Ini saya copykan dari artikel kiriman mbak Dianjani
semoga berguna.

Mamanya Dafi

Sepsis 
Alternative names: gram-positive bacteremia;
gram-negative bacteremia 
                  
Definition: A serious infection caused by bacteria
that has entered a wound or body tissue that leads to
the formation of pus, or to the spread of the bacteria
in the blood 
                  
Causes, incidence, and risk factors: Sepsis is a
result of a bacterial infection that can originate
anywhere in the body. Common sites are the
genitourinary tract, the 
liver or biliary (liver secretion) tract, the
gastrointestinal tract, and the lungs. Less common
sites are intravenous lines, surgical wounds, surgical
drains, and sites of skin breakdown known as decubitus
ulcers or bedsores. The infection is usually confirmed

by a positive blood culture. The infection can lead to
shock, called septic shock. Low blood pressure and a
change in mental status may be early-warning signs of
shock. 
                  
There has recently been an increase in the occurance
of sepsis caused by organisms that are resistant to
most standard antibiotics. 
                  
Sepsis can be a life-threatening situation, especially
in people with a weakened immune systems. 
The risk factors associated with sepsis include: 
recent bacterial pneumonia meningitis 
a urinary tract infection that does not respond to
antibiotics 
osteomyelitis bacterial peritonitis 
a recent dental procedure 
a recent endoscopy procedure 
a recent cardiovascular procedure 
an indwelling urinary catheter 
a recent major surgery 
cellulitis 
a recent therapy with antibiotics 
People whose immune systems are suppressed by
therapies or by certain diseases are at higher risk
for sepsis. The incidence is 2 out of 10,000 people. 
                  
Prevention: 
Many cases are not preventable. Awareness of risk may
allow earlier detection. 
                  
Symptoms: 
fever 
body temperature may be normal or low 
hyperventilation 
chills 
shaking 
warm skin 
skin rash 
rapid heart beat (tachycardia) 
confusion or delirium 
decreased urine output 

Additional symptoms that may be associated with this
disease: 
red skin spots 
joint pain 
hallucinations 
hypotonia 
                  
Signs and tests: white blood cell count that is low or
high blood culture that is positive for bacteria blood
gases that reveal acidosis urine pH that may be low 

This disease may also alter the results of the
following tests: 
RBC indices 
peripheral smear 
fibrin degradation products 
cholesterol test 
blood differential 
                 
Treatment: 
Hospitalization is necessary to achieve treatment
goals. Intravenous antibiotic therapy should be
initiated as soon as the diagnosis is suspected. The
therapy is not delayed while determining the causative
organism. Sometimes more than one type of antibiotic
is 
given while results of the blood cultures are pending.
Antibiotics  can then be changed when the culture
results are available and the causative organism is
known. The source of the infection should be 
identified if possible, which may mean further
diagnostic testing. Sources such as infected
intravenous lines or surgical drains can be removed,
and sources such as abscesses can be surgically
drained. 
Supportive therapy with oxygen and intravenous fluid
and management of complications is important for a
good outcome. 
                  
Expectations (prognosis): 
The death rate can be as high as 60% for people with
severely low white blood cell counts or suppressed
immune systems. In people with no underlying disease,
the death rate is about 5%. 
                  
Complications: 
septic shock 
impaired blood flow to vital organs (brain, heart,
kidneys) 
disseminated intravascular coagulation 


--- Ninin Kristanti <[EMAIL PROTECTED]>
wrote:
> Mamanya Dafi, mau dong copy artikelnya, saya nyari2
> kok ngga ketemu ya.....?
> Thanks
> Regards,


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