[ccp4bb] Crystallography Associate Position at Novartis

2014-08-01 Thread Sprague, Elizabeth
We have an opening for a Crystallography Research Associate position in the Structural Biophysics Group at Novartis (Cambridge, MA). The candidate must have a good foundation in protein expression purification, and then crystallography and/or biophysics experience is desirable, but not

[ccp4bb] Disorder in crystal packing

2014-08-01 Thread Paul Paukstelis
Greetings, Currently working on a DNA quadruplex structure in which 4 of the 10 residues are partially disordered. 1.50 A resolution, and currently refined to R/Rfree of 12/14%. Apparent spacegroup is P4, two molecules in AU, both of which reside on the 4-fold to generate quadruplexes.

[ccp4bb] Crystallization of aggregation prone protein

2014-08-01 Thread Debasish Kumar Ghosh
Dear All, I am working with a protein which is having an N-terminal unstructured region (approximate of length 40-60 amino acids) and C-terminal region which is having structured (possibly alpha helical region as probed by CD spectroscopy, Bioinformatic studies) property. The protein, in