The lab of Dr. Taosheng Chen is recruiting a Structural Biologist to join the efforts in structural determination of protein-ligand complexes and contribute structural biology insights into the mechanism of action of novel chemical probes. The Chen Laboratory (https://www.stjude.org/chen) uses multidisciplinary approaches to study transcriptional regulation by nuclear receptors, including chemical biology approaches to develop chemical modulators, with a goal to understand nuclear receptor-regulated transcription networks and design therapeutic approaches to overcome drug resistance and tumorigenesis in cellular and animal models. The structural biology efforts are expected to synergize with our chemical biology efforts and enable completion of impactful projects (*Nat Commun* 8:741, 2017; *J Am Chem Soc**2021, DOI: 10.1021/jacs.1c07066*). The Chen Laboratory provides a unique research environment: in addition to basic research, lab members will learn and gain experience in small molecule drug discovery from target validation, chemical probe discovery and optimization to preclinical mechanistic studies. The *Senior or Lead Researcher* will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists, and technologists.
The successful candidate will have proved experience in expression construct design, molecular cloning, protein expression and purification, optimization of crystallization conditions, crystallization and structural determination of protein-ligand complexes using X-ray crystallography. Experience in the following areas is a plus: purification and crystallization of nuclear receptors; synchrotron data collection; biophysical assays; *in silico* modeling of protein-ligand interactions; preparation of manuscripts; along with a strong publication record. Please direct your inquiries and current CV to Dr. Taosheng Chen ( taosheng.c...@stjude.org) or *apply online* ( https://careers-stjude.icims.com/jobs/8708/sr-researcher/job?hub=15&mobile=false&width=1180&height=500&bga=true&needsRedirect=false&jan1offset=-360&jun1offset=-300 ). *Minimum Education* Bachelor's or Master's degree in biology, chemistry, or a related field required. PhD in structural biology is essential, and relevant postdoctoral training is preferred. *Contact* Taosheng Chen, PhD Member (Professor), Department of Chemical Biology and Therapeutics Director, High Throughput Bioscience Center St. Jude Children's Research Hospital 262 Danny Thomas Place Memphis, TN 38105-2794 USA Phone: 1-901-595-5937 Fax: 1-901-595-5715 Email: taosheng.c...@stjude.org Website: https://www.stjude.org/chen ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
