You can certainly adjust the two values as needed for your particular 
environment.  Also check in your universe_wsgi.ini for:

set_metadata_externally = True

Something else you might want to consider, and what we do to handle the load on 
the server at http://usegalaxy.org, is starting more instances to balance the 
load.  For reference, our settings for pool_size and max_overflow are 10 and 
20, respectively.

See https://bitbucket.org/galaxy/galaxy-central/wiki/Config/ProductionServer 
for a good reference with more details on setting up a high performance galaxy 
server in a production environment suitable for multiple users.

-Dannon


On Apr 21, 2011, at 1:47 PM, Liisa Koski wrote:

> Hi, 
> We are running many NGS workflows at the same time on our local instance of 
> Galaxy. They are crashing with the following error 
> 
>  Error - <class 'sqlalchemy.exc.TimeoutError'>: QueuePool limit of size 5 
> overflow 10 reached, connection timed out, timeout 30 
> 
> In  the universe_wsgi.ini we made the following adjustments: 
> 
> # If the server logs errors about not having enough database pool 
> connections, 
> # you will want to increase these values, or consider running more Galaxy 
> # processes. 
> database_engine_option_pool_size = 50   # this used to be 5 
> database_engine_option_max_overflow = 100 # this used to be 100 
> 
> 
> Those numbers were pulled out of a hat so I wanted to make sure what we were 
> doing was correct. Is there a limit on the values? It doesn't appear to be 
> crashing anymore but I still want to make sure. 
> 
> Thanks, 
> Liisa___________________________________________________________
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