[ccp4bb] PhD studentship available

[Littlechild, Jennifer]

We have a BBSRC supported PhD studentship with Unilever which is advertised 
from Biosciences on the University of Exeter UK web site with a closing date 
12th September.
The overall proposal will be to evaluate and take forward the application of 
already identified thermophilic lactonase enzymes from three different enzyme 
classes to combat microbial biofilm formation towards the improvement of 
Unilever's Healthcare Products. The student will also search through a 
thermophilic genomic and metagenomic DNA database available at Exeter for 
additional related enzymes.
Students with experience in bioinformatics, molecular biology techniques 
including cloning and protein over-expression, protein purification and 
biochemical and structural characterisation, are encouraged to apply on the 
University web site and contact me by email 
j.a.littlech...@exeter.ac.uk as necessary.
Applicants must have obtained, or be about to obtain, a First or Upper Second 
Class UK Honours degree in Biological Chemistry or Biochemistry, or the 
equivalent qualifications gained outside the UK, in an appropriate area of 
science or technology.

Prof of Biological Chemistry, Emeritus, FRSB,FRSC
Henry Wellcome Building for Biocatalysis.
College of Life and Environmental Sciences, Biosciences,
University of Exeter,
EX4 4PQ




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[ccp4bb] PhD studentship available

[Simon Kolstoe]

Dear all,

If you have any promising undergraduate or masters level students I would be 
grateful if you could point them to the following, funded, PhD opportunity in 
my laboratory. They are welcome to send me an email for an informal chat prior 
to an application.

"Molecular basis of C-reactive protein (CRP) binding to the lipid bilayer – a 
flag for complement targeting and the generation of pro-inflammatory signals in 
the innate immune system"

https://www.findaphd.com/search/ProjectDetails.aspx?PJID=81668=1286

Structural studies of biological macromolecules and their interactions underpin 
our understanding of function and guide the development of drug interventions 
to combat disease. The aim of this project is to define the structural detail 
of the interaction of the pentameric human acute phase C-reactive protein (CRP) 
with compromised lipid bilayers. This targets the innate immune system to 
resolve tissue damage, but also produces a monomeric variant of CRP that 
generates pro-inflammatory signals. The PhD project student will express and 
purify native and mutated forms of CRP from tissue culture cells, and 
crystallise the proteins in cubic lipid phase for structure analysis by X-ray 
diffraction methods. This will help to understand how CRP differentiates 
between sick and healthy cells. 

An experienced team working in the biophysics and crystallography of CRP will 
supervise the student. There will be opportunities to work at the Membrane 
Protein Laboratory (Harwell) and collect X-ray diffraction data at a 
synchrotron radiation source. In addition there will be access to a large 
number of training resources available through the graduate school including 
those geared toward improving presentation skills, time-management and project 
organisation skills, reviewing literature, thesis writing, data analysis and 
statistics, 
and related training modules. 

Portsmouth is a vibrant waterfront city on the south coast of England and is 
within easy reach of London. The city is compact and friendly with the 
university at its heart. More information about living in the city and working 
at the university can be seen here: http://www.port.ac.uk/virtualtour/

Funding Notes

Home/EU applicants only. Please use the online application form and state the 
project code (BIOL2900217) and studentship title in the personal statement 
section. 

Funds will be provided for 3 or 4 years which will include: bursary (at current 
RCUK rates), University fees (UK/EU rate).

Thanks,

Simon

[ccp4bb] PhD studentship available

[Dr Norbert Krauss]

Dear Colleague,

A BBSRC PhD studentship (for UK students only - EU students may be  
eligible for funding) is available for three years from October 2008  
to work in my laboratory at Queen Mary, University of London.


A provisional project title is Conformational changes during the  
photocycle of a bacterial phytochrome. Further information is  
available from


http://photosynthesis.sbcs.qmul.ac.uk/Krauss_PhDProject.pdf

The main requirement is for a motivated and qualified scientist with a  
commitment to solving important biological problems by means of  
structural analysis, including X-ray crystallography.


Please bring this opportunity to the attention of any interested  
graduate or final-year undergraduate in your research group or  
department.


Applicants are invited to apply at the earliest opportunity. The  
position is open until filled.


Best wishes,

Norbert Krauß

___

Dr Norbert Krauss
Senior Lecturer in Structural Biology

School of Biological and Chemical Sciences
Queen Mary, University of London
Walter Besant Building
Mile End Road
London E1 4NS
UK

Tel.:+44 20 7882 8445
e-mail:  [EMAIL PROTECTED]
http://www.sbcs.qmul.ac.uk/people/norbert_krauss.shtml
http://photosynthesis.sbcs.qmul.ac.uk/

[ccp4bb] PhD Studentship available for UK/EU residents

[Moody, Dr P.C.E.]

FULLY FUNDED STUDENTSHIP IN CHEMICAL BIOLOGY AVAILABLE FOR OCTOBER 2007

 

A fully funded PhD studentship is available for October 2007 start (to cover 
stipend, approx £13,000 per annum, and fees, approx £3000 per annum) in the 
area of chemical biology. It is a multidisciplinary project and will be jointly 
supervised by Professor Emma Raven 
http://www.le.ac.uk/chemistry/staff/el10.html  (Department of Chemistry) and 
Dr Peter Moody http://www.le.ac.uk/biochem/staff/pcem1/pcem1.html  
(Department of Biochemistry). The successful applicant will join an active 
collaborative research environment working at the chemistry/biology interface 
and the project will provide the successful applicant with an opportunity to 
interact with other biochemists and molecular biologists within the Centre for 
Chemical Biology http://www.le.ac.uk/chemistry/chembiol/  at Leicester. 

The project will be based in the new £22m Henry Wellcome Building for 
Biomedical Research and will involve an examination of transient catalytic 
intermediates in a heme-containing protein and will use structural, 
spectroscopic and kinetic techniques. There will be opportunities to interact 
with other groups in the Henry Wellcome Building and outside of Leicester, 
including frequent visits to synchrotron facilities in this country and abroad. 
You will be joining an active group of postdoctoral and postgraduate 
researchers working on various aspects of heme biochemistry and mechanism and 
will be exposed to a range of techniques and methodologies spanning the 
chemistry/biochemistry/molecular biology areas. The project would suit an 
ambitious individual looking to expand their expertise at the chemistry/biology 
interface. Prof Raven's and Dr Moody's laboratories are situated in the brand 
new £22m Henry Wellcome Building for Biomedical Research. We can offer 
state-of-the-art infrastructure to support your work and laboratories that are 
equipped to the highest standard. For further information on the range of 
activities on-going in both laboratories please visit the respective web sites 
(http://www.le.ac.uk/chemistry/staff/el10.html and  
http://www.le.ac.uk/biochem/staff/pcem1/pcem1.html 
http://www.le.ac.uk/biochem/staff/pcem1/pcem1.html ). 


How to apply 


Candidates should have, or expect to obtain, a first or upper second class 
degree in chemistry, biochemistry or a related discipline or equivalent. The 
position is open to UK or EU nationals. 

Interested applicants may contact Prof Emma Raven mailto:[EMAIL PROTECTED]  
or Dr Peter Moody mailto:[EMAIL PROTECTED]  for further information. To 
apply, please send CV plus details of two referees. 

 

 

 
Peter Moody
Henry Wellcome Laboratories of Structural Biology
Department of Biochemistry
Henry Wellcome Building
University of Leicester
LE1 9HN
0116 229 7097