Dear All, We want to wish you welcome to the 1st Workshop from LINXS Membrane Protein Working Group taking place digitally on Zoom. The Membrane Protein Working Group is dedicated to explore the unique challenges involved in research on the structural biology of membrane proteins. Our first, "*Structural Resolution of Membrane Proteins: From Expression to Sample Preparation*'' workshop will focus specifically on three areas: expression systems, sample preparation and quality control.
*Where:* Online, a zoom link will be provided just before the event *When:* May 25-26 (noon-to-noon) CET *Abstract submission deadline:* 5th of May, 2021 *Registration deadline:* 20th May 2021 AIM The aim is to provide expert overview about different platforms for recombinant protein productions and purification strategies for crystallography techniques. Overcoming low yield expression, misfolded proteins and difficulties in purifying stable functional proteins are among the most common bottlenecks delaying structural characterization. We invite scientists to introduce their best practices in these subjects in order to provide greater knowledge and knowledge transfer on how best to deal with these challenges. CONTRIBUTED TALKS We hope to engage the attendance from PhD students and postdocs from a range of disciplines, as well as more senior researchers. We are encouraging participants, and especially PhD students, to consider presenting their research in a contributed talk (call for abstracts) and also to promote lively discussions. CONTENT *Day 1:* - Workshop aims and scope of the general problem - Membrane Protein Expression - Comparison of different expression systems - Success stories vs trouble-shooting problem areas, trial and error - Confirmed speakers: *Roslyn Bill* (Aston University) - *Recombinant membrane protein production in microbial hosts* *David Drew* (Stockholm University) - TBA *Joseph Lyons *(Aarhus University) - TBA *Day 2:* - Sample Preparation, Quality Control - Membrane solubilization and other preparation methods Confirmed speakers: *Arjan Snijder* (AstraZeneca) - *Membrane protein purification and application in drug discovery* *Christopher G. Tate* (Cambridge University) - *Whipping GPCRs into shape for structure determination* In the autumn the plan is to continue further on topics about membrane protein crystallization techniques, Cryo-EM or neutron structures, scattering techniques and well-diffracting crystals. Please find *Registration* and Timetable (will be updated with abstracts) here: https://indico.linxs.lu.se/event/219/ The LINX organising Team. Regards, Swati Aggarwal Early Stage Researcher European Spallation Source Lund, Sweden email: swati.aggar...@ess.eu ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
