[ccp4bb] mutagenesis based on ligand-bound crystal structures

2012-02-07 Thread Chris Ulens

Dear colleagues,
I am looking for a few example studies in which a complete mutagenesis  
of all residue-ligand interactions has been conducted to evaluate the  
energetic contributions of each individual interaction.

Thank you.
Best regards.
-Chris

---
Chris Ulens, Ph.D.
Lab of Structural Neurobiology
Department of Cellular and Molecular Medicine
Campus Gasthuisberg, ON1
Herestraat 49, PB 601
B-3000 Leuven
Belgium
e   chris.ul...@med.kuleuven.be
t+32 16 330689
f+32 16 345699
w   http://www.xtal.be


Re: [ccp4bb] mutagenesis based on ligand-bound crystal structures

2012-02-07 Thread Savvas Savvides
Dear Chris
A whole series of studies from the early to late 90's did his for the growth 
hormone-GHR interaction. 
Papers by Pearce, Cunningham, Clackson and Wells come to mind. 
Also a recent study on the IL13-IL13R interaction by Lupardus et al has covered 
most of the interaction epitope. 

Best regards
Savvas

On 07 Feb 2012, at 10:16, Chris Ulens chris.ul...@med.kuleuven.be wrote:

 Dear colleagues,
 I am looking for a few example studies in which a complete mutagenesis of all 
 residue-ligand interactions has been conducted to evaluate the energetic 
 contributions of each individual interaction.
 Thank you.
 Best regards.
 -Chris
 
 ---
 Chris Ulens, Ph.D.
 Lab of Structural Neurobiology
 Department of Cellular and Molecular Medicine
 Campus Gasthuisberg, ON1
 Herestraat 49, PB 601
 B-3000 Leuven
 Belgium
 e   chris.ul...@med.kuleuven.be
 t+32 16 330689
 f+32 16 345699
 w   http://www.xtal.be