[ccp4bb] llg is negative in phaser

Hi all, does anyone solve their structure by molecular replacement with phaser with LLG 0? Thanks lisa

Re: [ccp4bb] llg is negative in phaser

Dear Lisa, It is actually reasonably common that a clear solution (large TFZ) is found in Phaser with a negative LLG. The negative LLG tells you that the model doesn't agree with the data as well as one would expect, given what you have told Phaser about the completeness of the model and its

Re: [ccp4bb] llg is negative in phaser

On Tue, 2012-06-19 at 16:43 +0800, LISA wrote: Hi all, does anyone solve their structure by molecular replacement with phaser with LLG 0? Thanks lisa AFAIU, this means that your estimate of the solvent content is too low. If you increase that, eventually you should get positive LLG.