Re: [Bioc-devel] Dependency on devtools in biocLite()

2017-01-18 Thread Martin Morgan
On 01/17/2017 07:15 AM, Andrzej Oleś wrote: Thanks Martin! I see your point - then I suggest that at least the call to `devtools::install` is guarded by a customized more informative error massage, something along the lines: Package 'devtools' missing: please install it (e.g., by a call to

Re: [Bioc-devel] Code quality and bug reports

2017-01-18 Thread Obenchain, Valerie
Hi, On 01/14/2017 03:01 AM, Lluís Revilla wrote: > Dear Valerie and all, > > If I understood the page you kindly linked correctly, a package is deprecated: > 1) When it fails to build and check (unless it is fixed). > 2) When the maintainer asks for it. > 3) If the maintainer is unresponsive (I

Re: [Bioc-devel] Alternative Hypothesis Specification For edgeR

2017-01-18 Thread Aaron Lun
Ah - sorry - upon re-reading your message, I realized I misunderstood your question. So basically you want to make your LRT p-value one-sided; I can see how that would be useful, e.g., when comparing to negative controls in ChIP-seq or other technologies. I've been doing it fairly simply,

Re: [Bioc-devel] Alternative Hypothesis Specification For edgeR

2017-01-18 Thread Aaron Lun
Hi Dario, I guess so - it would be a fairly easy extension of glmLRT - but why? I can't think of many situations where a non-zero log-fold change is expected under the null hypothesis. Mixture experiments, or correcting for gene dosage due to copy number variants, perhaps. Cheers, Aaron On