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Date: Mon, 10 Aug 2009 11:10:42 +0800
From: wdh0...@gmail.com
Subject: Re: [ccp4bb] How to model apo protein structure from solved ligand
bound high resolution structure?
To: CCP4BB@JISCMAIL.AC.UK
More information about
Dear CCP4ers,
Recently we have solved two structures from E.coli in high resolution, which
have bound two different ligands tightly already. Here I want to know if
there is any program which can let us model the structure of our apo
proteins confidently. Thanks ahead for any comment and input.
More information about the two ligand bound structures, each protein is
composed of two globular domains, between the two globular domains, there
lies a deep cleft and ligand sits or buried there comfortably. These two
domains are connected by a hinge region, here we want to model how this
hinge
