Re: [NMusers] Re: Random number generation

[Sebastien Bihorel]

ERRATUM: 
runif.f90: 
FUNCTION FUNCA(X,X1,X2) 
USE SIZES, ONLY: DPSIZE 
REAL(KIND=DPSIZE) :: X,X1,X2,FUNCA 
FUNCA = RAND() 
RETURN 
END 


From: "Sebastien Bihorel"  
To: "Tingjie Guo"  
Cc: nmusers@globomaxnm.com 
Sent: Monday, June 3, 2019 4:54:46 PM 
Subject: [NMusers] Re: Random number generation 


Thanks Tingjie for your suggestion 

Unfortunately, as is, the suggested code is rejected by NONMEM 7.3 if used in 
$ERROR. Some additional setup calls might be required. 

An (admittedly heavy-handed) alternative that actually works is to create and 
import a fortran routine (see NONMEM help topic about FUNCA, or VECTRA). 

runif.f90: 
FUNCTION FUNCA(X,X1,X2) 
USE SIZES, ONLY: DPSIZE 
REAL(KIND=DPSIZE) :: X,X1,X2,FUNCA 
FUNCB = RAND() 
RETURN 
END 

Control stream: 
... 
$SUBROUTINES ADVAN_ TRANS_ OTHER=runif.f90 
... 
$ERROR 
VECTRA(1) = 0 
VECTRA(2) = 0 
VECTRA(3) = 0 

RND = FUNCA(VECTRA) 
... 


From: "Tingjie Guo"  
To: "Sebastien Bihorel" , 
nmusers@globomaxnm.com 
Sent: Monday, June 3, 2019 12:58:56 PM 
Subject: Re: Random number generation 

Hi Sebastien, 

As far as I know, you could write verbatim code to generate random numbers 
during estimation. E.g: 

$PK|$DES|$ERROR 
RAN = any value ; initialization 
"RAN = RAND(0) ; start verbatim code 

A random number between 0 and 1 from uniform distribution will be assigned to 
RAN. This function is called for each record of your input data. I believe it's 
also possible to call it more/fewer times through checking ICALL. 

Warm regards, 
Tingjie 





From: owner-nmus...@globomaxnm.com  on behalf of 
Sebastien Bihorel  
Sent: Thursday, May 30, 2019 12:34 
To: nmusers@globomaxnm.com 
Subject: [NMusers] Random number generation 

Hi, 

Is it possible for NONMEM to generate a random number during an estimation run? 

Thank you 

Sebastien Bihorel 

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[Chao Chen]

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Clinical Pharmacology Modelling & Simulation
GlaxoSmithKline R&D


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