Re: [Histonet] V600E

[Gudrun Lang via Histonet]

This is an mutationspecific antibody against BRAF. And the mutation detected is 
called p.V600E. The exchange of an nucleotid in the
DNA (codon 600) leads to an tranformed and always activated BRAF-protein, that 
is sensitive to an thyrosinkinase-inhibitor as an eg.
Melanoma therapy. As far as I remember it was sold by Novus Biological before 
Roche-Ventana had it. The clone is VE1.

Gudrun

-Ursprüngliche Nachricht-
Von: Normington Lacy via Histonet [mailto:histonet@lists.utsouthwestern.edu] 
Gesendet: Mittwoch, 6. Juni 2018 16:43
An: Laurie Colbert; 'histonet@lists.utsouthwestern.edu'
Cc: jtouchst...@pathmdlabs.com
Betreff: Re: [Histonet] V600E

I am thinking this might be BRAF, clone V600E.  We get ours from Ventana Roche.

Lacy Normington
UW Health 
Madison, WI


-Original Message-
From: Laurie Colbert via Histonet [mailto:histonet@lists.utsouthwestern.edu] 
Sent: Wednesday, June 06, 2018 8:50 AM
To: histonet@lists.utsouthwestern.edu
Cc: jtouchst...@pathmdlabs.com
Subject: [Histonet] V600E

WARNING: This email appears to have originated outside of the UW Health email 
system.
DO NOT CLICK on links or attachments unless you recognize the sender and know 
the content is safe.




Can anyone tell me about the V600E antibody?  Our pathologist wants to add it 
to our menu of IHC stains, and I've never heard of it.
Sources?

Thanks,
Laurie Redmond
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Re: [Histonet] V600E

[Normington Lacy via Histonet]

I am thinking this might be BRAF, clone V600E.  We get ours from Ventana Roche.

Lacy Normington
UW Health 
Madison, WI


-Original Message-
From: Laurie Colbert via Histonet [mailto:histonet@lists.utsouthwestern.edu] 
Sent: Wednesday, June 06, 2018 8:50 AM
To: histonet@lists.utsouthwestern.edu
Cc: jtouchst...@pathmdlabs.com
Subject: [Histonet] V600E

WARNING: This email appears to have originated outside of the UW Health email 
system.
DO NOT CLICK on links or attachments unless you recognize the sender and know 
the content is safe.




Can anyone tell me about the V600E antibody?  Our pathologist wants to add it 
to our menu of IHC stains, and I've never heard of it.  Sources?

Thanks,
Laurie Redmond
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Re: [Histonet] V600E

[Charles Riley via Histonet]

Our paths just asked me to add this antibody also. Ventana-Roche is one
source but we don't deal with them because of pricing issues. I believe we
are purchasing from Sigma Aldrich instead. I put the info my pathologist
provided in the email below

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On Wed, Jun 6, 2018 at 9:50 AM, Laurie Colbert via Histonet <
histonet@lists.utsouthwestern.edu> wrote:

> Can anyone tell me about the V600E antibody?  Our pathologist wants to add
> it to our menu of IHC stains, and I've never heard of it.  Sources?
>
> Thanks,
> Laurie Redmond
> ___
> Histonet mailing list
> Histonet@lists.utsouthwestern.edu
> http://lists.utsouthwestern.edu/mailman/listinfo/histonet
>



-- 

Charles Riley BS  HT, HTL(ASCP)CM

Histopathology Coordinator/ Mohs
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