experience and/or software development experience are a plus but not 
required.
 
To Apply:
Interested individuals should send a cover letter outlining research interests 
and long-term goals, CV and the names of three references to:
Philippe Youkharibache, Ph.D. philippe.youkhariba...@nih.gov
 
 
The NIH is dedicated to building a diverse community in its training and 
employment programs and encourages the application and nomination of qualified 
women, minorities, and individuals with disabilities. DHHS and NIH are Equal 
Opportunity Employers.



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[ccp4bb] CBMS Workbench - Structural Biology June 6-8 2022

[Stojanoff, Vivian]

Dear Colleagues

We'd like to bring to your attention that registration is open for the CBMS 
Structural Biology  workbenches scheduled June 6 through 8. Participants can 
choose between Solution Scattering and MX or attend both. Intended as an 
information and training for new members and refresher for those experienced 
members the Workbench invites participants to send their samples and measure 
them during the workbenches.

Register for free:

https://www.bnl.gov/cbmsworkbench/

Registration deadlines:

May 23, 2022 if  sending samples
June 1st , 2022 if  attending lectures, tutorials and demonstrations

Those sending samples should also contact Vivian Stojanoff (stoja...@bnl.gov) 
and James Byrnes (jbyr...@bnl.gov) or phone (631) 344 8375;  for more 
information.

Kind regards,

Vivian

==

Vivian Stojanoff, PhD

Education, Training, Outreach

User Program

p: 1(631) 344 8375

e: nsls.lifescien...@gmail.com 

https://www.bnl.gov/nsls2/lifesciences/


Address:

Center for Biomolecular Structure

National Synchrotron Light Source II

Building 745

Brookhaven National Laboratory

Upton NY 11973


*Supporting Grants:*CBMS is supported by NIH-NIGMS #P30GM133893, and by the 
DOE-BER #KP1605010. Any work performed at NSLS-II is supported by DOE-BESunder 
contract # DE-SC0012704.




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[ccp4bb] Postdoctoral position at the National Institutes of Health in Bethesda, Maryland

[Ville Uski]

On behalf of Dr Marius Clore:

A postdoctoral position is available in the lab of Marius Clore in the
Laboratory of Chemical Physics at the National Institutes of Health in
Bethesda, Maryland.

Particular emphasis within the lab concerns the study of excited states
involved in molecular recognition and fibril assembly using
state-of-the-art NMR and EPR spectroscopy.  Current focus is on the
study of the mechanism of aggregation of huntingtin and the study of
various chaperones with anti-aggregation and disaggregation properties.
Additional work is also being carried out using time resolved DEER EPR
and solid state NMR in combination with sub-millisecond freeze quenching
to probe complex transient kinetic pathways involved in molecular
recognition.

Some recent papers are listed below.

Applicants should e-mail their interest directly to
mari...@intra.niddk.nih.gov include their CV/bibliography and the names
of two references.

Recent papers from the lab of Marius Clore:

Kotler, S.A, Tugarinov, V., Schmidt, T., Ceccon, A., Libich, D.S.,
Ghirlando, R., Schwieters, C.D. and Clore, G.M. (2019) Probing initial
transient oligomerization events facilitating Huntingtin fibril
nucleation at atomic resolution by relaxation-based NMR. Proc. Natl.
Acad. Sci. U. S. A. 116, 3562-3571.

Karamanos, T.K., Tugarinov, V. & Clore, G.M. (2019) Unraveling the
structure and dynamics of the human DNAJB6b chaperone by NMR reveals
insights into Hsp40-mediated proteostasis. Proc. Natl. Acad. Sci. U.S.A.
116, 21529-21538.

Ceccon, A., Tugarinov, V., Ghirlando, R. & Clore, G.M. (2020) Abrogation
of pre-nucleation, transient oligomerization of the Huntingtin exon-1
protein by human profilin-I. Proc. Natl. Acad. Sci. U.S.A. 117,
5844-5852.

Ceccon, A., Tugarinov, V. & Clore, G.M. (2021) Quantitative exchange
NMR-based analysis of Huntingtin-SH3 interactions suggests an allosteric
mechanism of inhibition of Huntingtin Aggregation. J. Am. Chem. Soc.
143, 9672-9681.

Walti, M.A., Kotler, S.A. & Clore, G.M. (2021)  Probing the interacttion
of huntingtin exon-1 polypeptides with the chaperonin nanomachine GroEL.
ChemBioChem 22, 1985-1991

Okuno, Y., Yoo, J., Schwieters, C.D., Best, R.B., Chung, H.S. & Clore,
G.M. (2021) Atomic view of cosolute-induced protein denaturation probed
by NMR solvent paramagnetic relaxation enhancement. Proc. Natl. Acad.
Sci. U.S.A. 118, e211202118

Schmidt, T., Jeon, J., Yau, W.-M., Schwiters, C.D., Tycko, R. & Clore,
G.M. (2022) Time-resolved DEER EPR and solid-state NMR afford kinetic
and structural elucidation of substrate binding to Ca2+-ligated
calmodulin. Proc. Natl. Acad. Sci. U.S.A. 119, e2122308119.

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[ccp4bb] Position available at Biotech Desk Pvt. Ltd, India – a unique opportunity for a structural biology enthusiast

[Patrick Shaw Stewart]

Posted on behalf of the Biotech Desk

Biotech Desk, located at Hyderabad, India is looking to recruit a
crystallization specialist for maintenance and installations of the Oryx
robots for protein crystallization. The person would also be in charge of
their lab services involving protein crystallization using client proteins
as a fee for service. Different constructs of the protein will be
expressed, purified and crystallized including both screening of crystal
forming conditions and optimization. Candidates who have completed their
post-graduation in Life sciences, Biophysics or related fields may apply.
The job is a right mix of bench work and customer interaction. Previous
sales experience is helpful but not essential. Interested candidates may
send their resumes to Ms. Kavitha at ad...@biotechdesk.com. Remuneration
depends upon the qualification of the person applying.



-- 
 patr...@douglas.co.ukDouglas Instruments Ltd.
 Douglas House, East Garston, Hungerford, Berkshire, RG17 7HD, UK
 Directors: Patrick Shaw Stewart, Peter Baldock, Stefan Kolek

 http://www.douglas.co.uk
 Tel: 44 (0) 148-864-9090US toll-free 1-877-225-2034
 Regd. England 2177994, VAT Reg. GB 480 7371 36



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[ccp4bb] postdoc position in mitochondrial structural and cellular biology - Center for Protein Research, University of Copenhagen (Kummer)

[Eva Kummer]

Dear all,


we are looking for an excellent, highly motivated and self-organized 
postdoctoral candidate to join our young group at the Center for Protein 
Research at the University of Copenhagen. The postdoc project aims to 
investigate how mitochondria maintain the integrity of their genetic 
information using molecular cell biology and single particle cryo-EM. We are 
specifically looking for someone with significant experience in mammalian cell 
culture techniques, purification of recombinantly expressed proteins and strong 
proficiency in cryo-electron microscopy (single particle or cryo-ET). At CPR, 
you will join a collaborative and international environment.


The position is available from 01 October 2022 or as soon as possible 
thereafter.


For more information, please visit: 
https://employment.ku.dk/faculty/?show=156551

The Center for Protein Research hosts research groups of different disciplines 
ranging from systems biology, proteomics, and chemical biology, to disease 
biology. The primary methodological approaches of our laboratory are single 
particle cryo-electron microscopy and protein and RNA biochemistry. Our group 
profits from generous funding by an NNF-CPR core grant and a Hallas Møller 
Emerging Investigator grant from the Novo Nordisk Foundation. We have access to 
a fully equipped mammalian and insect cell culture facility in house and 
state-of-the-art fluorescence and electron microscopy instrumentation at CPR 
and CFIM (Core Facility for Integrated Microscopy at the University of 
Copenhagen). In addition, CPR entertains several core facilities including 
protein production, crystallography, biophysics, high performance computing, 
mass spectrometry, and genomics.

Please get in touch for informal inquiries via eva.kum...@cpr.ku.dk

Application deadline is 14 June 2022. Application will have to be submitted via 
the online application portal of Copenhagen University.

I am looking forward to be hearing from you.
With best wishes,
Eva


Eva Kummer
Group Leader / Associate Professor

University of Copenhagen
Novo Nordisk Foundation Center for Protein Research
Protein Structure and Function Program
Blegdamsvej 3B
2200 København N




https://www.cpr.ku.dk/research/protein-structure-function-program/kummer/





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