Is there a way to incorporate tumor purity estimates (e.g. from ASCAT) into the Aroma pipeline for segmenting copy number changes between parent and tumor? We are looking at cell lines derived from tumors to compare consistency between copy number variations. The tumor purity in the parental cells has moderate variation, and the lines with lower purity in the parental are getting called to have more copy number changes than those with higher purity, even though a manual inspection suggests the differences are merely due to change in purity.
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