If the following is not deleterious to your protein and its function you
could introduce mutations that prevent dimerization.
~Jeff
I have a similar case, where in there are multiple binding sites on the
protein for the ligand and ligand induces dimerization.So it is not
helpful
even if I
Experts,
I would like to compare the substrate binding site of two homologous
proteins. Based on crystal structures it is clear that the substrate
binding site of protein A is more solvent exposed then protein B.
Is there a way to measure the solvent exposure of the substrate in protein
A and B?
As I recall autodock vina is not set up to dock two ligands at once. That
might be a better question to ask the autodock listserve.
Regardless, I would recommend docking one compound at a time to generate a
reasonable amount of docking poses.
From the first round of docking you could then treat
