[aroma.affymetrix] Re: Regarding the copy number states and further processing

2015-01-20 Thread Sam Padmanabhuni
Hi Liu, That is good to know some one is doing similar stuff as mine. I was going to through 2-3 papers which described to get a comprehensive list of CNVs it is better to consider a CNV which is called in 2 or more CNV calling algorithms. This is what I have observed recently in some papers

[aroma.affymetrix] Re: Regarding the copy number states and further processing

2015-01-20 Thread Chengyu Liu
Hi Sam, I am doing similar stuff with you. I also need to identify regions which are amplified or deleted. I have paired samples. There are quite many different ways to define gain and loss of a segment. It is a tricky question. >From the literature search, it seems best to call CNVs using fr

[aroma.affymetrix] Re: Regarding the copy number states and further processing

2015-01-20 Thread Sam Padmanabhuni
Hi, Thanks for the clarification. I am working on finding segments of duplication/deletion that are only present in patients but not in controls. And my samples are non-paired. >From the literature search, it seems best to call CNVs using from different softwares to have a comprehensive list

[aroma.affymetrix] Re: Regarding the copy number states and further processing

2015-01-20 Thread Chengyu Liu
Hi, On Monday, January 19, 2015 at 3:42:59 PM UTC+2, Sam Padmanabhuni wrote: > > Dear AromaAffymetrix Team, > > First of all, thank you very much for such a detailed vignette on how to > perform the CNV analysis. > > I am Sam, a PhD student in genetics, working on CNV analysis on data from > Cy