[ccp4bb] Fwd: [ccpem] Tenure track scientist position at PSI (focus on cryo-ET)

[Schertler Gebhard (PSI)]

Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OSRA 007
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265

Anfang der weitergeleiteten Nachricht:

Von: "Korkhov Volodymyr (PSI)" 
Datum: 12. Dezember 2021 um 09:38:42 MEZ
An: cc...@jiscmail.ac.uk
Betreff: Aw: [ccpem] Tenure track scientist position at PSI (focus on cryo-ET)
Antwort an: "Korkhov Volodymyr (PSI)" 

Dear all,

This is a gentle reminder that the deadline for the tenure-track cryo-EM 
scientist position at PSI is coming up in 3 days (15th of December).

Best,
Vladimir


On 12 Nov 2021, at 15:25, Vladimir Korkhov  wrote:

The group of Volodymyr Korkhov at Paul Scherrer Institute, Villigen, 
Switzerland is looking to fill a position of a Scientist (Tenure Track), with a 
focus on cryo-electron tomography. The scientist will use cryo-electron 
tomography and single particle analysis to study the structure and organisation 
of membrane protein complexes involved in cellular signalling.

Your tasks:
- Leading new research projects on cryo-EM structure determination of membrane 
proteins within the Mechanisms of signal transduction group, including 
collaborations
- Support of ongoing research projects, including training of PhD students and 
postdocs
- Implementation and development of advanced data collection and image 
processing methods, including cryo-ET & sub-tomogram averaging and single 
particle analysis

Your profile:
- PhD degree in a life science-related discipline
- Strong background on cryo-ET and/or single particle analysis data collection 
and processing
- Capable of performing the full range of cryo-EM workflows, from sample 
preparation to data interpretation
- Interested in membrane biology
- Expertise in data science / programming, FIB-SEM, cell biology or 
biochemistry will be an advantage
- Your are a highly motivated person and able to work in an international team
- It is expected that your are a communicative person, innovative and 
open-minded for new ideas

We offer:
- Access to the EM facility at PSI and to ScopeM at ETH Zurich (equipped with a 
wide range of state of the art equipment, including three Titan Krios 
microscopes)
- Access to all shared research infrastructure and research platforms at PSI 
and at ETH Zurich

Our institution is based on an interdisciplinary, innovative and dynamic 
collaboration. You will profit from a systematic training on the job, in 
addition to personal development possibilities and our pronounced vocational 
training culture. If you wish to optimally combine work and family life or 
other personal interests, we are able to support you with our modern employment 
conditions and the on-site infrastructure.

This is a Tenure Track position. The employment contract will initially be 
limited to 3 years.

For further information, please contact Prof Dr. Volodymyr Korkhov, phone +41 
56 310 28 42, e-mail: volodymyr.kork...@psi.ch.

Please submit your application online by 15 December 2021 (including list of 
publications and addresses of referees) for the position as a Scientist (Tenure 
Track) (index no. 2318-01).

The full job advertisement can be found here:
https://www.nature.com/naturecareers/job/scientist-tenure-track-focus-on-cryoelectron-tomography-paul-scherrer-institute-psi-749597



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[ccp4bb] Scientist (Tenure Track) | Education and Jobs | Paul Scherrer Institut (PSI)

[Schertler Gebhard (PSI)]

https://www.psi.ch/en/pa/job-opportunities/48619-scientist-tenure-track




Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OSRA 007
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265



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[ccp4bb] Fwd: [ccpem] registration deadline extended until tomorrow - Cellular Structural Biology & Bioimaging symposium, Oct 26-27, 2021

[Schertler Gebhard (PSI)]

Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OSRA 007
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265

Anfang der weitergeleiteten Nachricht:

Von: Vladimir Korkhov 
Datum: 10. Oktober 2021 um 11:26:23 MESZ
An: cc...@jiscmail.ac.uk
Betreff: [ccpem] registration deadline extended until tomorrow - Cellular 
Structural Biology & Bioimaging symposium, Oct 26-27, 2021
Antwort an: Vladimir Korkhov 

Dear all,

We have extended the deadline to register and submit the abstract for the 
online symposium Cellular Structural Biology & Bioimaging to Monday, 11th of 
October.

The symposium is organised by scientists at PSI, ETH Zurich, University of 
Zurich and University of Bern: 
https://ictac.events.idloom.com/lnb-conference2021

The program of the symposium already includes an outstanding panel of invited 
speakers, as well as the submitted abstracts/poster presentations - many thanks 
to all who have submitted their abstracts! In case you have not yet registered 
or submitted your abstract, we will be happy to receive your registration 
and/or abstract latest by Monday, 11th of October.

Best,
Vladimir Korkhov




Prof. Dr. Volodymyr M. Korkhov

Associate Professor
Institute of Molecular Biology and Biophysics
ETH Zurich

Paul Scherrer Institute
OSRA/001
5232 Villigen PSI, Switzerland
tel: +41 56 310 28 42
e-mail: volodymyr.kork...@psi.ch




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[ccp4bb] Professor in Physics of Imaging / Ecole polytechnique fédérale de Lausanne (EPFL) and Head of Mathematics and Physics of Imaging / Paul Scherrer Institut (PSI) ‒ Working ‐ EPFL

[Schertler Gebhard (PSI)]

https://www.epfl.ch/about/working/professor-in-physics-of-imaging-ecole-polytechnique-federale-de-lausanne-epfl-and-head-of-mathematics-and-physics-of-imaging-paul-scherrer-institute-psi/




Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265



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[ccp4bb] Search for Assistant Professor in Biophysics at the University of Wisconsin Milwaukee

[Schertler Gebhard (PSI)]

Search for Assistant Professor in Biophysics at the University of Wisconsin 
Milwaukee



Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OSRA 007
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265








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BioPhysics Search ad Sept 15, 21.pdf
Description: BioPhysics Search ad Sept 15, 21.pdf

[ccp4bb] Poster submission 4th ERNEST GPCR meeting open till 7th April

[Schertler Gebhard (PSI)]

Poster submission 4th ERNEST GPCR meeting open till 7th April

https://ernestcostaction.wixsite.com/website/poster-flash-talks

https://ernestcostaction.wixsite.com/website


Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OSRA 007
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265








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[ccp4bb] Welcome | ERNEST Meetings

[Schertler Gebhard (PSI)]

https://ernestcostaction.wixsite.com/website




Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265



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[ccp4bb] Experienced Technician in membrane protein expression and purification

[Schertler Gebhard (PSI)]

We are extending our efforts in Corona virus research immediatly.

I urgently would need experienced Technition for membrane protein expression 
purification crystallization and cryo-EM.
Membrane Protein Biochemistry and experience with Baculo virus and ticue 
culture essential. at lest two years of experience. Swiss located preferred 
because of urgency.

Exiting project to support serology and structural Biology directly in my group 
in collaboration with Adriano Aguzzi.
contact Gebhard Schertler. Advert on PSI site will go live as soon as possible.
Recommendations welcome.

Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OSRA 007
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265







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[ccp4bb] Fwd: Retinal Proteins Conferences - Historical Website

[Schertler Gebhard (PSI)]

Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265

Anfang der weitergeleiteten Nachricht:

Von: Leonid Brown mailto:lebr...@uoguelph.ca>>
Datum: 28. September 2019 um 04:34:11 MESZ
An: Undisclosed recipients:;
Betreff: Retinal Proteins Conferences - Historical Website

Dear colleagues,

I am happy to announce that we launched a historical website dedicated to past 
ICRPs (International Conferences on Retinal Proteins), at 
http://icrp2018.retinalproteins.org/. I want to thank everyone who provided the 
historical materials and Rob Reedijk (University of Toronto) for his work on 
the website design.

As you will see from perusing the site, it is a beta version and some pages are 
incomplete. So I encourage you to send any materials you will find missing from 
those pages, especially on some of the older conferences.

Thank you in advance for your support. Feel free to send the link to anyone who 
may be interested.

Best regards Leonid


Leonid S. Brown, Ph.D.
Professor, Department of Physics,
Associate Dean of Research and Graduate Studies, CEPS,

University of Guelph, Ontario N1G 2W1, Canada
phone, voice mail: 519-824-4120 x53295 or x53777
https://www.physics.uoguelph.ca/people/leonid-s-brown
email: lebr...@uoguelph.ca




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[ccp4bb] Symposium on Structure Biology for Drug Discovery@SwissFEL

[Schertler Gebhard (PSI)]

Dear colleagues

I would like to invite you to an interesting event focusing on XFEL and Cryo-EM 
science. we have an amazing line-up of speakers. Also Switzerland is always 
worth a visit!

I am excited to announce the final agenda for the International Symposium on 
Structure Biology for Drug Discovery@SwissFEL taking place from June 25th-27th 
in Villigen, Switzerland!

Check out the program on http://indico.psi.ch/e/ISDD Online registration is 
open until 9 Jun 2019

Kind regards
Gebhard

Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265






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[ccp4bb] On behalf Abbas Ourmazd: Machine-learning Opportunities

[Schertler Gebhard (PSI)]

Abbas Ourmazed has developed interesting data analysis approaches to XFEL and 
Cryo-EM data they apply simmilar strategies to other typs of data.



Machine-learning Opportunities at the University of Wisconsin Milwaukee

The Data Science/Machine Learning group in the Department of Physics plans to 
hire up to three postdoctoral associates in applications of machine learning to 
physics and biology.

We seek outstanding candidates to pioneer the development and application of 
advanced machine learning techniques to key problems at the forefront of 
science. While familiarity with machine learning would be an advantage, 
exceptional candidates will receive serious consideration regardless of 
background.

Please send applications (cover letter, resume & publications list) to Prof. 
Abbas Ourmazd [ourm...@uwm.edu].







Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürih D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265






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[ccp4bb] Paul Scherrer Institut (PSI) :: Postdoctoral Fellow

[Schertler Gebhard (PSI)]

https://www.psi.ch/pa/stellenangebote/1997




Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265



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[ccp4bb] Cryo EM at ETH

[Schertler Gebhard (PSI)]

https://www.ethz.ch/content/dam/ethz/special-interest/dual/scopem/PDFs/Senior%20scientist%20-%20expert%20in%20Cryo%20Electron%20Microscopy%20(002).pdf





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Senior scientist - expert in Cryo Electron Microscopy (002).pdf
Description: Senior scientist - expert in Cryo Electron Microscopy (002).pdf
Prof. Gebhard F.X. SchertlerStructural Biology ETH Zürich D-BIOLHead of Biology and ChemistryDivisionPaul Scherrer InstitutLaboratory of Biomolecular Research, LBROFLC 109CH-5232 Villigen PSIgebhard.schert...@psi.chphone +41 56 310 4265


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[ccp4bb] This time, it's all bio: SwissFEL makes protein structures visible | Paul Scherrer Institut (PSI)

[Schertler Gebhard (PSI)]

https://www.psi.ch/media/this-time_-its-all-bio-swissfel-makes-protein-structures-visible




Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265



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[ccp4bb] 1100_Stabsmitarbeiter_in_PSI.PDF

[Schertler Gebhard (PSI)]

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1100_Stabsmitarbeiter_in_PSI.PDF
Description: 1100_Stabsmitarbeiter_in_PSI.PDF
Prof. Gebhard F.X. SchertlerStructural Biology ETH Zürich D-BIOLHead of Biology and ChemistryDivisionPaul Scherrer InstitutLaboratory of Biomolecular Research, LBROFLC 109CH-5232 Villigen PSIgebhard.schert...@psi.chphone +41 56 310 4265


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[ccp4bb] Second Call PSI Fellow

[Schertler Gebhard (PSI)]

PSI-FELLOW-II-3i: EU SUPPORTED MARIE-SKłODOWSKA-CURIE FELLOWSHIP PROGRAMME - 
CALL FOR APPLICATIONS
The second call for applications under our Marie Skłodowska-Curie Programme 
called PSI-FELLOW-II-3i will be launched on the 1st of September with deadline 
on the 30th of November 2018.
2017-2021, PSI-FELLOW-II-3i offers 60 scientists and engineers challenging 
opportunities in i) materials and matters, ii) life-sciences, iii) energy and 
environment and iv) accelerator technologies.

The programme provides an excellent possibility for work, research and constant 
training to those who are interested in science and technology at the highest 
level.

PSI-FELLOW-II-3i is financially supported by the European Commission (GA 
701647/Horizon 2020).


Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265



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Re: [ccp4bb] Off-topic: protein 2d diagrams

[Schertler Gebhard (PSI)]

Try

http://gpcrdb.org/

They have a tool for snake plots of GPCRs

Best
Gebhard



Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265

Am 04.08.2018 um 10:38 schrieb Joana Pereira 
mailto:joana.pere...@tuebingen.mpg.de>>:

Dear CCP4 community,

I have seen many papers with detailed protein 2d diagrams like this one:

<2D-transmembrane-protein-diagram-A-convenient-representation-of-the-receptor-sequence.jpeg>
However, I can never find a reference for any tool that can compute such 
diagrams from a 3D structure. Do you know of any?

Many thanks and enjoy the warm weather!

Joana


—
Dr. Joana Pereira
Postdoctoral Researcher
Department of Protein Evolution

Max Planck Institute for Developmental Biology
Max-Planck-Ring 5
72076 Tübingen
GERMANY



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[ccp4bb] Opportunity for time resolved FEL crystallography

[Schertler Gebhard (PSI)]

We  are looking for Postdocs that are willing to apply for Fellowships in my 
group at PSI.
SwissFEl is now operating, which opens very unique opportunities for time 
resolved room temperature crystallography. We developed several membrane 
protein projects that need crystallography support. An interest in chemical 
mechanism, kinetics  and a good background in biophysics and crystallography 
are essential. The maximal length of appointment as a postdoc at PSI would be 4 
years.

Please contact me directly by e-mail

Gebhard Schertler

Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265






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[ccp4bb] Paul Scherrer Institut (PSI) :: Staff Scientist

[Schertler Gebhard (PSI)]

https://www.psi.ch/pa/stellenangebote/1760

Paul Scherrer Institut (PSI)
The Paul Scherrer Institute PSI is the largest research institute for natural 
and engineering sciences within Switzerland. We perform cutting-edge research 
in the fields of matter and materials, energy and environment and human health. 
By performing fundamental and applied research, we work on sustainable 
solutions for major challenges facing society, science and economy. PSI is 
committed to the training of future generations. Therefore about one quarter of 
our staff are post-docs, post-graduates or apprentices. Altogether PSI employs 
2100 people.

Within the Electron Microscopy Group (EMF) we have a strong user community for 
biology research projects taking advantage of the availability of our two 
transmission electron microscopes. The main focus is cryo tomography, single 
particle analysis and electron diffraction. Our high-end 200 keV TEM equipped 
with two direct electron detectors allows high-end data acquisition and the 
development of new techniques. For this group we are looking for a

Staff Scientist
Your tasks
As a part of a highly skilled and motivated team you will be involved in 
maintaining and further developing hard- and software in collaboration with PSI 
groups working in biology and development, in user training as well as 
implementing new techniques at the facility.


  *   Technical support for the 2 transmission electron microscopes at the EMF 
including daily maintenance
  *   Introductory trainings to new users at the EMF
  *   Advise and support scientists (mainly withing biological context) with 
their experiments at the EMF
  *   Further development of existing and implementation of novel technologies 
and procedures for the analysis and interpretation of cryo-electron microscopy 
data of biological specimens
  *   Expert support in sample preparation of biological specimens using the 
high pressure freezer and vitrobot at the facility
  *   Close collaboration with the manager of the facility for maintaining 
hard- and software and establishing new techniques at the facility
  *   Supporting and advancing important projects at the facility: high end 
single particle analysis, electron diffraction methods and electron ptychography

Your profile

  *   University degree at PhD level or equivalent in natural sciences
  *   Strong background and hands-on experience in electron microscopy is 
required
  *   Experience in cryo EM technologies (hardware and software)
  *   Strong interest in biological projects using electron imaging methods
  *   Strong communication and collaboration skills in an international 
environment
  *   Fluent communication in English
  *   Previous experience in user support and/or EM user facility is a strong 
plus

We offer
Our institution is based on an interdisciplinary, innovative and dynamic 
collaboration. You will profit from a systematic training on the job, in 
addition to personal development possibilities and our pronounced vocational 
training culture. If you wish to optimally combine work and family life or 
other personal interests, we are able to support you with our modern employment 
conditions and the on-site infrastructure.

This is a Tenure Track position. The employment contract will initially be 
limited to 3 years.

For further information please contact Dr Elisabeth Müller, phone +41 56 310 54 
11.

Please submit your application online (including list of publications and 
addresses of referees) for the position as a Staff Scientist (index no. 
2315-01).

Paul Scherrer Institut, Human Resources Management, Sevil Minniti, 5232 
Villigen PSI, Switzerland




Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265

[ccp4bb] Paul Scherrer Institut (PSI) :: Scientist

[Schertler Gebhard (PSI)]

https://www.psi.ch/pa/job-opportunities/1753




Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265

[ccp4bb] PHD Position at PSI

[Schertler Gebhard (PSI)]

We are seeking a highly motivated and skilled PhD student for a protein 
engineering / structural biology project at the Paul Scherrer Institute (PSI) 
in Villigen, Switzerland. The aim of the project will be to engineer membrane 
proteins and membrane protein complexes that are suited for analysis by 
cryo-electron microscopy (cryo-EM) from single particles. The project will 
involve molecular cloning, protein expression in E. coli and mammalian cells, 
protein purification, biophysical characterization and analysis by electron 
microscopy. Ideally, the student should have a strong interest in molecular and 
structural biology and a strong interest in the newest structural biology 
methods. Experience in electron microscopy, protein expression in E. coli and 
mammalian cells, molecular cloning and protein purification would be highly 
beneficial. The project will be supervised by Dr. Roger Benoit and 
co-supervised by ETH Prof. Dr. Gebhard Schertler.
Prof. Gebhard F.X. Schertler
Structural Biology ETH Zürich D-BIOL

Head of Biology and Chemistry
Division
Paul Scherrer Institut
Laboratory of Biomolecular Research,
LBR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265

[ccp4bb] Paul Scherrer Institut (PSI) :: PSI-FELLOW-II-3i / Postdoctoral Fellows

[Schertler Gebhard (PSI)]

https://www.psi.ch/pa/stellenangebote/1391



Prof. Gebhard F.X. Schertler 
Head of Biology and Chemistry 
Paul Scherrer Institut 
Laboratory of Biomolecular Research, BMR 
OFLC 109 
CH-5232 Villigen PSI 
gebhard.schert...@psi.ch 
phone +41 56 310 4265 

[ccp4bb] Fwd: [ccpem] Postdoctoral position in cryo-EM of membrane protein complexes at PSI

[Schertler Gebhard (PSI)]

Prof. Gebhard F.X. Schertler
Head of Biology and Chemistry
Paul Scherrer Institut
Laboratory of Biomolecular Research, BMR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.ch
phone +41 56 310 4265

Anfang der weitergeleiteten E‑Mail:

Von: "Korkhov Volodymyr (PSI)" 
>
Datum: 30. September 2016 um 14:04:02 MESZ
An: >
Betreff: [ccpem] Postdoctoral position in cryo-EM of membrane protein complexes 
at PSI
Antwort an: "Korkhov Volodymyr (PSI)" 
>

A postdoctoral position is available in the group of Prof. Volodymyr M. Korkhov 
at Paul Scherrer Institute (PSI) and ETH Zurich, to work on structure and 
function of membrane-associated signal transduction complexes using electron 
cryo-microscopy (cryo-EM) and single particle analysis.
The successful candidate will have expertise and a track record in cryo-EM and 
single particle analysis. The candidate will be experienced in molecular 
biology, including cloning, heterologous protein expression and purification. 
Previous experience with biochemistry of membrane proteins will be an advantage 
but not a prerequisite. The candidate will be able to work independently and 
will have excellent teamwork and communication skills.
The Korkhov group is integrated into the Laboratory of Biomolecular Research at 
PSI and has full access to all facilities and instruments for protein 
expression, purification, biochemical and biophysical analysis. In addition, 
the group benefits access to the PSI crystallization facility and the Swiss 
Light Source synchrotron radiation facility. The group benefits from the 
in-house 200 kV screening transmission electron microscope (JEOL JEM2200), 
planned to be upgraded with a direct electron detector. Furthermore, the group 
has full access to all research facilities at ETH Zurich, including the K2 and 
Falcon II direct detector-equipped Titan Krios microscope at the ETH Scientific 
Centre for Optical and Electron Microscopy (ScopeM).
Working at PSI provides many benefits, including integration into the PSI/ETH 
Zurich scientific community, high standard of living and a competitive salary. 
This position is offered for one year initially, and is extendable to up to 
four years. The candidate will be expected to obtain a postdoctoral mobility 
fellowship within the first year.
For informal enquiries or to apply for this position the interested candidates 
should send an e-mail to 
volodymyr.kork...@psi.ch. The application 
should include a cover letter describing the candidate`s research interests and 
motivation to apply, the CV and list of publications, and contact details of 
three referees. Additional information can be found here: 
https://www.psi.ch/lbr/korkhov_-volodymyr.

[ccp4bb] Technic assistant PSI / schertler

[Schertler Gebhard (PSI)]

Website: http://www.psi.ch/lbr/


Technical Assistant

Membrane Protein Production, Purification and Crystallisation

Laboratory of Biomolecular Research – Schertler Lab

Paul Scherrer Institute, Switzerland

Description
The Paul Scherrer Institute PSI is the largest research centre for natural and 
engineering sciences within Switzerland. We perform cutting-edge research in 
the fields of matter and materials, energy and environment and human health. By 
performing fundamental and applied research, we work on sustainable solutions 
for major challenges facing society, science and economy. PSI is committed to 
the training of future generations. Therefore about one quarter of our staff 
are post-docs, post-graduates or apprentices. Altogether PSI employs 1900 
people.
The Laboratory of Biomolecular Research (LBR) 
(http://www.psi.ch/lbr/laboratory-of-biomolecular-research) in the Biology and 
Chemistry department of the Paul Scherrer Institute counts around 80 people 
pursuing fundamental research in large part in the field of transmembrane 
signalling. We work on membrane proteins that are essential for many biological 
processes and therefore are the targets of more than 30% of the drugs on the 
market. Research at LBR is therefore strongly linked to human health trough 
collaborations with academic laboratories and pharmaceutical industries.
With the very close proximity of the Swiss Light Source (SLS) synchrotron, the 
development of projects for studies at the swiss Free Electron Laser under 
construction (SwissFEL) and its excellent infrastructure, the LBR is an 
attractive environment for technical employees, PhD students and postdocs 
interested in structure/function analysis of complex biological systems.

Duties  Responsibilities:
-Dedicated support to the research projects in the group of Gebhard Schertler 
as well as maintenance of basic functions in the lab. Your main activity will 
be conducting experiments with protein production (PCR, plasmid preparation, 
bacterial and eukaryotic cell culture), protein isolation followed by 
biochemical characterisation (chromatography techniques, SDS-PAGE, Western 
blotting, stability tests and ligand binding assays) and crystallisation 
(manual and robotic setting up). You will carry out some experiments in 
low-light conditions in a photolab and occasionally give assistance during 
diffraction measurements of crystal samples at the SLS synchrotron which 
require some flexibility in the working hours.
-A part of the job (20%) will support the general LBR infrastructure and 
laboratory workflow both in an independent manner and in collaboration with the 
group.

Requirements:
As an ideal candidate, you must have a minimum education as technical assistant 
with some experience in biochemistry. You should have knowledge in protein 
production and purification and be highly motivated in working on fundamental 
research with protein and DNA. You are able to work as part of a team and 
independently with excellent communication in English. Keeping an electronic 
labbook as well as organisational (inventories) and basic administrative skills 
are essential.
A bachelor degree in biochemistry or chemistry, German knowledge, experience in 
cell culture, protein purification and/or crystallization is an advantage.

We offer:
Our institution is based on an interdisciplinary, innovative and dynamic 
collaboration. You will profit from a systematic training on the job, in 
addition to personal development possibilities and our pronounced vocational 
training culture. If you wish to optimally combine work and family life or 
other personal interests, we are able to support you with our modern employment 
conditions and the on-site infrastructure.
Your employment contract is first limited to 2 years

For further information please contact Valérie Panneels 
(valerie.panne...@psi.chmailto:valerie.panne...@psi.ch)

Please submit your application online (including letters of reference) for the 
position of reference “2011-01” athttp://www.psi.ch/pa/offenestellen/1010.


Prof. Gebhard F.X. Schertler
Head of Biology and Chemistry
Paul Scherrer Institut
Laboratory of Biomolecular Research, BMR
OFLC 109
CH-5232 Villigen PSI
gebhard.schert...@psi.chmailto:gebhard.schert...@psi.ch
phone +41 56 310 4265