[ccp4bb] 2-year postdoctoral position available - Structural Microbiology, Institut Pasteur

[Marco BELLINZONI]

Dear all,
A 2-year post-doc position is currently available at the Structural 
Microbiology Unit, located at the Institut Pasteur in Paris.
Our team has been working on the molecular mechanisms underlying the metabolic 
plasticity of Actinobacteria, with a special emphasis on the signaling pathways 
involved (for an overview of the topic and our recent work, please see Wagner 
et al., Sci. Signal., 2019; Bellinzoni et al., Genes Immun., 2019). The 
postdoctoral fellow will join an active and multidisciplinary environment, 
working on Corynebacterium glutamicum enzymes and protein complexes involved in 
central metabolism, and applying an integrative structural biology approach in 
which cryo-EM plays a key role. The project is part of a French-German 
initiative funded by the respective national research agencies (ANR and DFG), 
and will be performed in collaboration with the groups led by Profs. Michael 
Bott (Forschungszentrum Jülich) and Bernhard Eikmanns (University of Ulm).
The Structural Microbiology Unit is fully equipped for microbiology and protein 
biochemistry work, and has a well-established network of collaborations. In 
addition, the institute’s campus provides a vibrant scientific life as well as 
access to excellent core facilities. A full range of state-of-the-art equipment 
for structural biology and biophysics is available, including a Titan Krios and 
two Glacios microscopes currently undergoing installation. The unit has also 
regular access to synchrotron beamlines for X-ray crystallography and SAXS.
The position is open from October 2019, although the starting date may be 
arranged. The ideal candidate is an enthusiastic PhD with a good publication 
record and a solid background in protein biochemistry and biophysics. Good team 
spirit and presentation skills in English are essential; experience in dealing 
with large macromolecular complexes, protein-protein interaction studies and/or 
cryo-EM would be an asset. Interested candidates should provide a full CV with 
a summary of previous research experience, a brief statement of interest on the 
position and contacts of a couple of referees to marco (dot) bellinzoni (at) 
pasteur (dot) fr. Please send applications or informal enquiries no later than 
June 5.
Best regards,
Marco

===
Marco Bellinzoni
Unité de Microbiologie Structurale
Institut Pasteur
25, rue du Dr. Roux
75724 Paris Cedex 15
France
Tel: +33 (0)1 45688608
Fax: +33 (0)1 45688604
===






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[ccp4bb] Postdoctoral position - Structural Microbiology, Institut Pasteur

[Marco Bellinzoni]

Dear all,

a 2-year postdoctoral position funded by the ANR (the French National 
Agency for Research) is available at the Structural Microbiology Unit at 
the Institut Pasteur in Paris.


Our team has been working on the regulation of central metabolism in 
Mycobacteria, with particular emphasis on the role of GarA, an 
FHA-domain protein that turned out to act as a regulator of a few 
central metabolic enzymes - a control level that seems to be unique to 
the Actinobacteria phylum. The project in which the postdoctoral fellow 
will be enrolled aims at isolating from the source organism (top-down 
approach) and/or reconstructing in vitro (bottom-up) a central metabolic 
'supercomplex' from Corynebacterium glutamicum, and possibly the 
non-pathogenic Mycobacterium smegmatis, in order to characterize it by 
an integrated structural biology approach (X-ray crystallography, SAXS, 
cryo-EM).


The lab is fully equipped for recombinant protein expression and 
purification and interacts closely with a number of facilities (e.g. 
crystallography, macromolecular biophysics, microscopy) providing access 
to state-of-the-art equipment and located a few steps within the 
institute campus. Regular access (on a monthly basis) is also available 
to MX and SAXS beamlines, both at the Soleil and ESRF synchrotrons.


The ideal candidate is an enthusiastic and self-motivated PhD with a 
strong background in protein biochemistry, and experience in dealing 
with multi-subunit macromolecular complexes. Familiarity with SAXS 
and/or cryo-EM would be an asset. The position will be available from 
March 2014, although the starting date may be arranged.


If interested, please send a CV with your publication list and detailed 
research experience (including contacts of a couple of referees) by 
*November 15* to marco.bellinzoni at pasteur.fr.


Best,
Marco

--

==
Marco Bellinzoni
Unité de Microbiologie Structurale
Institut Pasteur
25, rue du Dr. Roux
75724 Paris Cedex 15
France
Tel. +33 (0)1 45688608
Fax. +33 (0)1 45688604
==