Post for a colleague: We are seeking a highly trained and self-motivated postdoctoral associate/biomedical scientist (PhD or other doctoral degrees) to participate in chemogenomics-based drug research projects ( http://www.cbligand.org/XieLab). To advance our *CELL*-published technology of 3D Cryo-EM Structure of Human Cannabinoid Receptor CB2-Gi Signaling Complex *(*PMID:32004460), we are seeking an individual with the following expertise and qualifications:
- must have the expertise and working experience in molecular biology/microbiology (e.g., cloning, site-directed mutagenesis, CRISPR-Cas9, etc.) - working experience in autophagy, cell fate decision-making, and cell signaling studies that can be applied to targeting cannabinoid CB2 receptor, squestosome-1/p62, Ink4c/p18 proteins for drug research projects focusing on the following diseases: immune/inflammatory diseases (e.g., GVHD, IBD), acute myeloid leukemia (AML), multiple myeloma (MM), kidney fibrosis, Alzheimer’s diseases, hematopoietic stem cells, COVID-19, and osteoporosis; - experience working with cells at BSL2/BSL2+ is essential; experience with receptor binding affinity bioassay and cellular functional bioassays is desirable; - experience with *Baculovirus *(sf9) and/or *E coli *expression systems, IMAC, SEC, and other novel purification protocols; as well as AKTA purification and LC-MS/MS systems to provide functional proteins for bioassays and structural characterizations; experience with X-ray crystallographic biophysics and/or CryoEM is a plus; - must have demonstrated independent ability to design and execute experiments, prepare figures of results, analyze & interpret those results, and present them in a professional scientific manner; - must have experience in performing literature searches and can assist with scientific writing (manuscripts and grant proposals); meticulous record-keeping of research work is required; - good verbal and interpersonal skills are also necessary; individuals may be required to assist and guide graduate students and other post-docs in the lab. Salary is commensurate with experience. Please apply through the University of Pittsburgh Talent Center at www.join.pitt.edu. Also, please email your CV, letter, and three references to Prof. Sean Xie, sean....@pitt.edu, and his assistant Dr. Terry McGuire t...@pitt.edu with *“Manager-Postdoc*” in the subject line. The University of Pittsburgh is an Affirmative Action/ Equal Opportunity Employer and values equality of opportunity, human dignity, and diversity, EOE, including disability/vets. -- --------------------- Cheng Zhang ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
