Postdoctoral position in ion channel mechanism with cryo-EM available in the laboratory of Crina Nimigean at Weill Cornell Medical College in New York City There is an availability in the laboratory of Crina Nimigean for an enthusiastic postdoc who is interested in the molecular workings of ion channels. The successful candidate will investigate ion channel structure and mechanism with single-particle cryo-EM and functional assays such as single-channel recordings, stopped-flow fluorescence, etc. The work in the lab is generally geared towards developing a mechanistic understanding of ion channels using functional and structural techniques (see two recent articles below). We are located at the Weill Cornell Medical College on the upper east side of Manhattan, within the vibrant and international tri-Institutional scientific community, which is comprised of Rockefeller University, Memorial Sloan Kettering and Weill Cornell. We have screening electron microscopes on site, within the newly established cryo-EM core facility at Cornell, and we have full access to state-of-the-art Titan Krios microscopes for high resolution data collection at the New York Structural Biology Center and other cost-based facilities. Qualifications and experience: Candidates should hold a Ph.D. and have a solid background in biophysics, ion channel electrophysiology, and/or protein biochemistry. Experience with cryo-EM is not required but welcome. Excellent verbal and written English communication skills, and ability to work in close collaboration with other researchers are required. Qualified applicants should send a cover letter, CV, and the names of three references by email to Crina Nimigean at crn2...@med.cornell.edu<mailto:crn2...@med.cornell.edu>.
Rheinberger J., Gao X., Schmidpeter P.A.M., Nimigean C.M. (2018) Ligand discrimination and gating in CNG channels from apo and partial agonist-bound cryo-EM structures, eLife doi: 10.7554/eLife.39775 Marchesi A., Gao X., Adaixo R.., Rheinberger J., Stahlberg H., Nimigean C.M., Scheuring S. (2018) An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel, Nature communications, doi: 10.1038/s41467-018-06414-8 ----------------------------------------------------- Crina Nimigean, Ph.D. Weill Cornell Medical College Associate Professor of Physiology and Biophysics in Anesthesiology Associate Professor of Biochemistry http://physiology.med.cornell.edu/faculty/nimigean/lab/ Department of Anesthesiology, Box 124 525 East 68th Street, Room A-1050 New York, NY 10065 Phone: (212) 746 5947 Fax: (212) 746 4879 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
