Re: [MBZ] OT: Vaccine tech

2020-12-22 Thread Clay Monroe via Mercedes
Socialized will just create a bog of shoddy treatment centers to run out the 
meter on coverage.  Better to have actuary pencil out numbers and then cause 
the expensive treatments mandated as riders to the main policy.  You get the 
basic level of OsamasCare ACA lead, silver, gold.  Pick the disease you are 
will to bet you will get, and pay for each malady.  Much like home insurance 
and flood/earthquake/wildfire/BLM movements.   Be able to cover your heart, 
lungs, brain, for cancer, pneumonia, government incompetence and over reach.  
One added line item at a time.  Think of it as towing insurance for your butt 
or something.

Then you will see changes in how the health system is run.  No money in chasing 
illness that has no profits.  Which makes it devolve onto well meaning 
billionaire to just whip out a check book to cure cancer because it killed his 
mama, or brain cancer, because he has sold people on home delivery of cheap 
garbage chinese crap.  Got to be brain damaged to fall for that spiel.

Clay


inter urinas et faeces nascimur

> On Dec 22, 2020, at 7:57 AM, Andrew Strasfogel via Mercedes 
>  wrote:
> 
> Socialized medicine will take the profit away from cancer treatment and we
> will instantly get cures.

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Re: [MBZ] OT: Vaccine tech

2020-12-22 Thread Floyd Thursby via Mercedes
There will never be a cure for "cancer" because "cancer" is a term for a 
variety of diseases, each of which is different.  The nature of most of 
them is that they can never be "cured" but can be managed, or put off, 
at least for now.


Maybe with more research and drug development there will be "cures" for 
more of these diseases based on biological/genetic mechanisms, etc.  One 
hopes.  Until then, the profit motive is what keeps development going, 
mostly.


But there is also the testing, clinical trials and such, that needs to 
be done to minimize risks (including financial and lawyers and FDA regs 
and that kind of thing) so yeah it costs a lot of money.  Look at the 
howling about the Covids vax not following all this lengthy protocol...


--FT

On 12/22/20 8:15 AM, Kaleb Striplin via Mercedes wrote:

There will never be a cure for cancer. There is way too much money in it.


--
--FT


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Re: [MBZ] OT: Vaccine tech

2020-12-22 Thread Andrew Strasfogel via Mercedes
I was trying to be facetious.

On Tue, Dec 22, 2020 at 12:03 PM Mitch Haley via Mercedes <
mercedes@okiebenz.com> wrote:

> On 2020-12-22 08:15, Kaleb Striplin via Mercedes wrote:
> > There will never be a cure for cancer. There is way too much money in
> > it.
>
> You mean like the NAACP won't allow racism to die, or the NRA never
> tries to get rid of gun control?
>
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Re: [MBZ] OT: Vaccine tech

2020-12-22 Thread Mitch Haley via Mercedes

On 2020-12-22 08:15, Kaleb Striplin via Mercedes wrote:
There will never be a cure for cancer. There is way too much money in 
it.


You mean like the NAACP won't allow racism to die, or the NRA never 
tries to get rid of gun control?


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Re: [MBZ] OT: Vaccine tech

2020-12-22 Thread Andrew Strasfogel via Mercedes
Socialized medicine will take the profit away from cancer treatment and we
will instantly get cures.

On Tue, Dec 22, 2020 at 8:15 AM Kaleb Striplin via Mercedes <
mercedes@okiebenz.com> wrote:

> There will never be a cure for cancer. There is way too much money in it.
>
> Sent from my iPhone
>
> > On Dec 21, 2020, at 9:21 PM, Allan Streib via Mercedes <
> mercedes@okiebenz.com> wrote:
> >
> > Mitch Haley via Mercedes  writes:
> >
> >> It really only takes a few days of work to decide on the sub
> >> sequence from the viral genome to build the mRNA that will cause the
> >> desired antigen.
> >
> > Yes the COVID-19 vaccine was developed in two days once they had the
> > genetic sequence from the Chinese. All the rest of the time has been
> > developing and performing the clinical trials and analyzing the results.
> >
> >
> https://theness.com/neurologicablog/index.php/it-took-two-days-to-develop-modernas-vaccine/
> >
> > mRNA technology has also shown some promising early results in
> > developing a cancer "vaccine" that can be tailored to the individual and
> > particular cancer being treated.
> >
> > Allan
> >
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> >
>
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Re: [MBZ] OT: Vaccine tech

2020-12-22 Thread Kaleb Striplin via Mercedes
There will never be a cure for cancer. There is way too much money in it. 

Sent from my iPhone

> On Dec 21, 2020, at 9:21 PM, Allan Streib via Mercedes 
>  wrote:
> 
> Mitch Haley via Mercedes  writes:
> 
>> It really only takes a few days of work to decide on the sub 
>> sequence from the viral genome to build the mRNA that will cause the 
>> desired antigen.
> 
> Yes the COVID-19 vaccine was developed in two days once they had the
> genetic sequence from the Chinese. All the rest of the time has been
> developing and performing the clinical trials and analyzing the results.
> 
> https://theness.com/neurologicablog/index.php/it-took-two-days-to-develop-modernas-vaccine/
> 
> mRNA technology has also shown some promising early results in
> developing a cancer "vaccine" that can be tailored to the individual and
> particular cancer being treated.
> 
> Allan
> 
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> 
> To Unsubscribe or change delivery options go to:
> http://mail.okiebenz.com/mailman/listinfo/mercedes_okiebenz.com
> 


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Re: [MBZ] OT: Vaccine tech

2020-12-21 Thread Allan Streib via Mercedes
Mitch Haley via Mercedes  writes:

> It really only takes a few days of work to decide on the sub 
> sequence from the viral genome to build the mRNA that will cause the 
> desired antigen.

Yes the COVID-19 vaccine was developed in two days once they had the
genetic sequence from the Chinese. All the rest of the time has been
developing and performing the clinical trials and analyzing the results.

https://theness.com/neurologicablog/index.php/it-took-two-days-to-develop-modernas-vaccine/

mRNA technology has also shown some promising early results in
developing a cancer "vaccine" that can be tailored to the individual and
particular cancer being treated.

Allan

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Re: [MBZ] OT: Vaccine tech

2020-12-21 Thread Buggered Benzmail via Mercedes
My two friends could go into excruciating detail on all that. But what little I 
have understood of what they have told seems to track with that. 

--FT
Sent from iPhone

> On Dec 21, 2020, at 6:09 PM, Mitch Haley via Mercedes  
> wrote:
> 

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[MBZ] OT: Vaccine tech

2020-12-21 Thread Mitch Haley via Mercedes
Quoting as found, perhaps some here will have the knowledge base to 
confirm or refute:


mRNA as a process is well understood and not new. mRNA as a mode of 
immunogenic antigen expression is cleaner than previous vaccine tech.


It may seemed rushed, but it wasn't in terms of creating the vaccine. 
Lots of work was already done on SARS-CoV-1 and MERS. Unlike previous 
vaccines, this one was made in the modern era where the entire viral 
genome was fully genetically sequenced and sent to labs world wide via 
email in January. No other vaccine push in history has had so many labs, 
so many companies, and so much effort and resources dumped into it 
putting everything else on the back burner. There are FIFTY EIGHT 
vaccines for COVID in various stages of testing! The mRNA vaccines are 
out first because they take the least effort to get right and put in 
testing. It really only takes a few days of work to decide on the sub 
sequence from the viral genome to build the mRNA that will cause the 
desired antigen. It is actually much simpler to do this than older 
vaccine development methods. Phase I/II/III testing looks like other 
vaccines, except more expansive. The only difference is the EUA during 
phase III after excellent studies with ongoing results showing great 
efficacy and safety were evaluated in the setting of a pandemic.


mRNA vaccines have been in the pipeline for 30 years.

The limit on the technology has always been the molecule stability 
(exonuclease and endonuclease degradation of RNA) and the ability to 
package it in a way the gets inside a cell (delivery).


The former is addressed by modifying the phosphodiester linkage (the 
means of linking one nucleoside to the next) to a phosphorothioate 
linkage (Sulfur replacing one of the Oxygens) that is poorly recognized 
by nuclease enzymes, and it turns out mRNA is more stable than 
previously thought. The latter by encapsulation or association of the 
mRNA with lipid nanoparticles.


There were mRNA vaccines developed but not needed so they weren't pushed 
further. mRNA cancer treatments did go through trials and they were 
safe, just not effective enough because it was before the tech we have 
now.


Luckily, now we have good safety and efficacy data on these mRNA 
vaccines.


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