Job Summary ModeX Therapeutics is seeking a highlytalented and motivated research scientist with expertise in the field ofantibody engineering to join our team. The candidate will be part of an established multidisciplinary teamadvancing discovery efforts on our earlier-stage programs as well as movingnovel therapeutic antibodies into clinic. The individual will work in the state-of-the-art laboratory and isresponsible for experimental design, execution, data analysis, and recordkeeping and presentation. This is anexciting opportunity to be part of a cross-functional team and contribute tothe development of cutting-edge biotherapeutics in a fast-paced, rapidlygrowing biotech company with a bold vision.
Company ModeX Therapeutics, a subsidiary of OPKO Health, is a biotech startup basedin Massachusetts dedicated to the concept of modulating multiple diseasetargets with innovative multi-targeting strategies. It was founded by Dr. EliasZerhouni and Dr. Gary J. Nabel in 2020 with a team of scientists with proventrack record from early research to clinical development, regulatory approvals,and commercialization. ModeX is pursuing the development of novelimmune-oncology therapeutics for cancers and biotherapeutics against infectiousdisease. Major responsibilities · Interact closely and be part ofinterdisciplinary biologics research teams to drive the discovery of innovative therapeutic antibodies and theoptimization of their biological and biophysical properties. · Contribute to ModeX’s multi-targetingstrategy through antibody discovery campaigns and structure-based antibodydesign. · Develop andimplement high-throughput antibody expression and purification platforms. Enhanceoptimization of workflows · Immunogen immunizationstrategy design. Single B cell sorting and/or screening technologies. · Interpret results and present/communicatewith cross-functional colleagues for successful execution and completion ofprojects. · Stayscientifically current and contribute to the implementation of new technologyand instrumentation. · Ensure effective,high-quality, timely and appropriate documentation in electronic laboratorynotebooks. Qualifications · PhD in biochemistry, structurebiology or other life science disciplines with 3+ years of relevant experience antibodyengineering. · Hands-on experience inantibody generation and optimization (affinity modulation, humanization, PTMmitigation, etc.) in an industrial setting with strong track record of deliveryof high quality antibodies. · Expertise in immunology,B cell biology, cloning, next gen. sequencing and data analysis. Hands on experiencein hybridoma/B cell cloning, automation, Elisa, BLI/SPR, and FACS. · Knowledge in proteinengineering using direct evolution methods such as yeast surface and mammaliandisplay. · Knowledge in antibodystructure and experience in structure-based protein engineering is preferred. · Computer skills,including large dataset analysis and basic scripting · Excellent written andoral communication, organization, and data analysis skills. Outstanding troubleshooting and problem-solvingskills. · Highly adaptable to afast-paced work environment and capable to work both independently andcollaboratively within project teams. To apply, please send cover letter and CVto ronnie....@modextx.com and care...@modextx.com ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
