[Bioc-devel] biomaRt::getBM column names

2013-06-07 Thread Martin Morgan
Hi Steffen -- getBM now returns the 'description' rather than 'name' of biomaRt columns, e.g., mart <- useMart("ensembl") datasets <- listDatasets(mart) mart<-useDataset("hsapiens_gene_ensembl",mart) df <- getBM(attributes=c("affy_hg_u95av2", "hgnc_symbol",

Re: [Bioc-devel] Size limits of packages when including other executables

2013-06-07 Thread Dan Tenenbaum
On Thu, Jun 6, 2013 at 1:48 AM, Thomas Dybdal Pedersen wrote: > Hi > > I'm developing a wrapper for the peptide-identification tool MS GF+. The > algorithm is developed in Java and the .jar file has a size around 20 mb. > > For the ease of the user, I think it would make sense to pack the java co

Re: [Bioc-devel] Can I analyze with bioconductor a microarray experiement where the distribution of probes intesisties follow a bi modal distribution?

2013-06-07 Thread Vincent Carey
there was a package addressing cross-sample distributional shapes, edd, but it was retired due to lack of use, IIRC http://books.google.com/books?id=jIMO2rRaCbMC&pg=PA55&lpg=PA55&dq=edd+expression+density+diagnostics&source=bl&ots=tXKdRicJ8x&sig=vZF9tRCrLAhiaVinx7yeEMh3bSA&hl=en&sa=X&ei=DgOyUbitIt

Re: [Bioc-devel] Can I analyze with bioconductor a microarray experiement where the distribution of probes intesisties follow a bi modal distribution?

2013-06-07 Thread Miguel Moreno-Risueno
Hi James Thank you very much for the answer. Yes I understand that it is across experiments that a given probe should follow a normal distribution, but if this is true shouldn't the population of those probes similarly follow a normal distribution in turn, or not necessarily. I am concern that bec

Re: [Bioc-devel] Can I analyze with bioconductor a microarray experiement where the distribution of probes intesisties follow a bi modal distribution?

2013-06-07 Thread James W. MacDonald
Hi Miguel, On 6/7/2013 5:11 AM, Miguel Moreno-Risueno wrote: Hello all, We have recently received a microarray experiment in the Nimblegen platform where the intensity of the probe sets follow a bi-modal distribution. We have been said from the facility that this is because of the dynamic r

[Bioc-devel] Can I analyze with bioconductor a microarray experiement where the distribution of probes intesisties follow a bi modal distribution?

2013-06-07 Thread Miguel Moreno-Risueno
Hello all, We have recently received a microarray experiment in the Nimblegen platform where the intensity of the probe sets follow a bi-modal distribution. We have been said from the facility that this is because of the dynamic range of the Agilent scanner they use. We are concerned about t