[ccp4bb] Job Posting request for Johnson Johnson
Janssen Research and Development, L.L.C., a member of Johnson and Johnson's Family of Companies, is recruiting for a Post-Doctoral Scientist, Biologics Research in Spring House, PA. This Post-Doctoral position will be a two year assignment. At the Janssen Pharmaceutical Companies of Johnson Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. Janssen Research Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit http://www.JanssenRnD.com http://www.janssenrnd.com/ for more information. We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it. Janssen RD, LLC is looking for a self-motivated post-doctoral scientist to study mechanisms of action for biologic therapeutics and their targets. The successful candidate will apply structural biology approaches to biologics and biologic/target complexes. This position will give the candidate exposure to many aspects of biologic discovery and development. The candidate is expected to publish the results of his/her project(s). Job Requirements Candidates must have a PhD in Biochemistry, Biophysics or Structural biology with strong skills in X-ray crystallography is required. Additional skills in SAXS or EM, protein expression and purification are preferred. This position will give the candidate exposure to many aspects of biologic discovery and development. Programming C++ or UNIX Shell Scripting is a plus. *BE VITAL in your career; be seen for the talent you bring to your work. Explore opportunities within the Johnson Johnson Family of Companies.* Apply Here: http://www.Click2Apply.net/fc3m9w5
[ccp4bb] Job Posting Request
*Merck* is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for all of us. Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career. This exciting position within Merck's Structural Chemistry group will support drug lead discovery and optimization through the determination of the X-ray structures of therapeutically important proteins. The successful candidate will perform crystallization, crystal optimization, and structure determination of protein-ligand complexes and will work in collaboration with medicinal and computational chemists. The successful candidate will also work closely with molecular biologists and protein biochemists and will have access to automated cloning, expression, and crystallization technologies. *Sr. Scientist, Chemistry West Point, PA Job # CHE003955* Productive and collaborative interactions with other members of the global, cross-functional department are a must. Cooperative and collaborative use of internal expertise will be essential to success. The position requires active interaction with the scientific community to continually improve scientific understanding, including presentations at national or international meetings. *Qualifications:* - PhD degree with 2- 3 years postdoctoral training in membrane protein crystallography. - Demonstrated capability to design and execute X-ray crystallographic structure determination using all modern techniques, including molecular replacement and experimental phasing. - Demonstrated potential to develop project management skills and identify/develop new areas of scientific expertise in protein crystallography. - Excellent communication skills (written, presentation, and oral) that enhance team-based progress is required. Application of those skills both within and outside the department to ensure the maximum understanding of program status for therapeutic area project teams and management is required. - Ability to work effectively within timelines. - Ability to prepare peer-reviewed publications. PREFERRED SKILLS: - State-of-the-art knowledge of GPCR structural biology techniques including all aspects of GPCR construct design, expression, solubilization, purification, crystallization screening/optimization (including LCP and LCP-FRAP), and structure determination/analysis a significant plus. - Experience in the application of biophysical and functional characterization methods (e.g., protein NMR, Biacore, Thermofluor, ligand binding and receptor modality) to guide protein construct optimization for crystallography is a plus. Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. To be considered for this position, please visit: http://jobs.merck.com/job/West-Point-Sr_-Scientist%2C-GSC%2C-Chemistry-Job-PA-19486/29518900/ Merck is an equal opportunity employer, M/F/D/V - proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard Reserves - We value your past and present service.
[ccp4bb] Job Posting for MERCK COMPANY INC.
*Sr. Scientist, Chemistry* *Merck* is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for all of us. Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career. This exciting position within Merck's Structural Chemistry group will support drug lead discovery and optimization through the determination of the X-ray structures of therapeutically important proteins. The successful candidate will perform crystallization, crystal optimization, and structure determination of protein-ligand complexes and will work in collaboration with medicinal and computational chemists. The successful candidate will also work closely with molecular biologists and protein biochemists and will have access to automated cloning, expression, and crystallization technologies. *Sr. Scientist, Chemistry West Point, PA Job # CHE003955* Productive and collaborative interactions with other members of the global, cross-functional department are a must. Cooperative and collaborative use of internal expertise will be essential to success. The position requires active interaction with the scientific community to continually improve scientific understanding, including presentations at national or international meetings. The specific responsibilities of the candidate include but are not limited to: - Design, conduct, interpret and report in vitro and/or in vivo immunology studies using a wide range of established methodologies. - Ensure data generated is communicated in a concise, easy to understand manner to the appropriate teams and stakeholders. Develop new methods and protocols de novo when and where needed. Monitor, review and critically interpret published work to guide internal research. - Actively contribute scientifically to immunological drug discovery research programs, including identification and validation of novel targets. - Collaborate with members from other functional groups, including medicinal chemistry, in vivo and in vitro pharmacology and translational sciences. - Work with external academic, biotechnology, and contract research organizations. - Mentor and guide other scientists in the group. Note: There are 3 positions available. *Qualifications:* - PhD degree with 2- 3 years postdoctoral training in membrane protein crystallography. - Demonstrated capability to design and execute X-ray crystallographic structure determination using all modern techniques, including molecular replacement and experimental phasing. - Demonstrated potential to develop project management skills and identify/develop new areas of scientific expertise in protein crystallography. - Excellent communication skills (written, presentation, and oral) that enhance team-based progress is required. Application of those skills both within and outside the department to ensure the maximum understanding of program status for therapeutic area project teams and management is required. - Ability to work effectively within timelines. - Ability to prepare peer-reviewed publications. PREFERRED SKILLS: - State-of-the-art knowledge of GPCR structural biology techniques including all aspects of GPCR construct design, expression, solubilization, purification, crystallization screening/optimization (including LCP and LCP-FRAP), and structure determination/analysis a significant plus. - Experience in the application of biophysical and functional characterization methods (e.g., protein NMR, Biacore, Thermofluor, ligand binding and receptor modality) to guide protein construct optimization for crystallography is a plus. Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. To be considered for this position, please visit: https://merck.taleo.net/careersection/ext_merckunitedstates_en/jobdetail.ftl Merck is an equal opportunity employer, M/F/D/V - proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard Reserves - We value your past and present service.
[ccp4bb] Job Posting on Behalf of Albert Einstein College of Medicine
*POST-DOCTORAL POSITION* Three post-doctoral positions are available to join a multi-disciplinary research group investigating the regulation of biological motors activity from the cellular to the molecular level. The group is formed by the laboratories of Gary Gerfen, Ao Ma, David Sharp and Hernando Sosa in the Department of Physiology and Biophysics of the Albert Einstein College of Medicine. For these positions the ideal candidates would have experience in the general areas of cell biology, structural biology, molecular simulation and statistical mechanics. Expertise with one or more of the following techniques will be required: protein expression and purification, cell imaging, electron paramagnetic resonance (EPR), electron microscopy and molecular dynamics simulations. For this project we have state of the art facilities present in each of the participating laboratories and at the core facilities of the Albert College of Medicine. These capabilities include EPR (PELDOR, high frequency, HYSCORE), several modalities of fluorescence microscopy (con-focal, epi, tirf, single-molecule polarization etc), cryo-electron microscopy and state-of-the-art Linux clusters for molecular simulations. All four laboratories in the group are located in the Albert Einstein College of Medicine in New York City, which offers excellent opportunities for stimulating and highly inter-disciplinary scientific interactions within the group, between theory/simulation and experiments, with the rest of the college and with many other scientific institutions in the New York area. Interested candidates please send an email letter, CV and reference names to either: Gary Gerfen (gary.ger...@einstein.yu.edu), Ao Ma (ao...@einstein.yu.edu), David Sharp (david.sh...@einstein.yu.edu), Hernando Sosa ( hernando.s...@einstein.yu.eduhttp://oneclick.jobtarget.com/Users/hsosa/AppData/Local/Microsoft/Windows/Temporary%20Internet%20Files/Content.Outlook/Q7O3XC8L/hernando.s...@einstein.yu.edu ). Yeshiva University is an equal opportunity employer committed to workforce diversity.
