[ccp4bb] Post-doctoral position available

[Page,Rebecca]

The Page Laboratory at the University of Connecticut Health Center has an 
immediate opening for up to two post-doctoral candidates to study pro- and 
eukaryotic signaling enzymes, with a focus on the function of phosphatases that 
form large signaling complexes, and also drug/inhibitor development. All 
studies use X-ray crystallography and/or cryo-EM/NMR. Applicants with a strong 
background in biochemical techniques, and especially eukaryotic protein 
expression and protein crystallization, are encouraged to apply.


The Page laboratory is housed in a newly renovated ~250,000 sq. ft. research 
laboratory in Farmington, CT. The laboratories are open-lab-space facilities 
and allow close interaction with the adjunct structural biology and 
molecular/cell biology groups at UConn Health. The Page laboratory is equipped 
with all necessary infrastructure to produce (E. coli, Sf9, mammalian), purify 
and analyze protein and protein complexes (ITC, SPR etc.) and crystallization 
robotics for crystal production.


Farmington, CT, is located on the New England between Boston (90 min.) and New 
York City (90 min.). Starting date, salary and project details are negotiable.

Please e-mail a Cover Letter and CV to Rebecca Page (rpage(at)uchc.edu).


Recent publications:

  *   Wang, X., Garvanska, DH, Nasa, I, Ueki, Y, Zhang G, Kettenbach, AN, Peti, 
W, Nilsson, J, Page, R (2020). A dynamic charge-charge interaction modulates 
PP2A:B56 substrate recruitment. eLife. 9. Pii: e55966.
  *   Choy, M.S., Moon, T.M., Ravindran, R., Bray, J.A., Robinson, L.C., 
Archuleta, T.L., Shi, W., Peti, W., Tatchell, K., Page, R. (2019) SDS22 
selectively recognizes and traps metal-deficient inactive PP1. PNAS 116:  
20472-20481.



Rebecca Page, PhD
Professor
UConn Health | Cell Biology (L5080)
263 Farmington Avenue | Farmington, CT 06030
rp...@uchc.edu

Page laboratory website



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[ccp4bb] Post-doctoral position available

[Jim Spencer, Cellular and Molecular Medicine]

Dear All,

A postdoctoral position is available in my lab to study the interactions of 
zinc-dependent (metallo) beta-lactamases with beta-lactam substrates and 
candidate inhibitors using both rapid kinetics and X-ray crystallography. 
The position will be offered for one year in the first instance but with a 
strong possibility of renewal.


Details of the post and application procedure are available at:

http://www.bris.ac.uk/boris/jobs/feeds/ads?ID=112771

or by informal enquiry to me.

Please note that, if interested, you will need to apply online through the 
link above.


Best wishes

Jim Spencer

--
Dr. James Spencer,
Lecturer in Microbiology
School of Cellular and Molecular Medicine
Medical Sciences Building
University of Bristol
University Walk
Bristol BS8 1TD
jim.spen...@bristol.ac.uk
http://www.bristol.ac.uk/cellmolmed/staff/spencer.html
--

Tel: (44) (0) 117 331 2084
Fax: (44) (0) 117 331 2091

[ccp4bb] Post-doctoral Position Available in Structural Biology and Epigenetics

[Jikui Song]

Sorry for posting again, previous message contains a typo.

A post-doctoral position is available for highly motivated candidates to join a 
research group interested in investigating molecular mechanisms underlying 
epigenetic regulation and inheritance, and the broad area of chromatin biology. 
Projects will involve structure determination of macromolecular complexes by 
X-ray crystallography and/or NMR spectroscopy, and related biochemical 
characterizations. Applicants should hold a PhD degree and have significant 
experience in molecular cloning, protein production and X-ray crystallography. 
Additional background in NMR spectroscopy and enzymatic assay is considered a 
plus but not essential. The expected starting date is September 1st,2012 or 
sooner. Interested applicants should send curriculum vitae, a summary of past 
research experience and accomplishments, and contact information of two or 
three references to Jikui Song, Ph.D. Department of Biochemistry, University of 
California, Riverside, CA 92521 (Email: songlab...@gmail.com). 
As one of the major research universities in California, UCR houses 
well-equipped X-ray and NMR facilities. Riverside is located near to big cities 
such as Los Angeles, San Diego and Las Vegas. Such an environment allows one to 
have a good balance of life and science here.
More information can be found in 
http://biochemistry.ucr.edu/faculty/song/song.html.

---
Jikui Song, PhD
Department of Biochemistry
University of California, Riverside

[ccp4bb] Post-doctoral position available

[Meng-Chiao Ho]

Dear All,

The Ho lab at the Institute of Biological Chemistry of Academia Sinca in Taiwan 
seeks to recruit a motivated structural biologist at post-doctoral level with 
interest in structure and activity studies of pharmaceutically important 
enzymes.

Applicant should have a strong background in protein expression and 
purification. Some experience in protein crystallography is required. Candidate 
possessing experience in high-throughput protein production, protein thermal 
assay, or fragment-based screening are preferred. This position provides the 
opportunity or broad training in protein expression, crystallization, small 
anlge X-ray scattering, enzymology and protein-protein interaction.

Applicants should submit the curriculum vitae and the names and contact 
information of three professional references via email to: 
sbddintai...@gmail.com

For more information about the lab, please visit 
http://www.ibc.sinica.edu.tw/ho 

We are looking forward to receiving your application!

Joseph Ho

[ccp4bb] Post-doctoral position available

[Petri Kursula]

A post-doctoral position is available in the group of Dr. Petri Kursula, to 
study structure-function relationships in proteins specifically expressed in 
the myelin sheath. The targets of the project are membrane-associated myelin 
proteins, which have functions e.g. in the interactions between the myelin 
sheath and the axon, and in the compaction of the multilayered myelin membrane. 
We are specifically interested in the structures of these proteins and their 
complexes, their interactions with macromolecular and small-molecule ligands, 
as well as membranes. 

The project will involve e.g. large-scale recombinant expression of myelin 
proteins or domains thereof, their biophysical characterization, X-ray 
crystallography and other structural biology methods, as well as more specific 
methods, such as oriented CD spectroscopy and other membrane interaction 
assays. 

The ideal candidate will have:
- PhD in biochemistry/structural biology or a closely related field
- a good publication record
- significant hands-on experience in recombinant protein expression and 
large-scale purification
- a genuine interest in structural biology
- fluency in English
- experience in supervising junior colleagues

Previous work with extracellular domains or peripheral membrane proteins will 
be considered an asset, as will experience in versatile structural biology and 
biophysical methods.

The position is initially available for 1 year, with possibilities for 
extension for up to 3 years. The selected candidate will be affiliated with the 
Department of Biochemistry, University of Oulu, Finland, but a large part of 
the work is expected to be carried out at the Centre for Structural Systems 
Biology (CSSB-HZI), on-site the DESY synchrotron campus, Hamburg. 

More information about our group can be found at www.biochem.oulu.fi/kursula.

To apply, please send your cv, including list of publications, plus the names 
and email addresses of 2-3 referees by email to petri.kurs...@oulu.fi. The 
application deadline is July 31st, 2011.


---
Petri Kursula, PhD
Group Leader and Docent of Neurobiochemistry (University of Oulu, Finland)
Visiting Scientist (CSSB-HZI, DESY, Hamburg, Germany)
www.biochem.oulu.fi/kursula
www.desy.de/~petri
petri.kurs...@oulu.fi
petri.kurs...@desy.de
---

[ccp4bb] Post-Doctoral position available at Griffith University, Australia

[Helen Blanchard]

 A postdoctoral position is available in the
laboratory of A/Prof Helen Blanchard at the Institute for Glycomics, Griffith
University, Gold Coast, Queensland, Australia. Research at Griffith Universitys Institute for Glycomics is focused on the study of the glycans (sugars)
and glycan-binding proteins in various biological systems, and the design of
novel drugs and vaccines. The Institute for
Glycomics collaborates with leading scientists
around the globe to build a critical mass around carbohydrate-based research in
areas of clinically significant diseases.The postdoctoral research will involve the
elucidation and characterisation of protein complexes as part of structure based inhibitor design programs. The main targets being the
carbohydrate recognizing proteins of rotavirus, metapneumovirus and galectins.Experience in macromolecular crystallography and
protein-inhibitor interaction analysis is required and a strong interest in structure
based drug design. 

Experience in molecular biology and biochemistry
is desirable.Further details about the facilities and
expertise of the Institute for Glycomics can be found at http://www.griffith.edu.au/glycomics

Interested candidates should send their CV
to Helen Blanchard (h.blanch...@griffith.edu.au)


Helen Blanchard  Ph.D, FRSCAssociate ProfessorResearch Leader, Institute for GlycomicsGriffith University, Gold Coast CampusQueensland 4222Australia Email:  h.blanch...@griffith.edu.au Telephone:  +61 7 555 27023   Fax:  +61 7 555 28098  http://www.griffith.edu.au/glycomics  

[ccp4bb] Post-Doctoral position available at Queen's University, Kingston, Ontario, Canada

[John Allingham]

Subject:
Post-Doctoral position available at Queen's University, Kingston,  
Ontario, Canada


Project Description: A postdoctoral position is available immediately  
for structure-function studies of cytoskeletal motor proteins in human  
and agricultural fungal pathogens in the Department of Biochemistry at  
Queen's University. Projects investigating the structural basis of  
secondary metabolite biosynthesis and biofilm generation in these  
organisms are also available. For these studies, combined approaches  
in molecular biology, biochemistry, biophysics and X-ray  
crystallography are employed. The laboratory is fully equipped with  
all the required infrastructure and in-house X-ray crystallography  
instrumentation. We also have full access to several synchrotron  
beamlines in APS, CHESS, and NSLS.


Qualifications:
The position requires a Ph.D. degree with experience in protein  
purification, crystallization and successful structure determination.


How to Apply:
Interested candidates should send a CV and names and contact  
information for 3 references by email to:


John S. Allingham (Email: allin...@queensu.ca)
Assistant Professor
Tier 2 Canada Research Chair in Structural Biology
Department of Biochemistry
Botterell Hall
Queen's University
18 Stuart St., Rm 641
Kingston, ON
K7L 3N6 Canada

Phone: (613) 533-3137
Fax: (613) 533-2022



For more information, please visit http://meds.queensu.ca/biochem/biochemistry_faculty?id=36 

[ccp4bb] Post-Doctoral position available at Karolinska Institutet, Sweden

[Agnes Rinaldo-Matthis]

Post-Doctoral position available at Karolinska Institutet, Sweden

Project description:

A post-doctoral position is available at the Department of Medical Biochemistry 
and Biophysics (MBB), Karolinska Institutet, Stockholm. The project deals 
primarily with over-expression, purification, crystallization and structure 
determination of human enzymes involved in the generation of lipid mediators of 
inflammation. The successful candidate will join a multi-disciplinary research 
team and the position represents an excellent opportunity for a postdoctoral 
scientist to develop his/her expertise as well as broaden his/her experience.

Qualifications:

We are seeking an experienced crystallographer with a Ph.D. in protein 
crystallography. A proven track record of multiple successful structure 
determinations is required.  Previous experience, apart from crystallography, 
with protein expression, purification and enzyme kinetics, is desirable.  The 
candidate should be self-motivated, have interpersonal communication skills and 
ability to interact effectively and work productively in a team.

How to Apply:

Interested candidates should send a CV and letters of reference by either email 
to agnes.rinaldo-matt...@ki.semailto:agnes.rinaldo-matt...@ki.se or by normal 
post to Agnes Rinaldo-Matthis, MBB, Karolinska Institutet, Scheeles väg 2, 
S-171 77 Stockholm, Sweden.

[ccp4bb] Post-Doctoral Position Available

[Jean Cavarelli]

POST-DOCTORAL POSITION 

DATE OF AVAILABILITY: starting as soon as possible, for 2 years.

TITLE:  structural biology of complexes involved in tumor reversion. 

POSITION: the position is opened in the department of Integrated Structural 
biology, IGBMC, located in Strasbourg-Illkirch (France) in the team of Jean 
Cavarelli (Structural biology of epigenetic targets).

JOB DESCRIPTION: 
Our main scientific goal is to identify, characterize and analyze at the 
structural level, functional complexes involving selected protein targets to 
study the molecular switches and signals that induce biological activity.  The 
aim of the proposed research project is to better understand the biology of a 
multi-functional protein which is strongly involved in the process of tumor 
reversion. The purpose of the structural study is to decipher at the molecular 
level the interactions between this protein and different biological partners. 
The structural work is part of a collaborative project involving three groups.


JOB REQUIREMENTS: 

The applicant should hold a PhD in structural biology and must have a strong 
background in protein biochemistry (cloning, purification and 
biochemical/biophysical characterization).  Experience in X-ray crystallography 
would be an advantage.
 

SCIENTIFIC ENVIRONMENT: 

IGBMC is one of the leading European centers of biomedical research, devoted to 
the study of higher eukaryotic genomes and to the control of genetic expression 
as well as the analysis of the function of genes and proteins. The department 
of Integrated Structural Biology aims at understanding the mechanisms of 
cellular processes by correlating the structural and the functional properties 
of their macromolecular components. The post-doc will benefit from a technical 
environment including, the Structural Biology and Genomics Technology (SBGT) 
platform. The SBGT platform includes offers access to state of the art 
equipments for robotized cloning and expression tests, large scale prokaryotic 
and eukaryotic sample production and purification facilities, biophysical 
characterization, high-throughput crystallization screening, electron 
microscopy, X-ray and NMR facilities.

TO APPLY: please send a CV and the names of two referees to Pr. Jean Cavarelli: 
c...@igbmc.fr

[ccp4bb] Post doctoral position available

[Edward Lowe]

Posted on behalf of Dr. Mark Howarth:


Postdoctoral Fellowship available.
Super-strong protein-ligand interactions: Design, Structural investigation
and Application in Bionanotechnology

The general theme of our research is to develop new biological and chemical
approaches for cellular imaging and disease diagnosis. The interaction of
streptavidin with biotin is one of the strongest non-covalent interactions
in nature. Streptavidin is a ubiquitous tool in molecular biology, as well
as showing success in cancer clinical trials. We have previously made two
advances in streptavidin, generating a monovalent version and a mutant with
10-fold more stable biotin binding. These variants have enabled new
possibilities, such as for single-molecule imaging of receptor traffic,
ultra-sensitive detection, and testing power-generation by DNA pumps. We are
seeking to appoint a postdoc to design variants of streptavidin with new
assembly and ligand-binding properties, to apply these in bionanotechnology,
and to use biophysical approaches (including crystallography) to gain
insight into the fundamental limits of the strength of protein:ligand
binding. Streptavidin typically crystallizes quickly, to produce crystals
diffracting to high resolution. Experience in crystallography is helpful but
training can be provided. A strong background in molecular biology and
recombinant protein expression is required. The appointment will be for 2
years, with possible extension for 1 further year. For initial application
please e-mail a CV, including contact details for 3 referees, to
mark.howa...@bioch.ox.ac.uk

[ccp4bb] Post-doctoral position available in New York

[Hernando Sosa]

A post-doctoral position to study cystoskeletal macromolecular 
assemblies using cryo-electron microscopy is available in our 
laboratory. For this position the ideal candidate would be interested in 
solving problems related to protein structure and function and have 
experience in molecular electron microscopy. Candidates with experience 
in protein expression and purification with a strong interest in 
structural biology will also be considered.


 In our lab we employ a variety of approaches such as site-directed 
mutagenesis, cryo-electron microscopy and single molecule fluorescence 
microscopy to investigate cystoskeletal motors at the molecular level 
(e. g. see: Tan et al., Structure 16: 1732-9, 2008; Asenjo  Sosa PNAS 
106: 5657-62, 2009).We have access to state of the art facilities for 
cryo-em work located at the Albert Einstein College of Medicine and at 
the New York Structural Biology Center that include several cryo-em 
microscopes (Tecnai 20, Tecnai G2 F20, JEOL 1230, JEOL 2100F, JEOL 
3200FSC). Our laboratory is located in the Albert Einstein College of 
medicine in New York City, which offers excellent opportunities for 
scientific interaction within the college and with many other scientific 
institutions in the New York area.Interested candidates please send a 
letter (or email), CV and reference names to:


 Hernando Sosa
Dept. of Physiology and Biophysics
Albert Einstein College of Medicine
1300 Morris Park Av.
Bronx NY 10461
Office: 718-430-3456
Lab: 718-430-3451
FAX: 718-430-8819
Email: hernando.s...@einstein.yu.edu

The Albert Einstein College of Medicine is an equal opportunity employer.

--
---
Hernando Sosa
Dept. of Physiology and Biophysics
Albert Einstein College of Medicine
1300 Morris Park Av.
Bronx NY 10461
phone   (718) 430-3456
FAX (718) 430-8819
email   hernando.s...@einstein.yu.edu
---




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[ccp4bb] Post-doctoral position available at IBS - please do not reply to me !

[Vellieux Frederic]

POST-DOCTORAL POSITION

DATE OF AVAILABILITY : starting as soon as possible, for 2 years (ANR 
contract).


TITLE : purification and crystallization of ABC transporters

POSITION: the position is opened at the Institute for Structural Biology 
(IBS) in Grenoble in the team of Jean-Michel Jault and will be carried 
out in the framework of a collaborative project between chemists and 
biologists, both in Lyon (IBCP and UCB) and in Grenoble (IBS and UJF) 
with funding from an ANR grant.


JOB DESCRIPTION: Multi-Drug Resistance (MDR) is an increasingly 
challenging problem in the biomedical field and is widespread from 
tumour cells to microbes. In bacteria, resistance to multiple 
antibiotics is often associated with the presence of MDR pumps and 
several of these belong to the largest superfamily of membrane proteins, 
the ABC (“ATP-Binding Cassette”) transporters, which include some human 
members whose dysfunction is involved in severe pathologies (cancer, 
cystic fibrosis, adrenoleukodystrophy…). This project will focus on two 
bacterial ABC transporters that we routinely purify in high yields in 
their functional states, with the goal to crystallize them and solve 
their 3-D structure, using both classical detergents and newly 
synthesized ones.


JOB REQUIREMENTS: the applicant should hold a PhD in Biochemistry and 
have a strong background in protein biochemistry (purification and 
biochemical/biophysical characterisation) and in protein 
crystallography. Additional knowledge in membrane proteins will be 
appreciated.


SCIENTIFIC ENVIRONMENT: the Institut de Biologie Structurale (Institute 
for Structural Biology) is located in the Grenoble “Polygone 
Scientifique” area, in the close vicinity of the EMBL outstation, ESRF 
and ILL, i.e. it is one of the most renowned scientific area in France 
for biological research. At the IBS, the post-doc will benefit from a 
technical environment devoted to purification, characterization and 
crystallization of membrane proteins (MP3, PAOL and high throughput 
membrane protein crystallization platforms), as well as the scientific 
expertise associated with these. More information available from 
http://www.psb-grenoble.eu/ and http://www.ibs.fr/?lang=en


TO APPLY: please send a CV and the names of two referees to Jean-Michel 
Jault : jean-michel.ja...@ibs.fr

[ccp4bb] Post-doctoral position available June 1st at UMDNJ

[Narayanan Ramasubbu]

A postdoc position is immediately available in my laboratory
at the Oral Biology Department, UMDNJ. The post-doc will work on the elucidation of 
structure of enzymes involved in modifying A. actinomycetemconitans biofilms. 
Crystals of two such enzymes are available.
Experience in expression and purification using his tag is essential. 
Additional experience in yeast expression is desirable. A highly motivated

individual with at least one year experience in structural biology and protein
biochemistry who is a team player is sought. This position is for one year with 
the potential for additional years depending upon funding.

Please send your CV and names of three
references to Dr. N. Ramasubbu (ramas...@umdnj.edu). 


Subbu

[ccp4bb] Post-doctoral position available with Phaser team

[Randy J. Read]

We are looking to expand the team developing our program Phaser, for use
within both the CCP4 and Phenix packages.  Our goals include expanding the
functionality to new phasing experiments (in addition to the options for
molecular replacement and SAD that exist in the current version), and
enhancing the automation of Phaser runs.

The ideal applicant would be someone with experience solving macromolecular
crystal structures and programming in both C++ and Python.  However, if you
only have experience in one of those areas, but a strong desire to expand
your skills, then you might be the right person.

If you're interested, please look at the formal advertisement
(http://www.admin.cam.ac.uk/offices/hr/jobs/vacancies.cgi?job=4017), and
submit an application as described there.  I'm also happy to answer any
informal enquiries.  The position is funded by a grant from the Wellcome
Trust, which extends to May 2013.

Please note that the closing date for applications is 2 October 2008.

Regards,

Randy Read