Hi, (*1*) When I proposed the notion of the isomorphism between cell language (or cellese for short) and the human language (or humanese) in 1997 [1, 2, 3], one of the most striking features of both languages that caught my attention was the phenomenon of double articulations, i.e., letters forming words (2nd articulation) and words forming sentences (1st articulation). In both languages, the second articulation (i.e., covalent bond in cellese) is much more difficult to alter than the first articulation (i.e., non-covalent bonds).. Interestingly, this is also true in quantum mechanics (see cosmese, or the *cosmic language*, in *Table 1*)
(*2*) The phenomena of double articulations in *humanese*, *cellese*, and *cosmese* (i.e., t*he means of communication between the Universe and its components, including Homo sapiens, and between its components*) are defined in the upper portion of Table 1. (*3*) The phenomenon of double articulation is semiotics (or logic) is not as clear as in the other cases, primarily because Peircean semiotics, as I understand it, is based on two kinds of signs -- 9 types and 10 classes -- without the third kind that is needed to complete the double articulations. For convenience, I designated this third kind with the symbol X in *Table 1. * It is possible that Peirce's writings mention something similar to or identical with X but I am ignorant of it. *Table 1*. The postulate that the principle of double articulation underlies all organizations in the Universe. Organization *Humanese* *Cellese* *Cosmese* *First Articulation* Words | | V Sentences 1D Structures | | V 3 D Structures Baryons | | V Molecules *Second Articulation* Letters | | V Words Molecules | | V 1 D Structures Quarks | | V Baryons *Force* * ‘Semantic’*** *‘Cell force’** *Strong and Electroweak forces* *Field of Study* *Linguistics* *Biology* *Physics/Chemistry* *Semiotics:* * 9 Sign Types -----------> 10 Sign Classes ----------------> X * * ('Elementary signs') ('Composite signs') ('Complex signs') * *ITR(Irreducible Triadic Relation)* * f g* * Cosmese -----------> Cellese ------------> Humanese* * | ^ | | | | |____________________________________|* * h* * f** = biogenesis* * g** = semiogenesis (?)* * h** = information flow* *Defined as the new kind of force in nature that is postulated to be responsible for organizing the physicochemical processes inside the cell so as to maintain life despite the destructive power of thermal motions, just as the strong force maintain the structure of the atomic nuclei despite the electrostatic repulsions among protons [5]. **Used here for the first time and defined as the 'force' that holds together the elements of a language (i.e., letters, words, sentences) so that they can signify or be meaningful, just as the strong force holds together nucleons (protons and neutrons) within atomic nuclei despite the electrostatic repulsion among protons. (*4*) It is interesting to note that *Semiotics* does not fit in nicely with the three special sciences of *linguistics*,* biology *and* physics* that occupy the three *columns* side by side in the upper portion of *Table 1* but instead resides in one of the *rows* in the table, indicating that semiotics is ORTHOGONAL to (or cannot be replaced by) special sciences. (*5*) Finally, the question naturally arises as to the possible relation among the four fields of inquiries -- *humanese*, *cellese*, *cosmese*, and *semiotics*. One possibility is is depicted in the lower portion of *Table 1*, suggesting that the principle of ITR (Irreducible Triadic Relation), the heart of Peircean semiotics, may provide the needed overarching theoretical framework for integrating and organizing these distinct disciplines. All the best. Sung Sungchul Ji, Ph.D. Associate Professor of Pharmacology and Toxicology Department of Pharmacology and Toxicology Ernest Mario School of Pharmacy Rutgers University Piscataway, N.J. 08855 732-445-4701 www.conformon.net Referecnes: [1] S. Ji (1997). Isomorphism between cell and human languages: molecular biological, bioinformatics and linguistic implications. *BioSystems* *44*: 17-39. PDF at http://www.conformon.net under Publications > Refereed Journal Articles. [2] S. Ji (1999). The Linguistics of DNA: Words, Sentences, Grammar, Phonetics, and Semantics. *Ann. N. Y. Acad. Sci*. *870: *411-41. PDF at http://www.conformon.net under Publications > Refereed Journal Articles. [3] Ji, S. (2001). Isomorphism between Cell and Human Languages: Micro- and Macrosemiotics. In: Semiotics 2000: “Sebeok’s Century” (S. Simpkins, and J. Deely, eds.). Legas, Ottawa, pp. 357-374. PDF at http://www.conformon.net under Publications > Proceedings. [4] S. Ji (2002). Microsemiotics of DNA. *Semiotica* *138*(1/4):15-42. PDF at http://www.conformon.net under Publications > Refereed Journal Articles. [5] S. Ji (1991). Biocybernetics: A Machine Theory of Biology, in *Molecular Theories of Cell Life and Death* (S. Ji, ed.), Rutgers University Press, New Brunswick, pp. 1-237.
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