Comment #9 on issue 2658 by trowb...@gmail.com: Something broke! (Error 500) http://code.google.com/p/reviewboard/issues/detail?id=2658
That looks like it's definitely a problem--your mod_python was built against a different version than your /bin/python executable.
You should really be using mod_wsgi. mod_python is deprecated and will not be supported much longer.
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