[ccp4bb] PhD in SPA cryoEM

[Francesca Coscia]

Do you like molecular mechanisms, #cryoem and want to solve outstanding 
problems in thyroid medicine? Join my group at @humantechnopole for a 4 years 
PhD in #structuralbiology! Contact me by email for further details on the 
project Funded by ERC

https://www.semm.it/content/structural-and-functional-characterization-thyroid-trafficking-factors-coscia



Francesca Coscia
Research Group Leader
Coscia Group,
Structural Biology Research Centre
Human Technopole
Palazzo Italia
Viale Rita Levi Montalcini, 1
20157 Milan, Italy
M. +39 342 199 5945
E. francesca.cos...@fht.org
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[ccp4bb] Postdoctoral Position in CNS antibody-ion channel mechanisms and design

[Paul Miller]

Applications are invited for a postdoctoral researcher position in the 
laboratory of Dr Paul Miller at the Department of Pharmacology, University of 
Cambridge, beginning from around October 2022.

The project will focus on studying the molecular basis of antibody modulation 
of ion channel function and applying structure-guided approaches to engineer 
new research tools. This is vital to define channel subtype contributions to 
CNS physiology and disease and to discover new therapeutic modalities. This is 
a great opportunity to gain experience in one or more aspects of handling 
challenging membrane proteins, structure-guided antibody engineering, and 
cryo-EM, ideal for follow-on academic and biotechnology careers. The lab 
utilises mammalian cell protein expression systems, membrane protein 
purification, and cryo-EM via Arctica and Krios microscopes with K2/K3 direct 
detectors, and also has manual and automated electrophysiology equipment,. More 
information about the laboratory is available at 
https://www.phar.cam.ac.uk/research/miller.

The applicant will be about to obtain a PhD or have obtained a PhD within the 
last 3 years. Experience in molecular biology, protein production, purification 
and structural biology (X-ray crystallography or cryo-EM) is required. You must 
be a careful and methodical worker, paying attention to accuracy, be able to 
take responsibility and interact as part of a tightly knit team, and be willing 
to work in a collaborative environment. You should be self-motivated and able 
to organise, perform and analyse experiments with minimal instruction.

A recent relevant publication from the lab is:
Kasaragod VB, Mortensen M, Hardwick SW, Wahid AA, Dorovykh V, Chirgadze DY, 
Smart TG, Miller PS.
Mechanisms of inhibition and activation of extrasynaptic alpha-beta GABA-A 
receptors.
Nature. 2022 Feb;602(7897):529-533. PMID: 35140402

Application Closing date: 15th July 2022
Project start date: Approximately 1st October 2022
For more details and to apply: https://www.https://www.jobs.cam.ac.uk/job/35285/
Informal enquiries about the position can be made to Dr Paul Miller 
(pm...@cam.ac.uk)
For enquiries about the online application process please contact Debbie 
Stanley, phar...@lists.cam.ac.uk


Paul Miller, PhD
University Lecturer in Pharmacology
Department of Pharmacology
University of Cambridge
Tennis Court Road
Cambridge
CB2 1PD
+44 1223 761267
https://www.phar.cam.ac.uk/research/miller



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[ccp4bb] Recommendations for liquid handler

[M. Joanne Lemieux]

Hi all

We are looking to purchase an automated liquid handler suitable for protein
crystallography and enzymatic assays. Any recommendations from those using
one?

Joanne

**
M. Joanne Lemieux, Ph.D.
Professor, Department of Biochemistry
Director, Membrane Protein Disease Research Group
Member of LKSIOV, WCHRI, NMHI, CRINA, GlycoNet
College of Health Sciences
Faculty of Medicine & Dentistry
University of Alberta
Medical Sciences Bldg.
Office 4-53
Lab4-51
University of Alberta
Edmonton AB, T6G 2H7

office phone: 780-492-3586
lab phone:780-492-3465
fax: 780-492-0886

Lab web pages:
*https://lemieuxlab.biochem.ualberta.ca/
*
http://www2.biochem.ualberta.ca/LemieuxLab

Membrane Protein Disease Research Group:
http://www.mpdrg.com


The University of Alberta is located in ᐊᒥᐢᑿᒌᐚᐢᑲᐦᐃᑲᐣ (Amiskwacîwâskahikan) on
Treaty 6 territory, the territory of the Papaschase, and the homeland
of the Métis
Nation.

CONFIDENTIALITY WARNING
This communication is intended for the use of the recipient to which it is
addressed, and may contain confidential, personal, and/or privileged
information. Please contact me immediately if you are not the intended
recipient of this communication, and do not copy, distribute, or take
action relying on it. Any communication received in error, or subsequent
reply, should be deleted or destroyed.



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[ccp4bb] Join our Experts in a Discussion of TEM for Biological Applications

[Nylese, Tara]

Dear Community,

We're pleased to have an excellent panel for this month's Ask the Experts Web 
session including Dr. Dennis Thomas from Cold Spring Laboratory, Dr. Davide 
Demurtas from the Swiss Federal Institute of Technology, EPFL , and Dr. 
Aleksandr Mironov from the University of Manchester. This group will share 
their broad experiences for characterization of nanoparticles as well as 
cellular ultrastructure in three different multidisciplinary electron 
microscopy facilities.

If you are a biochemist, molecular biologist, or cell biologist, then you won't 
want to miss this chance to learn from our expert panel.

Join us on Tuesday, June 21, 2022 at 8 a.m. PDT, 11 a.m. EDT, 5 p.m. CEST.

Please click here to register 
now

Best Regards,
Tara Nylese
Market Development Manager, Americas
Life Sciences
Materials & Structural Analysis
Thermo Fisher Scientific
tara.nyl...@thermofisher.com
(845)664-8445

[cid:image001.jpg@01D88477.EA54F2C0]




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[ccp4bb] Scientific Data Curator position (PDB and EMDB)

[Deborah Harrus]

Dear all,

We are looking to recruit an expert structural biologist to join the 
PDBe curation team on the Wellcome Genome Campus near Cambridge. The 
work involves annotating preliminary PDB and EMDB submissions and 
extracting relevant biological information. The closing date for the 
post is 17th July 2022. For more information on the position, please visit:


https://www.embl.org/jobs/position/EBI02041

Kind Regards,
Deborah

--
---
Deborah Harrus, Ph.D.
Lead Annotator
PDBe - Protein Data Bank in Europe

European Bioinformatics Institute (EMBL-EBI)
European Molecular Biology Laboratory
Wellcome Trust Genome Campus
Hinxton
Cambridge CB10 1SD UK

http://www.PDBe.org
---



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