A 2-years funded postdoctoral research position is immediately available at the newly established Structural Biology Group, at the Unit of Biophysics (UB), University of the Basque Country (UPV/EHU), Spain. We are seeking a highly motivated individual, interested to investigate the structural, mechanistic and functional properties of enzymes involved in bacterial pathogenesis. To this end, we are using a multidisciplinary approach including cellular and molecular biology, protein biochemistry, protein biophysics and structural biology. This position will provide excellent training opportunities and networked environment.
The UB is a joint center of the UPV/EHU and the Spanish Science Research Council, “Consejo Superior de Investigaciones Científicas” (CSIC). The center is located in the main campus of the UPV/EHU at Leioa, and is within 15 min driving distance from Bilbao. The UB is equipped with state-of-the-art facilities to conduct cutting-edge X-ray protein crystallography and membrane/protein biophysics. Candidates must hold a Ph.D. in biochemistry, molecular biology, biophysics, structural biology or related fields, with a strong background in molecular biology, biochemistry, and protein expression. Expertise in X-ray protein crystallography or other techniques in structural biology would be a plus. The candidate should have a strong publication record in quality peer-reviewed journals, demonstrated creative thinking, be able to work independently and have the ability to work collaboratively in a laboratory environment. The position will be open until filled. Applicants should send a cover letter, CV, and names/contact information of 2 references to: David Albesa-Jove IKERBASQUE Research Fellow Unit of Biophysics (UPV/EHU-CSIC) Barrio Sarriena S/N, 48940, Leioa, Bizkaia, SPAIN. E-mail: *davidalb...@gmail.com <davidalb...@gmail.com>* Websites: http://www.ikerbasque.net/index.php?option=com_researcher&task=view&rese=199&Itemid=302&lang=en_EN *https://sites.google.com/site/guerinlab/home <https://sites.google.com/site/guerinlab/home>* Recent Bibliography: - *Secondary structure reshuffling modulates glycosyltransferase function at the membrane.* D. Giganti, D. Albesa-Jové, S. Urresti, A. Rodrigo-Unzueta, M.A Martínez, N. Comino, N. Barilone, M. Bellinzoni, A. Chenal, M.E Guerin and P.M Alzari. *Nat Chem Biol. 11, 16-18 (2015).* - *Structural basis of chitin oligosaccharide deacetylation.* E. Andrés, D. Albesa-Jové, X. Biarnés, B.M. Moerschbacher, M. E. Guerin and A. Planas. *Angew Chem Int Ed Engl. 53, 1-6 (2014).* - *Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.* D. Albesa-Jové, L.R. Chiarelli, V. Makarov, M.R. Pasca, S. Urresti, G. Mori, E. Salina, A. Vocat, N. Comino, E. Mohorko, S. Ryabova, B. Pfieiffer, A.L. Lopes Ribeiro, A. Rodrigo-Unzueta, M. Tersa, G. Zanoni, S. Buroni, K.H. Altmann, R.C. Hartkoorn, R. Glockshuber, S.T. Cole, G. Riccardi and M.E. Guerin. *ACS Chem Biol. 9, 1567-1575 (2014).* - *Structure-function relationships of membrane-associated GT-B glycosyltransferases.* D. Albesa-Jové, D. Giganti, M. Jackson, P.M. Alzari PM, and M.E. Guerin. *Glycobiology, 24, 108-124 (2014).* - *Conformational plasticity of the essential membrane-associated mannosyltransferase PimA from mycobacteria.* D.O. Giganti, J. Alegre-Cebollada, S. Urresti, D. Albesa-Jové, A. Rodrigo-Unzueta, N. Comino, M. Kachala, S. López-Fernández, D.I. Svergun, J.M. Fernández and M.E. Guerin. *J Biol Chem. 288, 29797-29808 (2013).* - *Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria.* S. Urresti, D. Albesa-Jové, F. Schaeffer, H.T. Pham, D. Kaur, P. Gest, M.J. van der Woerd, A. Carreras-Gonzalez, S. Lopez-Fernandez, P.M. Alzari, P.J. Brennan, M. Jackson and M. E. Guerin. *J Biol. Chem. 287, 24649-24661 (2012).*
