Dear Caret users:
I have a group of MRIs of children with unilateral brain injury that I
would like to get morphometric measurements on. Specifically, I would
like to know how the gray and white matter in each hemisphere compare
overall (for the whole hemisphere) and how they compare for specific
regions (especially the traditional language areas and the white matter
tracts feeding these areas).
Can Caret give me estimates of the amount of gray and white matter in
each hemisphere (and/or for each region) with patients that have brain
lesions?
Would it be feasible to get this data whether the patient has
periventricular lesions (that don't affect the cortex) as well as
patients where the lesions do affect the cortical surface?
Finally, if I were to draw the lesioned area (as I have already done in
AFNI, for example), would Caret be able to normalize the brains around
the lesion (according to an atlas or averaged brain)? Or do you have
your own way of handling lesioned brains?
I have had a terrible time finding a method to analyze the structural
MRI information in these brain-lesioned brains, so I would appreciate
your input on this issue.
Many thanks,
Joan Fisher
University of Chicago
