Dear all - please *help us help you*:
* Some of you have used and even liked Diamond's XChem facility for
crystal-based fragments screening.
* Some of you have wanted to use it but didn't know how or didn't get
time.
* Lots and lots of you hope your crystallography will turn into
chemical biology and drug discovery.
If you're one of those: *s*how your support for a lighting-fast XChem
beamline in Diamond-II:
1. Dial in to the webinar next Monday 4pm (/details below/)
2. Sign up to the Interest Group (/here
<https://diamond.us20.list-manage.com/track/click?u=3de94671e0e91f373e1995d94&id=73866c46cb&e=b2cea28e06>//or
linked below/)
3. Drop us statements of support (in this form
<https://forms.office.com/Pages/ResponsePage.aspx?id=dLonnQABDU2B_x1yja6N9sORn9fQKRxBrdwp3-jvXxFURTZRTU9VM1I2VVZEVEVFS1hJTlNHUThISi4u%C2%A0>
or linked from here
<https://www.diamond.ac.uk/Home/About/Vision/Diamond-II/Flagship-Beamline-Projects.html#>)
4. Retweet this
<https://twitter.com/FrankvonDelft/status/1326531394307158018>
Diamond-II is planning to upgrade and reinvent, by mid-2027; this
includes new and upgraded beamlines - and rebuilding I04-1 as K04. It
should increase XChem throughput up to 15x, which means far bigger XChem
fragment screens for far more of your projects, and (we conclude) far
more of your chemical biology and drug discovery, much accelerated (e.g.
this <https://www.biorxiv.org/content/10.1101/2020.10.29.339317v1?rss=1>).
We're about to submit the science case - and we're seeking as many
statements of support as possible.
Please spread the word: circulate to all your colleagues in chemistry
and drug design and chemical biology - in fact, this touches so many
discplines, you can probably send to just about everybody you work with...
Thank you for your help!
Frank
Prof Frank von Delft
Professor for Structural Chemical Biology
Principal Beamline Scientist: I04-1/XChem
Diamond Light Source
Principal Investigator: Protein Crystallography
Centre for Medicines Discovery
Oxford University
-------- Forwarded Message --------
Subject: Diamond-II Webinar: K04 Beamline Rebuild for Ultra-XChem
Date: Mon, 9 Nov 2020 09:54:39 +0000
From: Diamond Communications <diamond.communicati...@diamond.ac.uk>
Reply-To: Diamond Communications <diamond.communicati...@diamond.ac.uk>
To: frank.von-de...@diamond.ac.uk
Diamond-II Webinar: K04 Beamline Rebuild for Ultra-XChem
*Monday 16th November 2020, 16:00-17:00
Click here to visit the event page
<https://diamond.us20.list-manage.com/track/click?u=3de94671e0e91f373e1995d94&id=1134639c78&e=b2cea28e06>*
Dear Colleagues,
Structural and chemical biologists and medicinal chemists are warmly
invited to this webinar, which will describe the rebuilding of beamline
I04-1 as K04 for Diamond-II. The project will achieve ultra-high
throughput XChem fragment screening and thereby help drive routine and
rapid pre-clinical impact in structure-based drug discovery and chemical
biology. Diamond-II
<https://diamond.us20.list-manage.com/track/click?u=3de94671e0e91f373e1995d94&id=99d1909760&e=b2cea28e06>is
a coordinated programme of development that includes a major upgrade of
the storage ring to deliver low emittance at higher energy, along with a
range of rebuilt and enhanced beamlines. The K04/XChem project is part
of a transformational change for the MX and XChem communities, and
attendance and feedback are highly encouraged.
*Proposal background*
The K04/XChem flagship builds on the success and oversubscription of the
XChem fragment screening facility
<https://diamond.us20.list-manage.com/track/click?u=3de94671e0e91f373e1995d94&id=2204b7381d&e=b2cea28e06>,
developed in tandem with the evolution of beamline I04-1. The facility
provides a world-unique offering for structure-based drug design, and is
in heavy academic and industrial demand, with the resilience to support
significant COVID
<https://diamond.us20.list-manage.com/track/click?u=3de94671e0e91f373e1995d94&id=de1fafe6c2&e=b2cea28e06>work
<https://diamond.us20.list-manage.com/track/click?u=3de94671e0e91f373e1995d94&id=28fc8c1744&e=b2cea28e06> during
lockdown.
The Diamond-II machine configuration necessitates removing beamline
I04-1, providing the opportunity to rebuild it on the new K04 straight,
delivering a beamline of vastly increased flux and brilliance, along
with extreme automation. The resulting order-of-magnitude increase in
throughput will fundamentally shift the scientific scope of
crystallographic fragment screening. On the one hand, a far larger range
of classes of drug targets will become viable, even when diffraction is
weak. On the other hand, routinely large experiments will help achieve
the coming revolution in rational drug discovery, by allowing all key
interactions and conformations to be observed in 3D up front, providing
the raw data that future algorithms will be able to exploit to design
clinic-ready drug candidates from scratch
*User community input & webinar*
In order to provide you with more detail about the K04 beamline rebuild
and its future Ultra-XChem capabilities, we have organised a webinar on
*Monday 16th November 2020, 16:00-17:00 (GMT) *and encourage you to
attend and to save the date in your calendar, along with the link and
passcode to join:
*Link to join:
**_https://diamondlight.zoom.us/j/99099960845?pwd=dUNiY2gxK3YzWStoYkcyTERXYlI0UT09
<https://diamond.us20.list-manage.com/track/click?u=3de94671e0e91f373e1995d94&id=a6c152451c&e=b2cea28e06>_
Passcode: *902594
For more details, visit the event page here
<https://diamond.us20.list-manage.com/track/click?u=3de94671e0e91f373e1995d94&id=5759aa3e1b&e=b2cea28e06>.
In addition, if you are interested in keeping up to date on the
K04/XChem User Working Group progress and would like to receive updates
by email, please sign up to our *K04/XChem Flagship Interest Group* *by
filling out this short form*
<https://diamond.us20.list-manage.com/track/click?u=3de94671e0e91f373e1995d94&id=73866c46cb&e=b2cea28e06>.
We look forward to your participation and hearing your feedback on this
exciting initiative.
Best wishes,
Diamond-II K04/XChem User Working Group
Diamond Light Source Logo
<https://diamond.us20.list-manage.com/track/click?u=3de94671e0e91f373e1995d94&id=6b6f0c2dee&e=b2cea28e06>
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