Applications are invited for a postdoctoral researcher position in the laboratory of Dr Paul Miller at the Department of Pharmacology, University of Cambridge, beginning from January – April 2023.
The project will study small molecule and/or antibody modulators of ion channels as research tools and therapeutic leads, in order to study channel subtype contributions to CNS physiology and disease and empower drug discovery. This is a great opportunity to gain experience in one or more aspects of handling challenging membrane proteins, understanding small molecule and/or antibody modulation, and cryo-EM, ideal for follow-on academic and biotechnology careers. The lab utilises mammalian cell protein expression systems, membrane protein purification, and cryo-EM via Arctica and Krios microscopes with K2/K3 direct detectors, and also has manual and automated electrophysiology equipment,. More information about the laboratory is available at https://www.phar.cam.ac.uk/research/miller. The applicant will be about to obtain a PhD or have obtained a PhD within the last 5 years. Experience in molecular biology, protein production, purification and structural biology (X-ray crystallography or cryo-EM) is required. You must be a careful and methodical worker, paying attention to accuracy, be able to take responsibility and interact as part of a tightly knit team, and be willing to work in a collaborative environment. You should be self-motivated and able to organise, perform and analyse experiments with minimal instruction. A recent relevant publication from the lab is: Kasaragod VB, Mortensen M, Hardwick SW, Wahid AA, Dorovykh V, Chirgadze DY, Smart TG, Miller PS. Mechanisms of inhibition and activation of extrasynaptic alpha-beta GABA-A receptors. Nature. 2022 Feb;602(7897):529-533. PMID: 35140402 Application Closing date: 30th November 2022 Project start date: January-April 2023 For more details and to apply: https://www.jobs.cam.ac.uk/job/37880/ Informal enquiries about the position can be made to Dr Paul Miller (pm...@cam.ac.uk<mailto:pm...@cam.ac.uk>) For enquiries about the online application process please contact Debbie Stanley, phar...@lists.cam.ac.uk Paul Miller, PhD University Lecturer in Pharmacology Department of Pharmacology University of Cambridge Tennis Court Road Cambridge CB2 1PD +44 1223 761267 https://www.phar.cam.ac.uk/research/miller ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
