[ccp4bb] Biochemist Postdoc Fellow to join the SIBYLS group at LBNL
We looking for a new team player in the SIBYLS group at the Lawrence Berkeley Lab. https://lbl.referrals.selectminds.com/jobs/biochemist-postdoc-fellow-3498 Lawrence Berkeley National Lab’s (LBNL) Biosciences Division has an opening for a Biochemist Postdoc Fellow to join the team. In this exciting role, you will develop and apply biophysical and biochemical techniques to address questions relevant to understanding structural cell biology for multi-component biological macromolecules. You will aid in the characterization of biological processes. You will be part of a team that designs, develops, and applies synchrotron methods to characterize macromolecules and the assemblies they form. Primary tools will include small angle X-ray scattering (SAXS). However accessible and ancillary techniques include X-ray crystallography, cryo-electron microscopy, and X-ray tomography. We seek to develop and improve overlaps with all techniques either in the joint application or through software development. You will develop and maintain software for SAXS analysis or the collection of SAXS data. You will work at the Advanced Light Source synchrotron and be required to develop interdisciplinary skills to communicate with other beamline staff, engineers, and physicists responsible for beamline application and development. Best Michal https://bl1231.als.lbl.gov/ _ Michal Hammel PhD Scientist at SIBYLS Beamline Advanced Light Source Lawrence Berkeley National Laboratory 1 Cyclotron Road MS 6R2100 Berkeley, CA 94720 (phone) 510-495-8179 (cell) 510-457-6317 _ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] Structural Biology Project Scientist Position at Advance Light Source, Berkeley
Hi all, Project scientist position is available at Adance Light Source, Berkeley. You will work on a project that will integrate Small Angle X-ray scattering (SAXS) , macromolecular X-ray crystallography (MX) and Soft X-ray tomography (SXT) cell imaging to study structure and function of macromolecular complexes. The project will be carried out at the SIBYLS beamline and National Center for X-ray Tomography at the Advanced Light Source (ALS). you can apply here: https://lbl.referrals.selectminds.com/jobs/biochemist-project-scientist-2579 the group: https://sibyls.als.lbl.gov/ Best, Michal -- _ Michal Hammel PhD Scientist at SIBYLS Beamline Advanced Light Source Lawrence Berkeley National Laboratory 1 Cyclotron Road MS 6R2100 Berkeley, CA 94720 (phone) 510-486-5378 (cell) 510-457-6317 _ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
[ccp4bb] 10th annual bioSAXS workshop October 2-3
Dear all, On October 2nd -3rd SIBYLS hosting 10th annual bioSAXS workshop. Full details schedule of talks and practical tutorials can be found here: https://bl1231.als.lbl.gov/ Date: October 2 - 3, 2019 Location: Advanced Light Source at the Lawrence Berkeley National Laboratory, Berkeley, CA This two-day workshop will cover frontiers in biological SAXS and will provide participants with software tutorial sessions for biological SAXS in addition to hands-on training in experimental techniques. The latest advances in SAXS studies on biological systems will be discussed with a particular focus on dynamic and flexible structures in biomolecules, membrane protein scattering, and complementary methods in crystals and in solution. Updates on current developments of software for SAXS analysis and solution structure modeling will be illustrated. The first day of the workshop will begin with a brief run-through on current updates. Greg Hura and Michal Hammel, Berkeley Lab’s SAXS beamline scientists, will introduce the capabilities of the mail-in program at SIBYLS and the future of high-throughput and SEC-SAXS at the SIBYLS Beamline. Distinguished speakers will contribute to the basis of the workshop over the two days by sharing complementary experimental approaches and modeling techniques. This will provide for a flux of ideas among workshop participants and inspire new perspectives for future data analysis. The second day will be dedicated to practical hands-on exercises with experts in SAXS software for data processing (SCATTER, FrameSlice and RAW, SAXS similarity maps, modeling tools (FOXS - MultiFoXS, BILBOMD and SAXS shape calculator). Enrollment is limited to 30 participants. Inquiries: Kathryn Burnett Registration: Registration is now open. To attend the workshop, you need to REGISTER for the 2019 ALS user meeting. When you register, indicate that you plan to attend the “10th Annual SIBYLS bioSAXS Workshop”. SCHEDULE: October 2nd, 2019 BioSAXS Workflow 8:30-8:40 Introduction to the SIBYLS team and Workshop Agenda (Hammel) 8:40 - 9:20 Key Note - Mark Glover (Uni. Alberta) Building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time 9:20 - 10 SAXS basics (Hura) 10 - 10:20 Break 10:20 - 12:20pm HT-SAXS, details of collection, getting intensity vs q (Burnett and Hura) 12:20 - 1:30 Lunch 1:30 - 2:30 SEC-SAXS-MALS, details of collection, getting intensity vs q (Hammel and Rosenberg) 2:30 - 3:00 ALS and beamline tour (SIBYLS team) 3:00 - 3:30 Intensity vs q to Shape (Hura) 3:30- 3:50 Break 3:50 - 4:10 Ben Horst (UC Berkeley) Allosteric activation of the NO receptor soluble guanylate cyclase revealed by cryo-EM and SAXS 4:10 - 4:30 Lauren Carter (University of Washington) De novo protein design validated by SAXS 4:30 - 4:45 Soumya Remesh (NCI) Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling 4:45 - 5 Curtis Hodge (LBNL) Functionalized Nanocage for Antibody Display October 3rd, 2019 Beyond Shapes with SAXS 8:30 - 9:15 HT-SAXS examples (Hura) 9:20 - 10 Special SEC-SAXS-MALS tools with Scatter and Evolving SVD (Hammel) 10 - 10:20 Break 10:20 - 12:20pm Invited User Talks 12:20 - 1:30 Lunch 1:30 -2:00 BilboMD (Hammel) 2:00-5:00 Hands on practical -- _ Michal Hammel PhD Scientist at SIBYLS Beamline Advanced Light Source Lawrence Berkeley National Laboratory 1 Cyclotron Road MS 6R2100 Berkeley, CA 94720 (phone) 510-486-5378 (cell) 510-457-6317 _ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
[ccp4bb] postdoctoral positions available at SIBYLS, Advance Light Source, Lawrence Berkeley National Laboratory
Details below for a postdoctoral position now open with the SIBYLS group at the Advanced Light Source as part of a collaborative project between Lawrence Berkeley National Laboratory (LBNL) and the National Cancer Institute (NCI). Please Email Jane Tanamachi (jtanama...@lbl.gov) for more information or questions. Are you looking to apply your skills in Integrative Structural Biology to the development of new approaches to explore organization of functional bacterial chromosome? The SIBYLS Group at Lawrence Berkeley National Laboratory is seeking a Postdoctoral Fellow in the field of Integrative Structural Biology. The SIBYLS group utilizes a multidisciplinary approach to study the structures and functional mechanisms of large macromolecular assemblies in promoting chromatin reorganization and transcriptional regulation. Our long-term goal is to modulate the functions of important DNA control elements and regulatory proteins or RNA’s for the prevention and treatment of various microbial infections or cancers. SIBYLS is also a world class synchrotron resource for structural biologists located at the Advanced Light Source, Lawrence Berkeley National Lab. SIBYLS scientists maintain productive research programs in chromatin remodeling, DNA damage responses, and genome stability. In addition, SIBYLS staff has excellent access and exposure to unique facilities, including the National Center for X-ray Tomography, the Joint Genome Institute sequencing facility, and the Molecular Foundry nanoscience facility. The SIBYLS group also has strong interactions with its neighbor, the University of California Berkeley, providing an unmatched research environment that combines a world-class academic research environment with unique national user facilities. Essential:Under the general supervision of Dr. Michal Hammel (LBNL) perform research including molecular and biophysical analyses of nucleoprotein assemblies in vitro and cellular imaging at the mesoscale. Approaches to be used include: (1) Soft X-ray tomography at the cell level (2) Static and time-resolved studies by small angle X-ray scattering (SAXS) at the nanoscale level (3) Crystallographic studies at the atomic scale (4) Integration of crystallographic structures, solution data and cell imaging to obtain biologically relevant structures (5) Biochemical and biophysical assays of complexes to define conditions that affect their assembly and activities. (6) In the collaboration with Dr. Sankar Adhya (NCI) integrate results from specialized cellular biology techniques. Candidates for postdoctoral positions should: · Hold or will have a Ph.D. degree in biophysics, bioinformatics, biochemistry or cell biology · Passionate about using structural data to influence key scientific decisions · Strong hands-on skills in molecular biology and protein biochemistry · Proven ability to write own scripts in Linux environment and to utilize cheminformatics tools · Broad knowledge in protein characterization, biophysics and bioinformatics with experience in homology modeling and simulation will be helpful to drive projects forward · Outstanding candidates with different skill sets will be taken into consideration, spanning from structural biologists with experience in structural biology to cell biologists. · Experiences in SAXS, SXT or Cryo-EM preferred but not mandatory Period: one year position with possibility of renewal Links: http://sibyls.als.lbl.gov/ <http://sibyls.als.lbl.gov/> http://ncxt.lbl.gov/ <http://ncxt.lbl.gov/> http://newscenter.lbl.gov/2016/07/29/molecular-switch-triggers-bacterial-pathogenicity/ <http://newscenter.lbl.gov/2016/07/29/molecular-switch-triggers-bacterial-pathogenicity/> ______ Michal Hammel PhD Scientist at Advanced Light Source Lawrence Berkeley National Laboratory 1 Cyclotron Road MS 6R2100 Berkeley, CA 94720 (phone) 510-495-8179 (cell) 510-457-6317 mham...@lbl.gov
